Application of Brownian motion theory to the analysis of membrane channel ionic trajectories calculated by molecular dynamics [PDF]
This paper shows how Brownian motion theory can be used to analyze features of individual ion trajectories in channels as calculated by molecular dynamics, and that its use permits more precise determinations of diffusion coefficients than would ...
Aalfs, Cora M.+6 more
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Collagenous bone matrix-induced endochondral ossification hemopoiesis. [PDF]
Transplantation of collagenous matrix from the rat diaphyseal bone to subcutaneous sites resulted in new bone formation by an endochondral sequence. Functional bone marrow develops within the newly formed ossicle.
Anderson, WA, Reddi, AH
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Nitric oxide, cytochrome c oxidase and myoglobin: Competition and reaction pathways [PDF]
It is relevant to cell physiology that nitric oxide (NO) reacts with both cytochrome oxidase (CcOX) and oxygenated myoglobin (MbO2). In this respect, it has been proposed [Pearce, L.L., et al. (2002) J. Biol. Chem.
Brunori, Maurizio+3 more
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A framework for protein classification [PDF]
It is widely understood that protein functions can be exhaustively described in terms of no single parameter, whether this be amino acid sequence or the three-dimensional structure of the underlying protein molecule. This means that a number of
Kumar, Anand, Smith, Barry
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BioSuper: A web tool for the superimposition of biomolecules and assemblies with rotational symmetry [PDF]
Background Most of the proteins in the Protein Data Bank (PDB) are oligomeric complexes consisting of two or more subunits that associate by rotational or helical symmetries.
Abagyan, Ruben+3 more
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Permeability of rat choriocapillaris to hemeproteins. Restriction of tracers by a fenestrated endothelium. [PDF]
The choriocapillaris is the fenestrated capillary bed in the choroid of the eye and is the major blood supply to the retinal pigment epithelium (RPE) and photoreceptor cells. Bruch's membrane (BM) is a multilaminated basement membrane that separates the choriocapillaris from the RPE. In a previous study (Pino RM, Essner E; Cell Tissue Res 208:21, 1980)
Edward Essner, Richard M. Pino
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Aki associated with macroscopic glomerular hematuria: Clinical and pathophysiologic consequences [PDF]
Hematuria is a common finding in various glomerular diseases. This article reviews the clinical data on glomerular hematuria and kidney injury, as well as the pathophysiology of hematuria-associated renal damage.
Alberto Ortiz+29 more
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Molecular simulations of globins: Exploring the relationship between structure, dynamics and function [PDF]
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32392The discovery in the last two decades of novel members of the globin superfamily has challenged the conventional view about the structure and function of globins.
Arroyo, Pau+10 more
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Engineering cytochrome P450s for enantioselective cyclopropenation of internal alkynes [PDF]
We report a biocatalytic platform of engineered cytochrome P450 enzymes to carry out efficient cyclopropene synthesis via carbene transfer to internal alkynes. Directed evolution of a serine-ligated P450 variant, P411-C10, yielded a lineage of engineered
Arnold, Frances H., Chen, Kai
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Fast ferrous heme-NO oxidation in nitric oxide synthases. [PDF]
International audienceDuring catalysis, the heme in nitric oxide synthase (NOS) binds NO before releasing it to the environment. Oxidation of the NOS ferrous heme-NO complex by O2 is key for catalytic cycling, but the mechanism is unclear.
Santolini, J.+2 more
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