Results 71 to 80 of about 2,266,477 (255)

Rare diseases and orphan drugs: Latvian story [PDF]

, 2014
Publisher Copyright: © 2014 Logviss et al.; licensee BioMed Central Ltd.Background: Ten years have passed since Latvia became a Member State of the EU in 2004.
Logviss, Konstantins, Krievins, Dainis, Purvina, Santa   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Introduction to a review series on emerging immunotherapies for hematologic diseases.

, 2018
Immune therapies are fast becoming paradigm-changing treatment options for patients with hematologic cancers. The field has grown exponentially as it expands to nonmalignant blood diseases. This Perspective article introduces the review series describing
Sophie Paczesny, Pavletic, Steven Z., Steven Z. Pavletic, Paczesny, Sophie, Bollard, Catherine M., Bollard, Catherine M, Catherine M. Bollard, Pavletic, Steven Z   +7 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Hematologic Abnormalities and Diseases Associated with Moderate-to-Marked Basophilia in a Large Cohort of Dogs

, 2023
Basophilia is a rare hematologic finding in dogs. This research aimed to describe the hematologic and clinical characteristics of dogs with moderate-to-marked basophilia. CBC reports with blood smear examinations from dogs presented to the North Carolina
Elizabeth Held, Hiroyuki Mochizuki
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A consensus document for the clinical management of invasive fungal diseases in pediatric patients with hematologic cancer and/or undergoing hematopoietic stem cell transplantation in Brazilian medical centers

, 2019
In the present paper we summarize the suggestions of a multidisciplinary group including experts in pediatric oncology and infectious diseases who reviewed the medical literature to elaborate a consensus document (CD) for the diagnosis and clinical ...
Loggetto, Sandra Regina, Loggetto, Sandra, Macedo, Carla Renata Pacheco Donato, Gregianin, Lauro, Castro Junior, Cláudio Galvão de, Bonfim, Carmem, Tostes, Vivian Siqueira, Macedo, Carla Renata Donato, Daudt, Liane Esteves, Bonfim, Carmem Maria Sales, Carlesse, Fabianne, Melo, Analy Salles de Azevedo, Dutra, Álvaro Pimenta, Carlesse, Fabianne Altruda de Moraes Costa, Gregianin, Lauro José, Lee, Maria Lucia de Martino, Batista, Marjorie Vieira, Colombo, Arnaldo Lopes, Abramczyk, Marcelo Luiz, Tostes, Vivian, Simões, Belinda, Galvão de Castro Junior, Cláudio, Seber, Adriana, Abramczyk, Marcelo, Simões, Belinda Pinto, Lederman, Henrique Manoel, Benites, Eliana   +26 more
core   +2 more sources

A novel fusion gene of NUP98::CYP2F2P in myeloid neoplasm

Annals of Hematology
We report the first identification of an NUP98::CYP2F2P gene fusion in a 60-year-old woman presenting with pancytopenia and 6.5% bone marrow blasts. CYP2F2P, a cytochrome P450 pseudogene, represents the first reported pseudogene partner in the CYP family
Wusixian Huang, Fenghong Zhang, Jundan Xie, Chunxiao Wu, Qian Wang, Lijun Wang, Qinrong Wang, Suning Chen   +7 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source