Results 131 to 140 of about 414 (184)
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Photophysics and Photochemistry of Hematoporphyrin, Hematoporphyrin Derivative and Uroporphyrin I
1985The putative action mechanism in photodynamic therapy (PDT) involves serum transport of HPD to tumor tissue, localization and retention of the active constituent, generation of singlet molecular oxygen (Δ) by the action of visible light and the attack of t on the cellular targets.
L I, Grossweiner, A, Blum, G C, Goyal
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Biological Chemistry Hoppe-Seyler, 1991
Rat liver cells incorporate monomeric as well as dimeric hematoporphyrin derivatives. Time-dependent incubation assays gave evidence that monomeric compounds are more efficiently incorporated compared to protoporphyrin dimethyl ester hematoporphyrin ether.
P, Both +4 more
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Rat liver cells incorporate monomeric as well as dimeric hematoporphyrin derivatives. Time-dependent incubation assays gave evidence that monomeric compounds are more efficiently incorporated compared to protoporphyrin dimethyl ester hematoporphyrin ether.
P, Both +4 more
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The effect of hematoporphyrin and light on human platelets. II. Uptake of hematoporphyrin
Journal of Cellular Physiology, 1966AbstractA linear relationship was demonstrated between the reciprocals of the concentration of free hematoporphyrin and the moles of hematoporphyrin taken up by the platelet in the dark. radiated platelets took up more hematoporphyrin than did controls; this increase in uptake was accounted for by the movement of the dye across the damaged membrane of ...
H M, Solomon, P D, Zieve, J R, Krevans
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Hematoporphyrin uptake in atherosclerotic plaques
Neurosurgery, 1988Atherosclerotic plaques were induced in abdominal aortas of rabbits. At 8 weeks, 5 mg of dihematoporphyrin ether (Photofrin II) per kg was injected intravenously followed by sacrifice of the animal, fluorescence microscopy, and quantitative assay of porphyrin in the plaque-containing aortas at 1, 12, 24, 48, and 72 hours.
V, Neave +3 more
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Investigative Radiology, 1990
Manganese (III) hematoporphyrin (MnHP), a new and stable complex, was prepared, and its toxicity and magnetic resonance (MR) imaging properties were evaluated. In tests of acute and subacute toxicity, no deaths resulted from bolus intravenous injections of 13 or 19 mumols/kg of MnHP, but there was a 33% mortality when the dose was 38 mumols/kg ...
P J, Bohdiewicz +5 more
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Manganese (III) hematoporphyrin (MnHP), a new and stable complex, was prepared, and its toxicity and magnetic resonance (MR) imaging properties were evaluated. In tests of acute and subacute toxicity, no deaths resulted from bolus intravenous injections of 13 or 19 mumols/kg of MnHP, but there was a 33% mortality when the dose was 38 mumols/kg ...
P J, Bohdiewicz +5 more
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The Analysis of Hematoporphyrin Derivative
1983When work on photoradiation therapy (PRT) commenced in Adelaide, the stringency of Australian Federal drug regulations made it preferable for us to prepare HPD rather than import the product. It was therefore important that we have an acceptable assay for both HPD solid and HPD clinical1, thereby enabling comparisons between our material and the ...
P A, Cadby +4 more
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Hematoporphyrin and isohematoporphyrin ethers
International Journal of Biochemistry, 1992Abstract 1. 1. The finding that the action catalysed by HClO4 of the alkylating reagent triethylorthoformate upon isohematoporphyrin and hematoporphyrin results in mono-etherification has been considered in relation to the structure of the porphyrin molecule since simple aromatic phenols such as catechol and saligenin react as expected to yield ...
C. Rimington +3 more
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DETERMINANTS OF HEMATOPORPHYRIN‐CATALYZED PHOTOSENSITIZATION
Photochemistry and Photobiology, 1982Abstract Using murine leukemia L1210 cells in culture, determinants of photosensitization by hemato‐porphyrin were examined. Cells incubated for 10 min with a commercial preparation of hematopor‐phyrin rapidly accumulated protoporphyrin and vinyl‐hydroxyethyldeuteroporphyrin present as impurities.
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57Co-Hematoporphyrin Accumulation by Experimental Tumors
Nuklearmedizin, 1976SummaryThe in vivo distribution of 57Co-hematoporphyrin in adenocarcinoma BW10232-bearing mice has been studied. Tumor-bearing and normal animals exhibit similar patterns of radioactivity accumulation. Twenty-four hours after the administration of the radiocompound the ratios tumor to blood and tumor to muscle indicate a potential value of this ...
L J, Anghileri, M, Heidbreder, R, Mathes
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Cell biology of hematoporphyrin derivative (hpd)
Lasers in Surgery and Medicine, 1983AbstractTissue culture cells were treated with hematoporphyrin derivative (HPD) and analyzed for (1) HPD uptake, (2) HPD washout, and (3) fluorescence changes. The absorption peaks were the same for HPD in solution and HPD bound to cells. HPD was taken up by all cell types rapidly within the first 10 hours of exposure, and leveled off by 20 hours of ...
Michael W. Berns +5 more
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