Results 141 to 150 of about 5,668,323 (316)

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Co‐Mutation of ASXL1 and KRAS Defines a Novel Ultra‐Adverse‐Risk Subtype of Acute Myeloid Leukemia in a Large‐Scale Cohort

Cancer Medicine
Background ASXL1 mutation acute myeloid leukemia represents a clinically aggressive subtype with heterogeneous outcomes. Current evidence remains inconclusive regarding the prognostic relevance of the KRAS mutation partner in AML with ASXL1 mutation. The
Yijing Zhao, Ting Zhao, Feifei Tang, Xiaodong Mo, Yingjun Chang, Xiaosu Zhao, Lanping Xu, Yu Wang, Xiaohui Zhang, Hao Jiang, Qian Jiang, Xiaojun Huang, Yuqian Sun   +12 more
doaj   +1 more source

Hematopoietic stem cell transplantation in rheumatic diseases

, 1999
The concept of using hematopoietic stem cell transplantation to treat patients with autoimmune disease was first provided by animal studies and anecdotal case reports. Advances over recent years in autologous hematopoietic stem cell transplantation, most
Brooks, P. M., Snowdon, J. A.
core   +1 more source

CaMKIIδ Phosphorylates AUP1 to Promote Pancreatic Tissue Repair and Acinar‐to‐Ductal Metaplasia Formation via Mediating PERK‐Dependent Unfolded Protein Responses

Advanced Science, EarlyView.
CaMKIIδ–AUP1 signaling maintains PERK‐dependent ER homeostasis during ADM‐mediated pancreatic repair. ABSTRACT Pancreatic repair after acute pancreatitis (AP) is essential for restoring tissue integrity, but the intrinsic mechanisms coordinating acinar plasticity and regeneration remain poorly understood.
Yonghao Chen, Ziying Han, Zihan Yang, Jie Wu, Kaixin Peng, Xiuli Zhang, Bintao Qiu, Jianqiang Wu, Xiaomin Hu, Dong Wu, Li Wen   +10 more
wiley   +1 more source

The Presence and Percentage of Circulating Nucleated Red Blood Cells Reveal Distinct Characteristics in Adults With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Although circulating nucleated red blood cells (cNRBCs) have previously been detected in patients with sickle cell disease (SCD), their prevalence and clinical significance during steady‐state disease have not been established. We retrospectively analyzed 270 adults with an SS or Sβ0‐thalassemia genotype.
Ugo Boccadifuoco, Ivan Lerner, Auria Godard, Luc Darnige, Laure Joseph, Wassim El Nemer, Geoffrey Cheminet, Jean‐Benoit Arlet   +7 more
wiley   +1 more source

hematopoietic stem cell transplantation (Faculty of Medicine, phase IV)

, 2018
hematopoietic stem cell transplantation (Faculty of Medicine, phase ...
Kuskonmaz, Baris
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Allogeneic Hematopoietic Cell Transplantation for Adult Chronic Myelomonocytic Leukemia

, 2017
•Hematopoietic cell transplantation is an important and potentially curative treatment option for patients with chronic myelomonocytic leukemia•Higher chronic myelomonocytic leukemia–specific prognostic scores, lower performance status, and bone marrow ...
Gupta, Vikas, Kindwall-Keller, Tamila,, Alyea, Edwin,, Bredeson, Christopher,, Akpek, Gorgun,, Malone, Adriana,, Saber, Wael,, Wirk, Baldeep,, Marks, David I.,, Inamoto, Yoshihiro, Saad, Ayman, Kalaycio, Matt, Hu, Zhen-Huan, Sobecks, Ronald,, Bajel, Ashish,, Beitinjaneh, Amer, Aljurf, Mahmoud, Cahn, Jean-Yves,, Hu, Zhen-Huan,, Wiernik, Peter H.,, Cortes, Jorge, Nishihori, Taiga, Akpek, Gorgun, Ahn, Kwang Woo, Saber, Wael, Bredeson, Christopher, Reshef, Ran,, Aljurf, Mahmoud,, Kalaycio, Matt,, Beitinjaneh, Amer,, Marks, David I, Olsson, Richard F.,, Gerds, Aaron,, Olsson, Richard F, Malone, Adriana, Gergis, Usama,, Sabloff, Mitchell,, Sobecks, Ronald, Alyea, Edwin, Nishihori, Taiga,, Inamoto, Yoshihiro,, Hamadani, Mehdi,, Kindwall-Keller, Tamila, Gergis, Usama, Popat, Uday,, Bajel, Ashish, Daly, Andrew, Gerds, Aaron, Rizzieri, David, Sabloff, Mitchell, Tallman, Martin, Litzow, Mark R, Savani, Bipin N.,, Savoie, Mary Lynn, Rowe, Jacob M, Reshef, Ran, Litzow, Mark R.,, Wiernik, Peter H, Grunwald, Michael R.,, Daly, Andrew,, Rizzieri, David,, Savoie, Mary Lynn,, Hsu, Jack W.,, Majhail, Navneet,, Rowe, Jacob M.,, Gupta, Vikas,, Popat, Uday, Cortes, Jorge,, Maziarz, Richard, Ustun, Celalettin, Savani, Bipin N, Ahn, Kwang Woo,, Copelan, Edward, Cahn, Jean-Yves, Majhail, Navneet, Ustun, Celalettin,, Tallman, Martin,, Copelan, Edward,, Liu, Hien Duong, Hsu, Jack W, Wirk, Baldeep, Hamadani, Mehdi, Grunwald, Michael R, Maziarz, Richard,, Saad, Ayman,, Sabloff, M, Hamadani, M, Wirk, B, Hien, DL, Beitinjaneh, A, Grunwald, MR, Ahn, KW, Rizzieri, D, Nishihori, T, Hu, Z-H   +94 more
core   +1 more source

Chromosomal Abnormalities, Drug Sensitivity and Resistance in Hematological Malignancies: A Comprehensive Overview by the Francophone Group of Hematological Cytogenetics (GFCH)

American Journal of Hematology, EarlyView.
ABSTRACT Chromosomal abnormalities have a major clinical impact on hematological malignancies, particularly with regard to treatment strategies. To preserve and consolidate fundamental knowledge in this rapidly evolving field, the Francophone Group of Hematological Cytogenetics (Groupe Francophone de Cytogénétique Hématologique, GFCH) conducted a ...
Florence Nguyen‐Khac, Audrey Bidet, Elise Chapiro, Nathalie Douet‐Guilbert, Jean‐Baptiste Gaillard, Nada Assaf, Nathalie Auger, Hend Chaker, Jasmine Chauzeix, Inge Govaerts, Hippolyte Guérineau, Christine Lefebvre, Pauline Roynard, Hélène Guermouche, Lucienne Michaux, Marie‐Bérengère Troadec, Lauren Véronèse   +16 more
wiley   +1 more source

Mapping Hematopoietic Fate after Transplantation

Hematopoietic stem and progenitor cells (HSPCs) form the foundation of lifelong blood cell production and immune function. Understanding their fate, including how they differentiate, self-renew, and respond to environmental cues has long been a ...
Hurwitz, Stephanie N.
core   +1 more source

Cell separation and cryopreservation of cord blood fractions for immunotherapeutic applications [PDF]

, 2014
In 2008 Anthony Nolan opened the UK’s first public umbilical cord blood (CB) bank (Anthony Nolan Cell Therapy Centre, ANCTC) in which CB is stored for haematopoietic stem cell (HSC) transplantation. Due to strict quality thresholds, the majority of units
Fry, LJ
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