Results 81 to 90 of about 9,376,530 (330)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Acute graft-versus-host disease prophylaxis with methotrexate and cyclosporine after busulfan and cyclophosphamide in patients with hematologic malignancies [PDF]

, 1993
A von Bueltzingsloewen, Robert Bélanger, Claude Perreault, Y Bonny, DC Roy, Y Lalonde, J Boileau, Jeannine Kassis, R Lavallée, M Lacombe   +9 more
openalex   +3 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Network pharmacology-based investigation and experimental validation of the mechanism of metformin in the treatment of acute myeloid leukemia

European Journal of Medical Research
Metformin, a widely used anti-diabetic agent, has shown significant anti-cancer properties as reported in in various cancers, including acute myeloid leukemia.
Shaoyu Liu, Mingming Xu, Zhuofan Yang, Yangzi Li, Depei Wu, Xiaowen Tang   +5 more
doaj   +1 more source

CONTENT AND COMPOSITION OF THE MUCOPROTEIN FRACTION OF HUMAN SERUM (SEROMUCOID) IN DISEASE, WITH SPECIAL REFERENCE TO HEMATOLOGIC DISORDERS1 [PDF]

, 1958
Elly Moschides, Mario Stefanini, S.I. Magalini, Sten Kistner   +3 more
openalex   +1 more source

Urolithiasis in Patients Suffering from Malignant Hematologic Diseases

Yonsei medical journal, 2010
Purpose We performed this study in order to evaluate the incidence and characteristics of urolithiasis in patients with malignant hematologic diseases.
S. Kim, Sung Dae Kim, J. Yoo, Yong‐Hyun Cho, D. Sohn   +4 more
semanticscholar   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Evaluation of next-generation sequencing versus next-generation flow cytometry for minimal-residual-disease detection in Chinese patients with multiple myeloma

Discover Oncology
Purpose To evaluate the efficacy of next-generation sequencing (NGS) in minimal-residual-disease (MRD) monitoring in Chinese patients with multiple myeloma (MM). Methods This study analyzed 60 Chinese MM patients. During MRD monitoring in these patients’
Mo Zhou, Yan Chen, Yanlei Gong, Mingqing Zhu, Jiannong Cen, Jinlan Pan, Lingzhi Yan, Jingjing Shang, Song Jin, Xiaolan Shi, Weiqin Yao, Shuang Yan, Depei Wu, Suning Chen, Chengcheng Fu, Li Yao   +15 more
doaj   +1 more source

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

Hematologic Diseases. New Directions in Therapy [PDF]

, 1977
Peter Curt Ungaro, Bruce R. Canaday
openalex   +1 more source