Results 101 to 110 of about 153,562 (315)

Tirofiban prevents the effects of SARS-CoV-2 spike protein on macrophage activation and endothelial cell death

Heliyon
SARS-CoV-2 viral-derived particles have been proposed to have a causal role in tissue inflammation. Macrophage is the culprit cell in the pathogenesis of destructive inflammatory response to the SARS-CoV-2 virus. We investigated whether the spike protein
Laura Marrone, Simona Romano, Michele Albanese, Salvatore Giordano, Alberto Morello, Michele Cimmino, Valeria Di Giacomo, Chiara Malasomma, Maria Fiammetta Romano, Nicola Corcione   +9 more
doaj   +1 more source

Baseline Hemodynamics.

, 2015
Values are represented as Mean ± SE and were obtained after addition of hexamethonium. Body weights were recorded before anesthesia [Control: n = 26; TRPA1 -/-: n = 12; TRPV1-/-: n = 12 and TRPAV-/-: n = 12].
Ian N. Bratz (716152), Derek S. Damron (716153), Sayantani Sinha (716150), Pritam Sinharoy (716151)   +3 more
core   +1 more source

Personalized Network‐Guided Neuromodulation Enhances Human Working Memory

Advanced Science, EarlyView.
A personalized neuromodulation framework combining individualized functional brain network targeting with real‐time neural decoding is introduced. Using concurrent TMS–fMRI, participant‐specific stimulation targets and optimal frequencies are identified. Only optimal‐frequency stimulation improves working memory across sessions.
Ahsan Khan, Hongming Li, Camille Blaine, Julie Grier, Ethan Hammett, Almaris Figueroa‐Gonzalez, Sarai Garcia, Romain Duprat, Justin Reber, Joseph Deluisi, Christos Davatzikos, Theodore D. Satterthwaite, Yong Fan, Desmond J. Oathes   +13 more
wiley   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Hemodynamics of the Lower Limbs document

This image reflects a written research document coauthored by William Thornton and W.
Thornton, William E., Hoffler, W.
core  

Natriuretic peptides and cerebral hemodynamics

, 2014
Natriuretic peptides have emerged as important diagnostic and prognostic tools for cardiovascular disease. Plasma measurement of the bioactive peptides as well as precursor-derived fragments is a sensitive tool in assessing heart failure.
Barringer, Filippa, Zois, Nora Elisabeth, Goetze, Jens P, Ashina, Messoud, Guo, Song   +4 more
core   +1 more source

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

Advanced Science, EarlyView.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka, Ana María Pablo‐Sainz‐Ezquerra, Eva Jakljevič, Niki Ktena, Leticia Hosta‐Rigau   +4 more
wiley   +1 more source

Saline inflation–assisted unifocalization for pulmonary atresia with ventricular septal defect and major aortopulmonary collateral arteriesCentral MessagePerspective

JTCVS Techniques
Objectives: Unifocalization for pulmonary atresia with ventricular septal defect and major aortopulmonary collateral arteries remains challenging due to vascular heterogeneity.
Akio Ikai, MD, PhD, Keiichi Hirose, MD, PhD, Mizuhiko Ishigaki, MD, Sung-Hae Kim, MD, Maiko Tachi, MD, Kisaburo Sakamoto, MD, Hiroki Ito, MD   +6 more
doaj   +1 more source

Hemodynamics and Temperature Changes.

, 2014
Basic hemodynamic data and temperature for representative timepoints. No major differences of basic hemodynamics were observed between groups throughout the experiment.* Temperature significantly lower ...
Alexander Lauten (544667), Juergen H. Fischer (544669), Hans R. Figulla (544670), Alexandra Gerhard-Garcia (544668), Frank Suhr (284070), Wilhelm Bloch (45980)   +5 more
core   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source