Results 21 to 30 of about 49,325 (314)

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

The contribution of diet and genotype to iron status in women:a classical twin study [PDF]

, 2013
This is the first published report examining the combined effect of diet and genotype on body iron content using a classical twin study design. The aim of this study was to determine the relative contribution of genetic and environmental factors in ...
Alexander J. Macgregor, AM Minihane, Ana M. Valdes, Ana Paula Arez, Anna A. Wawer, B Benyamin, B Lonnerdal, B Teucher, BA Thompson, CE McLaren, D Gaitán, G Rybo, Geoffrey R. Guile, Jane Skinner, JB Whitfield, JB Whitfield, JD Cook, JN Feder, K Oexle, L Almasy, L Hallberg, LJ Harvey, OM Visscher, R Hurrell, Rachel Hurst, SA Bingham, SJ Thorpe, Susan J. Fairweather-Tait   +27 more
core   +10 more sources

Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy.

Journal of the American Medical Association (JAMA), 2020
Importance Hereditary hemochromatosis is predominantly caused by the HFE p.C282Y homozygous pathogenic variant. Liver carcinoma and mortality risks are increased in individuals with clinically diagnosed hereditary hemochromatosis, but risks are unclear ...
J. Atkins, L. Pilling, Jane A. H. Masoli, Chia-Ling Kuo, J. Shearman, P. Adams, D. Melzer   +6 more
semanticscholar   +1 more source

Neonates with acute liver failure have higher overall mortality but similar posttransplant outcomes as older infants

Liver Transplantation, EarlyView., 2022
Abstract Neonatal acute liver failure (ALF) carries a high mortality rate; however, little data exist on its peritransplant hospital course. This project aimed to identify factors associated with outcomes in neonates with ALF using large multicenter databases.
Swati Antala, Bridget Whitehead, Justin Godown, Matt Hall, Anna Banc‐Husu, Estella M. Alonso, Sarah A. Taylor   +6 more
wiley   +1 more source

Juvenile Hemochromatosis due to a Homozygous Variant in the HJV Gene

Case Reports in Pediatrics, 2022
Hemochromatosis type 2 or juvenile hemochromatosis has an early onset of severe iron overload resulting in organ manifestation such as liver fibrosis, cirrhosis, cardiomyopathy, arthropathy, hypogonadism, diabetes, osteopathic medicine, and thyroid ...
María-Belén Moreno-Risco, Manuel Méndez, María-Isabel Moreno-Carralero, Ana-María López-Moreno, José-Manuel Vagace-Valero, María-José Morán-Jiménez   +5 more
doaj   +1 more source

The Evolution of Iron-Related Comorbidities and Hospitalization in Patients with Hemochromatosis: An Analysis of the Nationwide Inpatient Sample

Blood Science, 2023
Hemochromatosis, either hereditary hemochromatosis (HH) or secondary hemochromatosis, consists of the accumulation of iron in the liver, heart, and other organs. It leads to end-organ damage in a proportion of affected subjects.
Ahmad Abou Yassine, Kira MacDougall, Roula Sasso, Youssef Shammaa, Mira Alsheikh, Mohammad Abureesh, Loai Dahabra, Mohammad Alshami, Stephen Mulrooney   +8 more
doaj   +1 more source

A case of depression with psychotic features associated with hemoglobin Manukau mutation. [PDF]

PCN Rep
Abstract Background It is pertinent to investigate organic possibilities in acute presentation of mental illness. Iron‐deficiency anemia has long been established to cause symptoms of major depressive disorder. The association between depression and hemolytic anemia and hemochromatosis is less understood.
Zhang Z, Greenberg A, Rose L, Jayasooriya T, Thomas N, Das S.   +5 more
europepmc   +2 more sources

A “Mix and Match” in Hemochromatosis—A Case Report and Literature Focus on the Liver

Medicina, 2023
Hemochromatosis is a genetic disorder characterized by increased iron storage in various organs with progressive multisystemic damage. Despite the reports dating back to 1865, the diagnosis of hemochromatosis poses a challenge to clinicians due to its ...
Claudia Oana Cobilinschi, Ioana Săulescu, Simona Caraiola, Andra Florina Nițu, Radu Lucian Dumitru, Ioana Husar-Sburlan, Andra Rodica Bălănescu, Daniela Opriș-Belinski   +7 more
doaj   +1 more source

Idiopathic neonatal haemochromatosis: A case report [PDF]

, 2011
A case of neonatal hemochromatosis is reported in a premature 35-week infant who presented at birth with coffee ground vomiting and gradual appearance of grayish icter and colorless stool.
Alaee, E., Besharat, S., Zahedpasha, Y.
core   +1 more source