Results 101 to 110 of about 149 (149)

Allergic Reactivity and Memory Occur Independently of Sequential Switching Through IgG1

Allergy, EarlyView.
Sequential switching through IgG1 is not required to produce IgE with sufficient allergen‐binding affinity to cause anaphylaxis against food allergens. Sequential switching through IgG1 does not confer a competitive advantage to become an IgE‐expressing cell.
Joshua F. E. Koenig, Adam K. Wade‐Vallance, Rodrigo Jiménez‐Saiz, Kelly Bruton, Siyon Gadkar, Emily Grydziuszko, Tina D. Walker, Melissa E. Gordon, Amy E. Gillgrass, Justin J. Taylor, Susan Waserman, Manel Jordana   +11 more
wiley   +1 more source

Cardiac function and coronary plaque development following masculinizing gender‐affirming hormone therapy: A prospective cohort study

Andrology, EarlyView.
Abstract Introduction Myocardial dysfunction and the presence of calcified and non‐calcified coronary plaques are predictors of cardiovascular disease. Masculinizing gender‐affirming hormone therapy may increase cardiovascular risk, highlighting the need for prospective studies to evaluate cardiovascular outcomes during gender‐affirming hormone therapy.
Laust Frisenberg Buhl, Marianne S. Andersen, Jan Frystyk, Axel Diederichsen, Selma Hasific, Rikke Hjortebjerg, Jordi Sanchez Dahl, Manijeh Noori, Kirstine Nørregaard Hansen, Gitte Maria Jørgensen, Camilla Viola Palm, Tine Taulbjerg Kristensen, Dorte Glintborg, Louise Lehmann Christensen   +13 more
wiley   +1 more source

Cardiovascular safety of testosterone therapy—Insights from the TRAVERSE trial and beyond: A position statement of the European Expert Panel for Testosterone Research

Andrology, EarlyView.
Abstract Introduction Testosterone therapy has become a cornerstone treatment for men with hypogonadism, offering significant benefits such as improved sexual function, mood, muscle mass, and bone density. However, concerns about its cardiovascular safety have historically tempered its use.
Michael Zitzmann, Giulia Rastrelli, Robert D Murray, David Edwards, Yacov Reisman, Preethi Mohan Rao, Alexander Sahi, Thomas Hugh Jones, Alberto Ferlin, Eleni Armeni, Emiliano Corpas, Jann‐Frederik Cremers, Janine David, Stefan Arver, Leen Antonio, Giovanni Corona   +15 more
wiley   +1 more source

Safety of enoxaparin in patients implanted with continuous flow left ventricular assist devices

Artificial Organs, Volume 49, Issue 4, Page 639-648, April 2025.
There was no significant difference in major bleeding or thromboembolic events between patients who received enoxaparin 1 mg/kg every 12 h (LMWH) or intravenous unfractionated heparin (IV UFH) for bridging of a subtherapeutic INR 60 days after implantation of a CF‐LVAD.
Rachel C. Klosko, Bryan Whitson, Brent Lampert, Eric McLaughlin, Libby Orzel   +4 more
wiley   +1 more source

Long‐term in vivo performance of silicone membrane lungs coated with novel methacryloyloxyethyl phosphorylcholine polymers: A pilot study

Artificial Organs, Volume 49, Issue 5, Page 842-851, May 2025.
This pilot study demonstrates the long‐term durability and reduced thrombogenicity of a novel MPC‐coated silicone membrane lung, highlighting its potential for extended use in extracorporeal respiratory support. Abstract Background This study was designed to evaluate the long‐term durability, oxygenation, and pressure loss of newly developed ...
Masaki Anraku, Ryo Yokoi, Shintaro Hara, Yuya Nobori, Keita Nakao, Kento Fukumoto, Toshiya Ono, Kazuaki Sato, Fumikazu Watanabe, Takashi Isoyama, Hiroaki Oshiyama, Minoru Ono, Jun Nakajima, Madoka Takai   +13 more
wiley   +1 more source

Perfusion Pressures and Weight Loss During Normothermic Machine Perfusion of Human Donor Livers

Artificial Organs, Volume 49, Issue 5, Page 820-830, May 2025.
Normothermic machine perfusion is used to preserve and assess donor livers before transplantation. Nevertheless, it can lead to reduced liver weight, which might be masked by edema when high perfusion pressures are used. Therefore, we encourage using the lowest pressures possible to reach adequate flows and oxygen supply during perfusion.
Bianca Lascaris, Silke B. Bodewes, Adam M. Thorne, Marius C. van den Heuvel, Robbert J. de Haas, Maarten W. N. Nijsten, Vincent E. de Meijer, Robert J. Porte   +7 more
wiley   +1 more source

Experimental Investigation of the Applicability of the Stress‐Based and Strain‐Based Hemolysis Models for Short‐Term Stress Peaks Typical for Rotary Blood Pumps

Artificial Organs, EarlyView.
Human blood hemolysis experiments with microchannels (I, II, III) were compared with simulations (A, B) by applying stress‐based and strain‐based hemolysis models. The stress‐based model showed a low applicability for short‐term stress peaks, while the strain‐based model, which considers the time‐dependent deformation of RBCs, shows more promising ...
Michael Lommel, Vera Froese, Henri Wolff, Nico Dirkes, Katharina Vellguth, Marek Behr, Ulrich Kertzscher   +6 more
wiley   +1 more source

In Vitro Comparison of Device‐Induced Hemolysis, Platelet Defects, and von Willebrand Factor Degradation Between the HeartMate 2 and HeartMate 3 Pumps

Artificial Organs, EarlyView.
This in vitro comparative study demonstrated that the HeartMate 3 pump has a superior overall hemocompatibility profile to the HeartMate 2 pump, underscoring the advantages of the maglev centrifugal pump design compared to the axial pump design. ABSTRACT Background Left ventricular assist devices (LVADs) have been utilized to maintain the circulatory ...
John Vandenberge, Dong Han, Wenji Sun, Shigang Wang, Douglas Tran, Nancy Kim, Kiersten Clark, Randy Perez, Bartley P. Griffith, Zhongjun J. Wu   +9 more
wiley   +1 more source

Simultaneous Ex Situ Normothermic Perfusion of Paired Kidneys in Pigs

Artificial Organs, EarlyView.
This pig model of simultaneous perfusion of paired kidneys in normothermia suggests that intra‐individual variation is relatively low, enabling one kidney to be employed as a reliable comparator of the other kidney for assessing treatments before kidney transplantation.
Margaux Navez, Nicholas Gilbo, Morgan Vandermeulen, Tiago Pinto Coelho, Pauline Erpicum, Marc Gilbert Lagny, Clarisse Malisoux, Claire Guarin, Gabriel Thierry, Pierre Delanaye, Etienne Cavalier, François Jouret, Olivier Detry   +12 more
wiley   +1 more source

Development of a Protocol for Long‐Term Ex Vivo Normothermic Machine Perfusion of Rodent Livers

Artificial Organs, EarlyView.
Long‐term normothermic machine perfusion (LT‐NMP) is the next revolution in liver transplantation and could support grafts for days, and potentially weeks. A rodent model of LT‐NMP is important for laboratory research, but has not been achieved until now. Our study describes a protocol for LT‐NMP of rodent livers.
Mark Ly, Daniel Babekuhl, Anita Niu, Paul Yousif, Chuanmin Wang, Ngee‐Soon Lau, Mark D. Gorrell, Geoffrey W. McCaughan, Michael Crawford, Carlo Pulitano   +9 more
wiley   +1 more source