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Hematoporphyrin phototherapy of cancer [PDF]
Hematoporphyrin phototherapy of cancer is a new modality for cancer diagnosis and treatment that is currently undergoing clinical trials worldwide. A variety of tumors have been studied, e.g., breast (mostly recurrent skin), lung, bladder, eye, head and ...
Wile, Alan G, Berns, Michael W
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FLASH‐PDT uses strongly‐absorbing photosensitizers and pulsed lasers to saturate the photosensitizer absorption at ≈1‐cm tissue depths. This allows for the generation of [ROS] above the necrosis threshold level for tumors, while maintaining [ROS] in peritumoral tissues below that threshold, even when the tumor‐to‐peritumoral tissue ratio is as low as 2.
Luis G. Arnaut +3 more
wiley +1 more source
Photodynamic therapy was performed on 25 primary spontaneous tumors in dogs and cats. The animals were injected with 2.5 mg/kg body wt. of tumor localizing fraction of hematoporphyrin derivative and treated 48 h later with laser light at 631 nm.
R. Cheli +4 more
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Hematoporphyrin Photoradiation Therapy for Iris Neovascularization: A Preliminary Report
• Photoradiation therapy is a new technique currently under clinical investigation for the treatment of a variety of solid malignant tumors. The technique involves intravenous (IV) administration of hematoporphyrin derivative, a photosensitizing compound
Tse, David T +3 more
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Photodynamic therapy for extramammary paget’s disease: A retrospective analysis of 15 cases
Background: Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy. Photodynamic therapy (PDT) has shown promise as a treatment option for various skin cancers, including EMPD.
Feng Chen +5 more
doaj +1 more source
Introduction: Photodynamic therapy (PDT) has been investigated as an alternative treatment modality for non-muscle-invasive bladder cancer (NMIBC); however, its clinical application has been limited due to lack of high-quality evidence.
Haitao Li +11 more
doaj +1 more source
Isolated mitochondria have been incubated in the presence of 6 micrograms/ml hematoporphyrin derivative (Photofrin II), and irradiated at lambda = 365 nm.
ATLANTE A +3 more
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By Joseph Mccauley, Chemistry Advisor: Peng Zhang Presentation ID: CC_5 Abstract: Abstract Hematoporphyrin (HP) and hematoporphyrin IX (HPIX) have been successful in experimental usage as leading compounds in nanoparticle ...
Zhang, Peng, Mccauley, Joseph
core
• Hematoporphyrin derivative (HpD) is a photodynamically active dye that is preferentially retained by malignant tissues and initiates a cytotoxic reaction when exposed to red light.
Kersten, Robert C +2 more
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A controlled trial of topical photochemotherapy of plaque-type psoriasis using hematoporphyrin derivative (HPD) in combination with red light (590-700 nm) was performed on 8 patients.
MONFRECOLA, GIUSEPPE +3 more
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