Results 51 to 60 of about 11,702 (244)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Learned Helplessness and Perceived Social Support among Patients with Mental Illness: A Cross-sectional Study [PDF]

Indian Journal of Private Psychiatry
Background: Mental illnesses often have a long term, chronic or recurring course. This is usually associated with repeated remissions and relapses. Such persons experience several setbacks in life in the areas of family relationships, job, participation ...
Shinu Joseph, Saleem TK, Vipin Revathi, Harish M Tharayil   +3 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Comparison of the effectiveness of cognitive-behavioral therapy with behavioral activation therapy on learned helplessness and cognitive emotion regulation in individuals with depressive symptoms

Fiyz̤, 2022
Background: Depression is one of the most important psychological problems in society that reduces their health. This study aimed to compare the effectiveness of cognitive-behavioral therapy with behavioral activation therapy on learned helplessness and ...
Kiaeian-Mousavi F, Mafakheri A, Mohammadzade-Ebrahimi A   +2 more
doaj  

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Effectiveness of psychological empowerment training program based on individual psychology Adler's theory on female-headed household’s learned helplessness [PDF]

Faṣlnāmah-i Farhang Mushavirah va Ravān/Darmānī, 2017
Purpose: The objective of this study was to determine the effectiveness of psychological empowerment training program based on individual psychology Adler's theory on female-headed household’s learned helplessness.
Alireza karimivakil, Abdollah Shafiabadi, kiiumars farahbakhsh, jalil younesi   +3 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Study on the characteristics and influencing factors of learned helplessness in breast cancer patients undergoing chemotherapy: A latent class analysis

Acta Psychologica
Objective: This study employed a latent profile analysis (LPA) to identify distinct subgroups of learned helplessness among Chinese breast cancer chemotherapy patients and examined influencing factors.
Xiaoxiao Li, Yanyan Jiao, Zhongqiang Guo, Yifan Lu, Yanjun Huang, Xiaofang Shen, Chaoran Chen   +6 more
doaj   +1 more source