Results 81 to 90 of about 122,442 (282)

Behavioural approaches are helpful in overactive bladder

open access: yesBMJ, 2003
EDITOR—Herbison et al made a plea for a more pragmatic approach to evaluating patients with an overactive bladder syndrome.1 A strong criticism of the work performed to date relates to the use of placebo as a control. They argue for the use of a behavioural …
Christian Brown, Tim Lane, Mark Emberton
openaire   +2 more sources

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

open access: yesFEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga   +6 more
wiley   +1 more source

Domain Modelling in Computational Persuasion for Behaviour Change in Healthcare [PDF]

open access: yesarXiv, 2018
The aim of behaviour change is to help people to change aspects of their behaviour for the better (e.g., to decrease calorie intake, to drink in moderation, to take more exercise, to complete a course of antibiotics once started, etc.). In current persuasion technology for behaviour change, the emphasis is on helping people to explore their issues (e.g.
arxiv  

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

open access: yesFEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva   +1 more
wiley   +1 more source

Offering mental health first aid to a person after a potentially traumatic event: a Delphi study to redevelop the 2008 guidelines

open access: yesBMC Psychology, 2020
Background Trauma has a major impact on the mental health and wellbeing of people globally. Friends, family and members of the public are often well positioned to provide initial assistance if someone is experiencing extreme distress following a ...
Kathryn J. Chalmers   +6 more
doaj   +1 more source

Learning Purposeful Behaviour in the Absence of Rewards [PDF]

open access: yesarXiv, 2016
Artificial intelligence is commonly defined as the ability to achieve goals in the world. In the reinforcement learning framework, goals are encoded as reward functions that guide agent behaviour, and the sum of observed rewards provide a notion of progress.
arxiv  

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

open access: yesFEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze   +3 more
wiley   +1 more source

Modelling Bushfire Evacuation Behaviours [PDF]

open access: yesarXiv, 2019
Bushfires pose a significant threat to Australia's regional areas. To minimise risk and increase resilience, communities need robust evacuation strategies that account for people's likely behaviour both before and during a bushfire. Agent-based modelling (ABM) offers a practical way to simulate a range of bushfire evacuation scenarios. However, the ABM
arxiv  

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Fermion and Boson Pairs in Beamsplitters and MZIs [PDF]

open access: yesJ. Phys. Photonics 7 012001 (2025)
In this short Topical Review, we look at something typically considered trivial, but not given formally elsewhere -- the behaviour of first multiple fermions, then multiple bosons, at a beamsplitter. Extending from this, we then describe the behaviour of multiple fermions and multiple bosons in Mach-Zehnder interferometers (MZIs).
arxiv   +1 more source

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