Results 261 to 270 of about 376,968 (292)

NIR‐Activatable Domino Cascade Catalysis Nanozyme Reactor for Multi‐Mechanism Synergistic Immunotherapy in Bladder Cancer

Advanced Science, EarlyView.
This study presents an intravesical delivery strategy of ferroptosis‐ and immunity‐inducing nanozyme‐loaded thermoresponsive hydrogels (FMCC@PNH) for enhanced bladder cancer therapy. Abstract Current intravesical therapies for bladder cancer after resection are limited by poor tissue penetration, off‐target effects, and insufficient efficacy.
Yongnan Jiang, Qingling Zhang, Yuhan Zhang, Xinlu Yu, Bo Jia, Yulong Dong, Yalong Wu, Kelong Fan, Xinquan Gu, Lei Ji, Wei Jiang, Bin Liu   +11 more
wiley   +1 more source

Hematologic immune-related adverse events in skin cancer patients treated with immune checkpoint inhibitors: a case series. [PDF]

Front Pharmacol
Falcone R, Frezzolini A, Bruni E, Verkhovskaia S, Carbone ML, Di Pietro FR, Chesi P, Piesco G, Cantonetti M, Marchetti P, De Galitiis F, Failla CM.   +11 more
europepmc   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Correction: Impact of daratumumab refractoriness on clinical outcomes following CAR T-cell therapy for relapsed refractory multiple myeloma

Blood Cancer Journal
Tara Sebastian, Sridevi Rajeeve, Tasmin Farzana, Ross Firestone, Eric Jurgens, Kevin Miller, Bruno Almeida Costa, Alexander Lesokhin, Carlyn Rose Tan, Gunjan Shah, Neha Korde, Heather Landau, Michael Scordo, Hani Hassoun, Kylee Maclachlan, Urvi Shah, Malin Hultcrantz, Andriy Derkach, Derkach Nemirovsky, Sergio Giralt, Saad Usmani, Sham Mailankody, Hamza Hashmi   +22 more
doaj   +1 more source

Long-Term Outcomes in Patients with Renal Systemic Light Chain Amyloidosis. [PDF]

Kidney Dis (Basel)
Ye Y, Guo J, Chen W, Wu X, Xu W, Huang X.   +5 more
europepmc   +1 more source

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

Advanced Science, EarlyView.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li, Jiaqiang Jiang, Yuping Zhou, Xinyuan Mao, Haotian Wen, Zhian Chen, Yutong Wang, Cong Huang, Yanfeng Hu   +8 more
wiley   +1 more source

Impact of daratumumab refractoriness on clinical outcomes following CAR T-cell therapy for relapsed refractory multiple myeloma

Blood Cancer Journal
Tara Sebastian, Sridevi Rajeeve, Tasmin Farzana, Ross Firestone, Eric Jurgens, Kevin Miller, Bruno Almeida Costa, Alexander Lesokhin, Carlyn Rose Tan, Gunjan Shah, Neha Korde, Heather Landau, Michael Scordo, Hani Hassoun, Kylee Maclachlan, Urvi Shah, Malin Hultcrantz, Andriy Derkach, David Nemirovsky, Sergio Giralt, Saad Usmani, Sham Mailankody, Hamza Hashmi   +22 more
doaj   +1 more source

Leukemia Cutis as a Transient Alarm Bell of Disease Progression in a Patient with Chronic Lymphocytic Leukemia under Watchful Waiting. [PDF]

Mediterr J Hematol Infect Dis
Landini S, Corrà A, Sanna A, Di Stefano G, Santi R, Caproni M, Verdelli A.   +6 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source