Results 121 to 130 of about 1,366,098 (338)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Helping behaviour of volunteers in providing post-disaster psychosocial assistance

Jàmbá
This study explores the ways that volunteers help in overcoming the negative impacts of disasters. The direction of this research is the production of guiding data for roadmaps for strengthening the capacity of volunteers as the spearhead of disaster ...
Nevi K. Arianti, Muhammad Baiquni, Koentjoro Soeparno, Arifin Nur A. I.   +3 more
doaj   +1 more source

Influence of committed volunteers on helping behavior in emergency evacuations [PDF]

, 2022
Jaeyoung Kwak, Michael Lees, Wentong Cai, Ahmad Reza Pourghaderi, Marcus Eng Hock Ong   +4 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Social prediction errors in assisting strangers: the role of outcomes and contexts

Frontiers in Psychology
IntroductionHelping behavior is a fundamental aspect of social interaction, yet little is known about how accurately helpers can predict the emotional responses of help-seekers, particularly when interacting with strangers.MethodsThis study investigated ...
Yan Li, Zhiwei Liu
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The ironic effect of entitlement: Giving behavior increases with entitled pursuit of information

Judgment and Decision Making
Willingness to help a needy person may depend on whether the person is perceived as responsible for their predicament. However, information regarding the cause is not always available, and people often ‘look the other way’ when it is.
Ilana Ritov, Stephen M. Garcia
doaj   +1 more source

Dual effects of implicit bystanders: Inhibiting vs. facilitating helping behavior [PDF]

, 2009
Stephen M. Garcia, Kimberlee Weaver, John M. Darley, Bryan T. Spence   +3 more
openalex   +1 more source