Results 31 to 40 of about 35,562 (194)
Advanced Science, EarlyView.This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding +13 more
wiley +1 more source
Applied SciencesBlood typing remains a manual, subjective procedure when not reliant on centralized laboratory infrastructure. This study presents an automated blood typing system for point-of-care deployment, developed in collaboration with CRIAM, whose portable device
Bruno Silva +4 more
doaj +1 more source
Foods, 2021 Lectins are ubiquitous proteins characterized through their ability to bind different types of carbohydrates. It is well known that active lectins from insufficiently prepared legumes can cause adverse human health effects.
Anežka Adamcová +2 more
doaj +1 more source
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Analysis of the sensitization activity of Moringa oleifera leaves protein
Frontiers in NutritionThe determination of allergenic proteins in Moringa oleifera leaves, which is the main components of immune activity, has enabled the development of a more effective method for evaluating the activity of extracted Moringa oleifera leaves protein. In this
Juan Lu +11 more
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Molecules, 2022 The Moroccan flora abounds and is an important reserve of medicinal plants. Nigella sativa and Lepidium sativum are plants that are widely used in traditional medicine for their multiple therapeutic properties.
Hafssa Ouattar +10 more
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Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source
A SPECTRUM OF CARBOHYDRATE SPECIFICITY OF RECEPTORS OF ADHESION OF VIBRIO CHOLERAE NON-O1, NON-O139
Медицинский вестник Юга России, 2013 Purpose: revealing of the fullest spectrum of specificity lectin receptors strains of Vibrio cholerae non-O1, non-O139, participating in adgesion mechanisms, on model of agglutination of erythrocytes in reaction of competitive ingibition.Materials and ...
N. R. Telesmanich +3 more
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Human Vaccines & Immunotherapeutics, 2022 Efficacy and safety data on quadrivalent influenza vaccines (QIVs) for immunization of Indian children are scarce. This phase 3, registration study evaluated the immunogenicity, safety, and tolerability of a QIV in Indian children aged 6–35 months (Group
Nijalingappa K. Kalappanavar +11 more
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Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy
Advanced Science, EarlyView.A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan +9 more
wiley +1 more source