Results 81 to 90 of about 6,010,235 (261)

Kidney Disease Associated with Hematopoietic Stem Cell Transplant

, 2017
Hematopoietic stem cell transplantation in the USA is growing, and stem cell transplant recipients are at risk for both acute and chronic renal injury.
Deirdre Sawinski
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA–peptide tetramers [PDF]

, 2005
Stem cell transplantation is used widely in the management of a range of diseases of the hemopoietic system. Patients are immunosuppressed profoundly in the early posttransplant period, and reactivation of cytomegalovirus (CMV) remains a significant ...
Premini Mahendra, Craddock, Charles., McDonald, D, Billingham, Lucinda, Steward, Colin, Dorothy McDonald, Pourgheysari, Batoul, Eduardo Olavarria, Mahendra, Premini, Assenmacher, Mario., Olavarria, Eduardo, Tauro, Sudhir, Chakraverty, Ronjon., Goldman, John, Cobbold, Mark., Moss, Paul; id_orcid, Steward, Colin., McDonald, Dorothy, Pourgheysari Najafabadi, Batoul, John Goldman, Ronjon Chakraverty, Chakraverty, Ronjon, Crawley, Charles, Colin Steward, Billingham, Lucinda; id_orcid, Craddock, Charles; id_orcid, Assenmacher, Mario, Goldman, J, Pourgheysari, Batoul., Billingham, Lucinda., Tauro, S, Crawley, Charles., Charles Crawley, Osman, H, Batoul Pourgheysari, Naeem Khan, Mario Assenmacher, Osman, Husam, Assenmacher, M, Khan, Naeem, Goldman, John., Craddock, Charles, Mark Cobbold, Steward, C, McDonald, Dorothy., Olavarria, Eduardo., Olavarria, E, Husam Osman, Cobbold, Mark, Crawley, C, Osman, Husam., Mahendra, Premini., Sudhir Tauro, Tauro, Sudhir., Charles Craddock, Moss, Paul A. H., Moss, Paul A H, Khan, Naeem., Lucinda Billingham, Paul A.H. Moss, Moss, Paul A.H.   +60 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Prevention of pure red cell aplasia after major or bidirectional ABO blood group incompatible hematopoietic stem cell transplantation by pretransplant reduction of host anti-donor isoagglutinins

Haematologica, 2009
Background Persistent anti-donor isoagglutinins after major ABO blood group incompatible hematopoietic stem cell transplantation may cause delayed red blood cell engraftment and post-transplant pure red cell aplasia.Design and Methods We investigated the
Georg Stussi, Jörg Halter, Eveline Bucheli, Piero V. Valli, Lutz Seebach, Jürg Gmür, Alois Gratwohl, Urs Schanz, Jakob R. Passweg, Jörg D. Seebach   +9 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Diffuse alveolar hemorrhage is most often fatal and is affected by graft source, conditioning regimen toxicity, and engraftment kinetics

Haematologica, 2018
Diffuse alveolar hemorrhage after hematopoietic stem cell transplantation is a frequently fatal complication with no standard therapy. Although significant changes in supportive and intensive care measures for patients undergoing hematopoietic stem cell ...
Fatma Keklik, Ezzideen Barjes Alrawi, Qing Cao, Nelli Bejanyan, Armin Rashidi, Aleksandr Lazaryan, Patrick Arndt, Erhan H. Dincer, Veronika Bachanova, Erica D. Warlick, Margaret L. MacMillan, Mukta Arora, Jeffrey Miller, Claudio G Brunstein, Daniel J. Weisdorf, Celalettin Ustun   +15 more
doaj   +1 more source

Perforin gene transfer into hematopoietic stem cells improves immune dysregulation in murine models of perforin deficiency [PDF]

, 2015
Defects in perforin lead to the failure of T and NK cell cytotoxicity, hypercytokinemia, and the immune dysregulatory condition known as familial hemophagocytic lymphohistiocytosis (FHL).
Montiel-Equihua, CA, Arumugam, P, Carmo, M, Risma, KA, Blundell, MP, Hontz, AE, Jordan, MB, Gaspar, HB, Malik, P, Thrasher, AJ, Tiwari, S, Schambach, A, Baum, C, Alonso-Ferrero, ME   +13 more
core  

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source