Results 21 to 30 of about 37,295 (215)

A “Mix and Match” in Hemochromatosis—A Case Report and Literature Focus on the Liver

Medicina, 2023
Hemochromatosis is a genetic disorder characterized by increased iron storage in various organs with progressive multisystemic damage. Despite the reports dating back to 1865, the diagnosis of hemochromatosis poses a challenge to clinicians due to its ...
Claudia Oana Cobilinschi, Ioana Săulescu, Simona Caraiola, Andra Florina Nițu, Radu Lucian Dumitru, Ioana Husar-Sburlan, Andra Rodica Bălănescu, Daniela Opriș-Belinski   +7 more
doaj   +1 more source

IRON METABOLISM IN THALASSEMIA AND SICKLE CELL DISEASE

Mediterranean Journal of Hematology and Infectious Diseases, 2009
There are two main mechanisms by which iron overload develops in thalassemias: increased iron absorption due to ineffective erythropoiesis and blood transfusions.
Raffaella Mariani, Paola Trombini, Matteo Pozzi, Alberto Piperno   +3 more
doaj   +1 more source

Iron Metabolism in the Disorders of Heme Biosynthesis

Metabolites, 2022
Given its remarkable property to easily switch between different oxidative states, iron is essential in countless cellular functions which involve redox reactions. At the same time, uncontrolled interactions between iron and its surrounding milieu may be
Andrea Ricci, Giada Di Betto, Elisa Bergamini, Elena Buzzetti, Elena Corradini, Paolo Ventura   +5 more
doaj   +1 more source

Hepcidin and Host Defense against Infectious Diseases. [PDF]

, 2015
Hepcidin is the master regulator of iron homeostasis in vertebrates. The synthesis of hepcidin is induced by systemic iron levels and by inflammatory stimuli.
Ganz, Tomas, Mehrad, Borna, Michels, Kathryn, Nemeth, Elizabeta   +3 more
core   +1 more source

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload [PDF]

, 2011
Iron overload is the hallmark of hereditary hemochromatosis and a complication of iron-loading anemias such as β-thalassemia. Treatment can be burdensome and have significant side effects, and new therapeutic options are needed.
Alan Waring, Bo Qiao, Elizabeta Nemeth, Emilio Ramos, Fujita, Gloria C. Preza, Gualdi, Kearney, Lyskov, Michael A. Peralta, Nemeth, Piotr Ruchala, Porter, Rogelio Pinon, Sham, Shantanu Sharma, Tomas Ganz   +16 more
core   +2 more sources

Diabetes in HFE Hemochromatosis

Journal of Diabetes Research, 2017
Diabetes in whites of European descent with hemochromatosis was first attributed to pancreatic siderosis. Later observations revealed that the pathogenesis of diabetes in HFE hemochromatosis is multifactorial and its clinical manifestations are ...
James C. Barton, Ronald T. Acton
doaj   +1 more source

Safety Aspects of Iron in Food [PDF]

, 2001
During the last decades efforts regarding dietary iron supply focused mostly on the prevention of deficiencies, especially during growth and pregnancy.
Schümann, Klaus
core   +1 more source

Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis [PDF]

, 2018
Osteoporosis is associated with chronic iron overload secondary to hereditary hemochromatosis (HH), but the causative mechanisms are incompletely understood.
Camacho, António, Cancela, M. Leonor, Cohen-Solal, Martine, Hang Korng, Ea, Ostertag, Agnès, Pinto, I. Jorge, Porto, Graça, Simão, Márcio   +7 more
core   +4 more sources

Discrepancy between Serum Ferritin and Liver Iron Concentration in a Patient with Hereditary Hemochromatosis – The Value of T2* MRI

Case Reports in Oncology, 2020
Primary hemochromatosis is an inherited disorder, and the homeostatic iron regulator (HFE) gene C282Y mutation is a common cause of hemochromatosis in Europe. We are reporting a case of a 56-year-old female known to have hemochromatosis with the HFE gene
Mustafa A. Al-Tikrity, Mohamed A. Yassin
doaj   +1 more source

Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plamsa membrane [PDF]

, 2008
Hemochromatosis type 2 gene (HFE2) is highly expressed in skeletal muscle and liver hepatocytes. Its encoded protein, hemojuvelin (HJV), is a co-receptor for the bone morphogenetic proteins 2 and 4 (BMP2 and BMP4) and enhances the BMP-induced hepcidin ...
Altschuler, Babitt, Babitt, Bowman, Camaschella, Chadda, Cole, De Gobbi, Feng, Hammond, Hentze, Huang, Keeling, Krijt, Kuninger, Lin, Lin, Lin, Macia, Matsunaga, Mawdsley, Mayor, Mayor, Meyerhardt, Nemeth, Nichols, Niederkofler, Niederkofler, Oldekamp, Orlandi, Papanikolaou, Park, Pigeon, Roy, Samad, Schmidt, Schmidtmer, Silvestri, Silvestri, Subtil, ten Dijke, Thomas, VanSlyke, Vielmetter, Wang, Wilson, Wilson, Wilson, Yang, Zhang, Zhang, Zhang   +51 more
core   +3 more sources