Results 81 to 90 of about 87,295 (197)

Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis

Advanced Science, EarlyView.
In this study, a mechanical biomimetic nanocomposite is developed, guided by photoacoustic imaging, to achieve highly efficient and safe thrombolysis through the synergistic effects of photothermal therapy and pharmacological intervention. Most notably, the nanoparticle improves the microenvironment of arterial thrombi, marked by high shear stress and ...
Ying Li, Qi Xiang, Yan Zhang, Fuxue Luo, Yunfang Wu, Haitao Ran, Yang Cao   +6 more
wiley   +1 more source

Reversal of Stress‐Induced PIEZO1 Elevation with Mechanically Adapted Epicardial Patch for Myocardial Infarction Treatment

Advanced Science, EarlyView.
This work identifies fine‐tuning the expression of PIEZO1 as a critical molecular mechanism underlying the treatment of myocardial infarction by mechanically adapted cardiac patches, which can support the clinical translation of cardiac patch devices.
Yuwen Lu, Sibo Jiang, Ting Shen, Yuan Zhang, Chengbin He, Yun Gao, Liyin Shen, Qiao Jin, Yuting Zhao, Ping Liang, Chaochen Wang, Hongjie Hu, Jin He, Kaicheng Deng, Shuo Wang, Yunhe Chen, Jun Ling, Yang Zhu, Lenan Zhuang   +18 more
wiley   +1 more source

The role of the pulmonary function laboratory in the management of hematologic diseases. [PDF]

J Bras Pneumol
Neder JA, O'Donnell DE, Berton DC.
europepmc   +1 more source

Safety of rehabilitation interventions for patients with hematologic diseases associated with low blood counts-verification focusing on blood cancer. [PDF]

J Phys Ther Sci, 2021
Moriyama T, Takami A, Makino M.
europepmc   +1 more source

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source

Clinical Value of Tocilizumab in Reducing Mortality in Refractory Septic Shock in Children with Hematologic and Non-Hematologic Diseases. [PDF]

Cells
Lee EP, Lin JJ, Chen SH, Chan OW, Su YT, Hsiao MR, Hsia SH, Wu HP.   +7 more
europepmc   +1 more source

Fatal hemorrhagic pneumonia in patients with hematologic diseases and Stenotrophomonas maltophilia bacteremia: a retrospective study. [PDF]

BMC Infect Dis, 2021
Zhu L, Wang L, Zhang Y, Chen R, Li X, Sun J, Zhou, Zhu M, Zheng X, Li L, Zhu J, Xie M, Yang X, Yu W, Tong H, Zhu H, Xie W, Jin J, Ye X.   +18 more
europepmc   +1 more source

Targeted Dual‐Responsive Liposomes Co‐Deliver Jolkinolide B and Ce6 to Synergistically Enhance the Photodynamic/Immunotherapy Efficacy in Gastric Cancer through the PANoptosis Pathway

Advanced Science, EarlyView.
Schematic model of CJP–TiN liposomes for gastric cancer (GC) treatment. Internalizing RGD peptide (iRGD) targets tumor cells, while Chlorin e6 (Ce6) generates reactive oxygen species (ROS). Jolkinolide B (JB) activates the PANoptosis pathway via caspase‐8, enhancing GC cell death and immune response, transforming “cold tumors” into “hot tumors” by ...
Chenhui Ma, Lei Gao, Kewei Song, Baohong Gu, Bofang Wang, Yang Yu, Xueyan Wang, Xuemei Li, Jike Hu, Weigao Pu, Yunpeng Wang, Na Wang, Dedai Lu, Zhijian Han, Hao Chen   +14 more
wiley   +1 more source

The Bloody Crossroads: Interactions between Periodontitis and Hematologic Diseases. [PDF]

Int J Mol Sci
Łobacz M, Mertowska P, Mertowski S, Kozińska A, Kwaśniewski W, Kos M, Grywalska E, Rahnama-Hezavah M.   +7 more
europepmc   +1 more source