Results 251 to 260 of about 461,852 (357)

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, EarlyView.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

Early Antifungal Treatment in Immunocompromised Patients, Including Hematological and Critically Ill Patients. [PDF]

J Fungi (Basel)
Klyasova G, Solopova G, Abdalla J, Popova M, Ar MC, Sungur M, Fakih RE, Almaghrabi RS, Akova M.   +8 more
europepmc   +1 more source

[Nutritional status in patients first hospital admissions service hematology National Cancer Institute].

, 2014
Eréndira Baltazar Luna, L. I. Omaña Guzmán, Luis Ortiz-Hernández, S. A. Ñamendis-Silva, L. De Nicola Delfin   +4 more
openalex   +2 more sources

Interferon‐Driven Biomarkers and Synergistic Therapy for PRMT5 Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer exhibits variable sensitivity to PRMT5 inhibition. Basal interferon signaling is identified as a key biomarker of response. PARP inhibition with olaparib induces IFN signaling, sensitizing resistant TNBC cells to PRMT5 inhibitors.
Ziwen Zhang, Sheyu Zhang, Lu Guo, Yichun Pan, Juan Huang, Yishuai Ji, Jiaqi Tao, Yong Wei, Xiaojia Wang, Qin Wu   +9 more
wiley   +1 more source

Liberalizing hospital proximity requirements for children/young adults with low-burden B-ALL receiving tisagenlecleucel. [PDF]

Blood Adv
Appell LE, Baggott C, Nguyen K, Prabhu S, Pacenta H, John S, Fabrizio VA, Phillips CL, Rossoff J, Talano JA, Moskop A, Phelan R, Baumeister SHC, Verneris MR, Hall EM, Myers GD, Karras NA, Cooper SL, Qayed M, Raikar SS, Winestone L, Hermiston M, Satwani P, Krupski C, Keating AK, Friedman DN, Curran KJ, Hoover A, MacMillan ML, Ebens CL, Ramgopal A, Rahrig AL, Mackall CL, Laetsch TW, McNerney K, Schultz LM.   +35 more
europepmc   +1 more source

[Hotspot report of 56th American Society of Hematology Annual Meeting: Hodgkin lymphoma].

, 2015
Fei Wang, Lei Fan, Wei Xu, Jianyong Li
openalex   +2 more sources

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
ABSTRACT Multiple myeloma (MM) is a hematologic malignancy driven by clonal expansion of malignant plasma cells. Despite the long‐term disease control achieved with immunotherapies in some patients, treatment resistance remains a major cause of disease relapse.
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Building a transdisciplinary network to improve survival in children with cancer in Colombia: seeds to forests. [PDF]

Rev Panam Salud Publica
Portilla A, Lopez-Baron E, Ramirez O, Fonseca E, Bolivar S, Piedrahita V, Quijano-Lievano ML, González K, Ardila J, Montenegro P, Camacho-Moreno G, Piña M, Lopera J, Suarez G, Aguilar-Mejia J, Coronell-Rodriguez W, Arango C, Pabon E, Grillo K, Tovar-Padua L, Lauzardo M, Aristizabal P.   +21 more
europepmc   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source