Results 111 to 120 of about 5,668,323 (316)

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Hematopoietic Stem Cell Transplantation: Recent Advances

Hematopoietic progenitor cell transplantation was the first form of cell therapy to be developed [...
Alessandra Cupri, Salvatore Leotta, Giuseppe Milone   +2 more
core   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Backgrounds of 182 patients who underwent hematopoietic stem cell transplantation.

, 2018
Backgrounds of 182 patients who underwent hematopoietic stem cell transplantation.
Gota Sudo (5570936), Daisuke Hirayama (4396837), Tomoya Iida (4732995), Toshiyuki Kubo (5570939), Masanori Nojima (52788), Hiroo Yamano (5570942), Kentaro Yamashita (796584), Hiroshi Nakase (783451), Sae Ohwada (5570933)   +8 more
core   +1 more source

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Epigenetic modulation of NKG2D ligands enhances NKG2D-CAR T cell efficacy in neuroblastoma

Journal of Translational Medicine
Background Neuroblastoma (NB) is the most common extracranial solid tumor in children and is associated with high mortality despite aggressive multimodal therapies for high-risk patients.
Alfonso Navarro-Zapata, María Octavia De Santisteban, Rita María Regojo-Zapata, Marta Ibáñez-Navarro, Laura Clares-Villa, Marta de la Hoz, Andrea Romero, Carmen Mestre-Durán, Karima Al-Akioui Sanz, Halin Bareke, Sara Naharro, Jordi Minguillón, Lidia Pertíñez, Natalia Riestra, Mireia Masot, Carla Martín-Cortázar, Cristina Aguirre-Portolés, Cristina Ferreras, Adriana Mañas, Antonio Pérez-Martínez, Lucía Fernández Casanova   +20 more
doaj   +1 more source

Autologous hematopoietic stem cell transplantation for pediatric autoimmune neurologic disorders

Autologous hematopoietic stem cell transplantation (aHSCT) may be effective in carefully selected pediatric patients with multiple sclerosis (MS), neuromyelitis optica (NMO), and chronic inflammatory demyelinating polyneuropathy (CIDP).
Greco, R., Burman, Joachim,, Kirgizov, Kirill, Greco, Raffaella, Kirgizov, K., Burman, J., Snowden, J.A., Snowden, John A.   +7 more
core   +1 more source

Allogeneic Hematopoietic Stem Cell Transplantation in the Treatment of Human C1q Deficiency: The Karolinska Experience.

, 2015
Human C1q deficiency is associated with systemic lupus erythematosus (SLE) and increased susceptibility to severe bacterial infections. These patients require extensive medical therapy and some develop treatment-resistant disease. Because C1q is produced
Ahlin, Anders,, Hagelberg, Stefan,, Schiller, Bodil,, Schiller, Bodil, Olsson, Richard F.,, Ringden, Olle,, Olsson, Richard F, Hagelberg, Stefan, Truedsson, Lennart,, Åhlin, Anders, Lund University., Ringdén, Olle, Truedsson, Lennart, Truedsson, L, Hagelberg, S, Olsson, RF, Schiller, B, Ahlin, A, Ringden, O   +18 more
core   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source