Results 51 to 60 of about 11,664 (246)

C1q deletion exacerbates stress-induced learned helplessness behavior and induces neuroinflammation in mice

Translational Psychiatry, 2022
Increased levels of pro-inflammatory cytokines have been reported in postmortem brain samples and in the blood of depressed subjects. However, the inflammatory pathways that lead to depressive-like symptoms are not well understood.
Amit Kumar Madeshiya, Carl Whitehead, Ashutosh Tripathi, Anilkumar Pillai   +3 more
doaj   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Study on the characteristics and influencing factors of learned helplessness in breast cancer patients undergoing chemotherapy: A latent class analysis

Acta Psychologica
Objective: This study employed a latent profile analysis (LPA) to identify distinct subgroups of learned helplessness among Chinese breast cancer chemotherapy patients and examined influencing factors.
Xiaoxiao Li, Yanyan Jiao, Zhongqiang Guo, Yifan Lu, Yanjun Huang, Xiaofang Shen, Chaoran Chen   +6 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

The effect of students' effort–reward imbalance on learning engagement: the mediating role of learned helplessness and the moderating role of social support

Frontiers in Psychology
IntroductionTo explore the predictive effect of effort–reward imbalance on students' learning engagement and to elucidate the underlying mechanism, 796 students were selected for a survey.MethodsThe participants were required to complete four scales: the
Shengmin Liu, Yuanru Wang, Wanning He, Yu Chen, Qiangqiang Wang   +4 more
doaj   +1 more source

Learned Helplessness in Renal Dialysis Patients: Concept Analysis with an Evolutionary Approach

Patient Preference and Adherence, 2022
Chunyan Xie,1,2 Li Li,1– 3 Yamin Li1 1Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China; 2XiangYa Nursing School, Central South University, Changsha,
Xie C, Li L, Li Y
doaj  

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

MENGATASI LEARNED HELPLESSNESS PADA SISWA TINGGAL KELAS MELALUI KONSELING RASIONAL EMOTIF TEKNIK HOMEWORK ASSIGNMENTS

Indonesian Journal of Guidance and Counseling: Theory and Application, 2012
This study aims to determine the efforts and success in overcoming learned helplessness behavior in students failing grades through rational emotive counseling techniques homework assignments. Type of study used is action research.
Riski Aulia
doaj  

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source