Results 71 to 80 of about 149 (149)

Intraputaminal Delivery of Adeno‐Associated Virus Serotype 2–Glial Cell Line–Derived Neurotrophic Factor in Mild or Moderate Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Glial cell line–derived neurotrophic factor (GDNF) is required for development and survival of dopaminergic neurons. A previous trial evaluating lower‐dose adeno‐associated virus serotype 2–GDNF (AAV2‐GDNF) bilateral intraputaminal infusion in participants with advanced Parkinson's disease (PD) achieved 26% mean putaminal coverage ...
Amber D. Van Laar   +10 more
wiley   +1 more source

Dietary Adaptation of Non‐Heme Iron Absorption in Vegans: A Controlled Trial

open access: yesMolecular Nutrition &Food Research, EarlyView.
This study investigated how non‐heme iron from plant foods is absorbed in vegans compared to omnivores. After consuming pistachios, vegans showed a greater increase in blood iron levels. This may reflect physiological adaptations in iron metabolism, including lower hepcidin levels that promote iron absorption.
Miguel López‐Moreno   +6 more
wiley   +1 more source

A correction for modeling radial, spiral, and PROPELLER dynamic contrast‐enhanced data: Time‐averaged extended Tofts

open access: yesMagnetic Resonance in Medicine, EarlyView.
Abstract Purpose Dynamic contrast‐enhanced sequences (e.g. spiral, radial, PROPELLER MRI) often rely on oversampling the center of k‐space. Instead of the discrete snapshots obtained by Cartesian sampling, oversampling the k‐space center results in time‐averaging of the signal.
Natalia V. Korobova   +4 more
wiley   +1 more source

Unraveling the major role of vascular (R2') contributions to R2* signal relaxation at ultra‐high‐field MRI: A comprehensive analysis with quantitative gradient recalled echo in mouse brain

open access: yesMagnetic Resonance in Medicine, EarlyView.
Abstract Purpose Ultra‐high‐field (UHF) R2* relaxometry is often used for in vivo analysis of biological tissue microstructure without accounting for vascular contributions to R2* signal, that is, the BOLD signal component, and magnetic field inhomogeneities.
Joanna Im   +7 more
wiley   +1 more source

Improving quantitative BOLD–based measures of oxygen extraction fraction using hyperoxia BOLD–derived measures of blood volume

open access: yesMagnetic Resonance in Medicine, EarlyView.
Abstract Purpose Streamlined quantitative BOLD (sqBOLD) is a refinement of the quantitative BOLD (qBOLD) technique capable of producing noninvasive and quantitative maps of oxygen extraction fraction (OEF) in a clinically feasible scan time. However, sqBOLD measurements of OEF have been reported as being systematically lower than expected in healthy ...
Alan J. Stone, Nicholas P. Blockley
wiley   +1 more source

MRI‐based quantification of whole‐organ renal metabolic rate of oxygen during free‐breathing

open access: yesMagnetic Resonance in Medicine, EarlyView.
Abstract Purpose Renal metabolic rate of oxygen (rMRO2) reflects the kidney's metabolic efficiency, making it a potential biomarker for early‐stage kidney disease. This study introduces an ungated, free‐breathing MRI sequence in comparison to its breath‐hold counterpart to noninvasively measure whole‐organ rMRO2.
Nada Kamona   +7 more
wiley   +1 more source

A new prediction diagnosis model of incomplete Kawasaki disease based on data mining with big data

open access: yesPediatric Discovery, EarlyView.
In this study, based on a medical big data information mining approach, we mined the independent risk factors for incomplete Kawasaki disease prediction by comparing incomplete Kawasaki disease with related febrile illnesses and constructed an auxiliary diagnostic model used to predict incomplete Kawasaki disease.
Zhen Yang   +4 more
wiley   +1 more source

Anemia and retinopathy of prematurity: A narrative review

open access: yesPediatric Investigation, EarlyView.
Anemia in infants who are at greatest risk of developing severe retinopathy of prematurity is almost universal. There is plausible evidence in the literature correlating anemia with severe ROP. However, the relationship is complex, and further study is needed to better understand the potential molecular mechanisms for anemia‐associated ROP.
Minali Prasad   +3 more
wiley   +1 more source

Urinary Proteomics and Systems Biology Link Eight Proteins to the Higher Risk of Hypertension and Related Complications in Blacks Versus Whites

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Blacks are more prone to salt‐sensitive hypertension than Whites. This cross‐sectional analysis of a multi‐ethnic cohort aimed to search for proteins potentially involved in the susceptibility to salt sensitivity, hypertension, and hypertension‐related complications.
De‐Wei An   +22 more
wiley   +1 more source

Structural and Functional Characterization of the 28 kDa Structured Core of BmSA1, the Major Surface Antigen of Babesia Microti

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Babesiosis is a tick‐borne disease that poses a significant threat to animal health worldwide. In addition, climate change and the risk of human‐to‐human transmission through blood transfusion have made babesiosis an emerging disease in humans.
Assia Mouhand   +4 more
wiley   +1 more source

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