Results 11 to 20 of about 95,219 (308)

The Genetic Makeup of Myeloproliferative Neoplasms: Role of Germline Variants in Defining Disease Risk, Phenotypic Diversity and Outcome

Cells, 2021
Myeloproliferative neoplasms are hematologic malignancies typified by a substantial heritable component. Germline variants may affect the risk of developing a MPN, as documented by GWAS studies on large patient cohorts. In addition, once the MPN occurred,
Elena Masselli, Giulia Pozzi, Cecilia Carubbi, Marco Vitale   +3 more
doaj   +1 more source

Screening for SARS-COV-2 Using RT-qPCR in Patients with Hematologic Neoplasms Receiving Chemotherapy

Prague Medical Report, 2023
It has been recommended that patients with leukaemias and lymphomas undergo universal screening for SARS-COV-2 using RT-qPCR before each treatment on the grounds of their high risk of experiencing severe forms of COVID-19.
Ignacio Martín Santarelli, Mariela Sierra, Sofía Isabel Fernández   +2 more
doaj   +1 more source

GENETIC PREDISPOSITION TO HEMATOLOGIC MALIGNANCIES IN CHILDHOOD AND ADOLESCENCE

Mediterranean Journal of Hematology and Infectious Diseases, 2023
Advances in molecular biology and genetic testing have greatly improved our understanding of the genetic basis of hematologic malignancies and have enabled the identification of new cancer predisposition syndromes. The recognition of a germline mutation
Francesco Fabozzi, Angela Mastronuzzi
doaj   +1 more source

Immunotherapy in Pediatric Hematologic Malignant Neoplasms

Clinical Pediatric Hematology-Oncology, 2020
Childhood acute leukemia has achieved tremendous treatment outcome improvement over the past several decades. Given that pediatric leukemia remains the most common type of childhood malignant tumors, there are still unmet needs in relapsed/refractory ...
Kyung Taek Hong
doaj   +1 more source

An intriguing coexistence of cutaneous and systemic mastocytosis with atypical chronic myeloid leukemia: An associated hematologic neoplasm (SM-AHN)

Journal of Applied Hematology, 2021
Systemic mastocytosis (SM) characterized by focal or diffuse infiltrates of neoplastic mast cells can range from indolent cutaneous disease to aggressive systemic disease.
B R Rajalakshmi, Vijaya Basavaraj
doaj   +1 more source

Enhanced clinical assessment of hematologic malignancies through routine paired tumor and normal sequencing

Nature Communications, 2023
Genomic profiling of hematologic malignancies has augmented our understanding of variants that contribute to disease pathogenesis and supported development of prognostic models that inform disease management in the clinic.
Ryan N. Ptashkin, Mark D. Ewalt, Gowtham Jayakumaran, Iwona Kiecka, Anita S. Bowman, JinJuan Yao, Jacklyn Casanova, Yun-Te David Lin, Kseniya Petrova-Drus, Abhinita S. Mohanty, Ruben Bacares, Jamal Benhamida, Satshil Rana, Anna Razumova, Chad Vanderbilt, Anoop Balakrishnan Rema, Ivelise Rijo, Julie Son-Garcia, Ino de Bruijn, Menglei Zhu, Sean Lachhander, Wei Wang, Mohammad S. Haque, Venkatraman E. Seshan, Jiajing Wang, Ying Liu, Khedoudja Nafa, Laetitia Borsu, Yanming Zhang, Umut Aypar, Sarah P. Suehnholz, Debyani Chakravarty, Jae H. Park, Omar Abdel-Wahab, Anthony R. Mato, Wenbin Xiao, Mikhail Roshal, Mariko Yabe, Connie Lee Batlevi, Sergio Giralt, Gilles Salles, Raajit Rampal, Martin Tallman, Eytan M. Stein, Anas Younes, Ross L. Levine, Miguel-Angel Perales, Marcel R. M. van den Brink, Ahmet Dogan, Marc Ladanyi, Michael F. Berger, A. Rose Brannon, Ryma Benayed, Ahmet Zehir, Maria E. Arcila   +54 more
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Molecular Pathways in Clonal Hematopoiesis: From the Acquisition of Somatic Mutations to Transformation into Hematologic Neoplasm

Life, 2022
Hematopoietic stem cell aging, through the acquisition of somatic mutations, gives rise to clonal hematopoiesis (CH). While a high prevalence of CH has been described in otherwise healthy older adults, CH confers an increased risk of both hematologic and
Charles Gaulin, Katalin Kelemen, Cecilia Arana Yi   +2 more
doaj   +1 more source

LNK (SH2B3): paradoxical effects in ovarian cancer. [PDF]

, 2015
LNK (SH2B3) is an adaptor protein studied extensively in normal and malignant hematopoietic cells. In these cells, it downregulates activated tyrosine kinases at the cell surface resulting in an antiproliferative effect. To date, no studies have examined
Chien, W, Ding, L-W, Doan, NB, Dong, X-M, Garg, M, Gery, S, Hattori, N, Huang, RY-J, Koeffler, HP, Lin, D-C, Liu, L-Z, Meng, X, Said, JW, Sun, Q-Y, Tang, K, Xiao, J-F, Yang, H   +16 more
core   +2 more sources

Female Genital Tract Involvement in Acute Lymphoblastic Leukemia: A Rare Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2016
Female Genital Tract (FGT) involvement with hematologic neoplasms is uncommon and the hematologic malignancies which involve the female genital organs are usually non-Hodgkin’s lymphoma.
Vikram Narang, Amit Dhiman, Bhavna Garg, Neena Sood   +3 more
doaj   +1 more source

Cancer-associated fibroblasts in hematologic malignancies: elucidating roles and spotlighting therapeutic targets

Frontiers in Oncology, 2023
Hematologic malignancies comprise a diverse range of blood, bone marrow, and organ-related disorders that present significant challenges due to drug resistance, relapse, and treatment failure.
Ziyang Ding, Run Shi, Weikang Hu, Lei Tian, Rong Sun, Yang Wu, Xiaoyan Zhang   +6 more
doaj   +1 more source