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Hematopoietic-Cell Transplantation at 50

New England Journal of Medicine, 2007
September 12 marked the 50th anniversary of E. Donnall Thomas's initial report of a radical new approach to cancer treatment: radiation and chemotherapy followed by the intravenous infusion of bone marrow. Dr. Frederick Appelbaum writes that Thomas's persistence in the face of criticism and clinical failure ultimately paid off.
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Hematopoietic cell transplantation for mantle cell lymphoma

International Journal of Hematology, 2022
Hematopoietic cell transplantation (HCT) represents a valuable therapeutic option for younger patients with mantle cell lymphoma (MCL). Despite the rarity of this disease, significant research efforts have been undertaken to improve the outcomes, and autologous HCT is currently considered an established treatment for younger patients who respond to ...
Masamitsu Yanada, Kazuhito Yamamoto
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Hematopoietic Cell Transplant

2021
Hematopoietic cell transplantation (HCT) is used to treat a variety of malignant and nonmalignant conditions and carries unique toxicities. This chapter provides an overview of the principles of HCT, focusing on common acute complications that should be recognized by clinicians across all specialties. HCT is also associated with long-term complications
Sherilyn A. Tuazon   +3 more
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Hematopoietic Stem-Cell Transplantation

New England Journal of Medicine, 2006
Hematopoietic stem-cell transplantation, which is used to treat both malignant and nonmalignant conditions, was first conceived more than 50 years ago, but problems associated with transplanting a nonsolid organ and modulating the immune response had to be solved before the procedure could be used clinically.
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Referral to Transplant Center for Hematopoietic Cell Transplantation

Hematology/Oncology Clinics of North America, 2014
Hematopoietic cell transplantation is a complex and highly specialized medical procedure offered by selected centers with the requisite expertise and resources. Timely referral to a transplant center is among the most important determinants of successful outcomes. Patients, providers, and payors consider several factors in selecting a transplant center,
Navneet S, Majhail, Madan, Jagasia
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Radioimmunotherapy for Hematopoietic Cell Transplantation

Immunotherapy, 2013
Radioimmunotherapy (RIT) represents an attractive strategy to deliver radiation selectively to tumor and other target organs while minimizing toxicity to normal tissues. RIT with β-particle-emitting isotopes targeting CD33, CD45 and CD66 can potentially allow intensification of conditioning before hematopoietic cell transplantation (HCT) in leukemia ...
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Hematopoietic Cell Transplantation

DeckerMed Medicine, 2017
Hematopoietic cell transplantation (HCT) can replace abnormal nonmalignant hematopoietic stem cells with cells from a healthy donor, making transplantation a potential cure for a variety of nonmalignant and malignant diseases. This review discusses the indications for HCT, source of stem cells, preparative regimen, engraftment, complications, late ...
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Hematopoietic Stem Cell Transplantation

Clinical Journal of Oncology Nursing, 2004
Nonniekaye Shelburne   +2 more
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Hematopoietic Cell Transplants

2017
This authoritative new book provides a comprehensive overview of diagnostic and therapeutic strategies in hematopoietic cell transplantation, explaining key concepts, successes, controversies and challenges. The authors and editors discuss current and future strategies for major challenges, such as graft-versus-host-disease, including new prophylaxis ...
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Mouse Hematopoietic Stem Cell Transplantation

2013
Hematopoietic stem cells (HSCs) are capable of self-renewal and multi-lineage reconstitution of hematopoiesis in irradiated transplant recipient mice. As such, bone marrow transplantation (BMT) is a major assay commonly used to examine murine HSC activity.
Hui, Cheng, Paulina H, Liang, Tao, Cheng
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