The role of JAK2 abnormalities in hematologic neoplasms. [PDF]
Hematology Reports, 2009 In 2005, an activating mutation in the Janus kinase 2 (JAK2) was identified in a significant proportion of patients with myeloproliferative neoplasms, mainly polycythemia vera, essential thrombocythemia and primary myelofibrosis.
Mohammed Khalid Alabdulaali
doaj +4 more sources
Autoimmune Complications in Hematologic Neoplasms. [PDF]
Cancers (Basel), 2021 Autoimmune cytopenias (AICy) and autoimmune diseases (AID) can complicate both lymphoid and myeloid neoplasms, and often represent a diagnostic and therapeutic challenge. While autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP) are well known, other rarer AICy (autoimmune neutropenia, aplastic anemia, and pure red cell aplasia) and ...
Barcellini W, Giannotta JA, Fattizzo B.
europepmc +7 more sources
Hematological Neoplasms with Eosinophilia [PDF]
Cancers, 2023 Eosinophils in peripheral blood account for 0.3–5% of leukocytes, which is equivalent to 0.05–0.5 × 109/L. A count above 0.5 × 109/L is considered to indicate eosinophilia, while a count equal to or above 1.5 × 109/L is defined as hypereosinophilia. In bone marrow aspirate, eosinophilia is considered when eosinophils make up more than 6% of the total ...
Rosario M. Morales-Camacho +4 more
openaire +6 more sources
EBF1, PAX5, And MYC: Regulation on B Cell Development and Association With Hematologic Neoplasms [PDF]
Frontiers in ImmunologyDuring lymphocyte development, a diverse repertoire of lymphocyte antigen receptors is produced to battle against pathogens, which is the basis of adaptive immunity.
Li L, Zhang D, Cao X.
exaly +4 more sources
The Genetic Makeup of Myeloproliferative Neoplasms: Role of Germline Variants in Defining Disease Risk, Phenotypic Diversity and Outcome [PDF]
Cells, 2021 Myeloproliferative neoplasms are hematologic malignancies typified by a substantial heritable component. Germline variants may affect the risk of developing a MPN, as documented by GWAS studies on large patient cohorts. In addition, once the MPN occurred,
Elena Masselli +3 more
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GENETIC PREDISPOSITION TO HEMATOLOGIC MALIGNANCIES IN CHILDHOOD AND ADOLESCENCE [PDF]
Mediterranean Journal of Hematology and Infectious Diseases, 2023 Advances in molecular biology and genetic testing have greatly improved our understanding of the genetic basis of hematologic malignancies and have enabled the identification of new cancer predisposition syndromes. The recognition of a germline mutation
Francesco Fabozzi, Angela Mastronuzzi
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Quality of life and functional capacity during the treatment of hematologic neoplasms [PDF]
Fisioterapia em Movimento, 2018 Introduction: Cancer is a serious pathology with a high incidence and complex diagnoses. Emotional and environmental factors, the deleterious effects of these, and lifestyle affect different outcomes.
Monique Vanderlinde de Souza +3 more
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Cancer-associated fibroblasts in hematologic malignancies: elucidating roles and spotlighting therapeutic targets [PDF]
Frontiers in Oncology, 2023 Hematologic malignancies comprise a diverse range of blood, bone marrow, and organ-related disorders that present significant challenges due to drug resistance, relapse, and treatment failure.
Ziyang Ding +6 more
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Cellular and Molecular Effects of Eribulin in Preclinical Models of Hematologic Neoplasms. [PDF]
Cancers (Basel), 2022 Despite the advances in understanding the biology of hematologic neoplasms which has resulted in the approval of new drugs, the therapeutic options are still scarce for relapsed/refractory patients.
Vicari HP +3 more
europepmc +2 more sources
The origin of epithelial neoplasms after allogeneic stem cell transplantation [PDF]
Haematologica, 2006 We analyzed five women, who have developed epithelial neoplasms after sex-mismatched stem cell transplants. Using in situ hybridization for sex chromosome-specific DNA probes and immunohistochemistry we identified the origin of the tumor cells.
MJ Smith +3 more
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