Results 191 to 200 of about 584,870 (306)

Capture and Culture of Circulating Tumor Cells Using a Biodegradable 3D Scaffold for Patient‐Derived Xenograft Construction

Advanced Science, EarlyView.
A self‐supporting, biocompatible, and biodegradable 3D cellulose scaffold has been developed for efficient isolation and in situ expansion of circulating tumor cells (CTCs) from patient blood. Subsequently, the 3D cellulose scaffold with cultured CTCs is directly implanted into immunodeficient mice for constructing patient CTC‐derived xenograft (CDX ...
Yi‐Ke Wang, Ming Wang, Min Liu, Yi‐Jing Chen, Li‐Li Xu, Jin‐Ping Zhou, Fu‐Bing Wang, Shi‐Bo Cheng, Min Xie, Wei‐Hua Huang   +9 more
wiley   +1 more source

Comparable outcomes of HSCT up-front and after failure of IST in pediatric aplastic anemia in recent years. [PDF]

Blood Adv
Andresen F, Yoshimi A, Bader P, Bierings M, Bod'ová I, Bordon V, Buechner J, Burkhardt B, Dworzak M, Erlacher M, Kállay K, Labarque V, Locatelli F, Malone A, Masmas T, Müller I, Nöllke P, Schmugge M, Pawelec K, Sedlacek P, Sevilla J, Smith O, Stary J, Niemeyer C, Strahm B.   +24 more
europepmc   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Dietary dose response of Curcuma longa essential oil on the growth and hematological performance of Nile tilapia [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
G.B. Ferreira, P. Kopitski, A.O. Machado, A. Chaaban, D.D. Schleder, A. Jatobá, J.I.A. Andrade   +6 more
doaj   +1 more source

The optimal conditioning intensity of stem cell transplantation for acute myeloid leukemia in complete remission. [PDF]

Ann Hematol
Shimomura Y, Komukai S, Kitamura T, Sobue T, Yamasaki S, Kondo T, Mizuno S, Harada K, Shingai N, Tanaka M, Ito A, Nishida T, Ohigashi H, Uchida N, Matsuoka KI, Kanda Y, Onizuka M, Kawakita T, Hiramoto N, Sawa M, Fukushima K, Kanda J, Fukuda T, Atsuta Y, Yanada M.   +24 more
europepmc   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Impact of venetoclax trough levels on safety and efficacy in the treatment of acute myeloid leukemia. [PDF]

Sci Rep
Hayashi H, Yamagiwa T, Kanda J, Ishikawa T, Sawa M, Miyahara Y, Tachibana T, Watanabe M, Ueda Y, Tsutsumi Y, Imada K, Fujiwara SI, Toubai T, Yoshifuji K, Hirata H, Kawabata H, Tsuji M, Wakita S, Yokoyama H, Kitano T, Murai K, Kataoka Y, Kawata E, Kimura SI, Yamamoto R, Miyao K, Nakayama D, Izumi A, Kawata T, Onda Y, Sakamoto T, Mizumoto C, Kitawaki T, Yamashita K, Yonezawa A, Kawakami T, Nakagawa S, Taniguchi R, Terada T, Takaori-Kondo A.   +39 more
europepmc   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Underrated, Unvaccinated, Untreated: A Multinational Registry Analysis of Human Metapneumovirus in Hematological Malignancy, Insights From EPICOVIDEHA/EPIRESEHA Registry. [PDF]

Open Forum Infect Dis
Salmanton-García J, Marchesi F, Mackenzie E, Heras-Fernando I, Falces-Romero I, Vena A, Garcia-Vidal C, Weinbergerová B, Sgherza N, Piukovics K, Méndez GA, Leotta D, López-García A, Farina F, Erben N, Bilgin YM, Biernat MM, Petzer V, Magliano G, Drgoňa Ľ, Víšek B, Soto-Silva A, Samarkos M, Navrátil M, Lahmer T, Fracchiolla NS, Vinh DC, Prezioso L, Pantić N, Khostelidi S, Khedr RA, Eisa N, Dargenio M, Buquicchio C, Pinczés LI, Papa MV, García-Ramírez P, Dąbrowska-Iwanicka A, Cuccaro A, Čolović N, Čerňan M, Van Praet J, Valković T, Plantefeve G, Merelli M, Labrador J, Kolditz M, Glenthøj A, Espigado I, Erdem S, Drozd-Sokołowska J, Delia M, Cerchione C, Cattaneo C, Batinić J, Avendaño A, Almasari A, Prin R, Nappi D, Musto P, Hersby DS, Arellano E, Callejas-Charavia M, Varricchio G, Mitrović M, Anastasopoulou AN, Wolf D, Cordoba R, Romano A, Aiello TF, Bavastro M, Limongelli A, Giordano A, Brunetti SC, Nguyen K, Van Der Ven L, Pagano L, Cornely OA.   +77 more
europepmc   +1 more source

Beyond Catalytic Therapy: Copper‐Paeonol Nanozymes Disrupt Fascin‐Mediated Actin Bundling to Suppress Tumor Growth and Metastasis

Advanced Science, EarlyView.
Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang, Huajun Li, Yisen Wang, Jie Xiang, Lei Fan, Shengzhe Zhang, Lizeng Gao, Hua Dai, Juqun Xi   +8 more
wiley   +1 more source