Results 61 to 70 of about 694,144 (304)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Eosinophilic Enteritis in Horses with Motor Neuron Disease
Journal of Veterinary Internal Medicine, 2016 Background Equine motor neuron disease (EMND) is a neuromuscular disorder that affects adult horses. Although EMND has been linked to vitamin E deficiency, its etiopathogenesis is poorly understood.
E. Díez de Castro +6 more
doaj +1 more source
A Model for Investigating Developmental Eye Repair in Xenopus Laevis [PDF]
, 2018 Vertebrate eye development is complex and requires early interactions between neuroectoderm and surface ectoderm during embryogenesis. In the African clawed frog, Xenopus laevis, individual eye tissues such as the retina and lens can undergo regeneration.
Kha, Cindy X. +3 more
core +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Chromatin Texture from Hematoxylin Stained Thyroid Lesions
Analytical Cellular Pathology, 1998 Quantitative aspects of cytology and histology should be considered in diagnostic standardisation processes. The present paper summarises the cytological differences detected in 75 thyroid lesions using a computerized textural analysis.
Olga Ferrer-Roca +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
A case of pyoderma gangrenosum in a dog successfully treated with prednisolone alone [PDF]
, 2015 In this case report, a markedly painful ulcerative dermatitis consistent with pyoderma granulosum is reported in a 2.5-year-old entire female Maltese dog.
Declercq, Jan
core +1 more source
Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study [PDF]
, 2019 BACKGROUND: For virtually every patient with colorectal cancer (CRC), hematoxylin-eosin (HE)-stained tissue slides are available. These images contain quantitative information, which is not routinely used to objectively extract prognostic biomarkers.
Brenner, H. +17 more
core +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Use of Injectable Eugenol for Euthanasia and Anesthesia of American Lobsters (Homarus Americanus) and Similar Species [PDF]
, 2012 Crustaceans are economically and ecologically significant, but current treatment and diagnostic protocols for crustacean health are limited. According to standards given by the American Veterinary Medical Association there are no current methods of ...
Huntsberger, Carlton
core +1 more source