Results 221 to 230 of about 827,803 (310)

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

Anemia impacts short-term and long-term mortality risk after acute ischemic stroke. [PDF]

Front Stroke
Low CE, Wong HJ, Yau CE, Tan JY, Teo YN, Teo YH, Senff JR, Tack R, Ho AFW, Chan BPL, Yeo LLL, Yeo JYP, Sia CH, Tan BYQ.   +13 more
europepmc   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

High levels of cell-free hemoglobin and iron in cerebral thrombi of pre-Omicron COVID-19 stroke patients: novel drivers of SARS-CoV-2-induced prothrombotic state. [PDF]

Acta Neuropathol
Payá M, Alcahut-Rodríguez C, Barbella-Aponte RA, Hernández-Fernández F, Molina-Nuevo JD, Barroso-García G, Castro-Robles B, López-López S, Arias-Salazar L, Ayo-Martín Ó, García-García J, Yélamos-Sanz B, García-Flores N, Arandilla AG, Moreno-Luna R, Aliena-Valero A, Vielba-Gómez I, Tembl JI, Salom JB, Serrano-Heras G, Segura T.   +20 more
europepmc   +1 more source

Frequent Sweetened Beverage Consumption Is Associated With Accelerated Biological Aging: Evidence From a Population‐Based Study and Gut Microbiota Analysis

Advanced Science, EarlyView.
Frequent sweetened beverage consumption is associated with accelerated biological aging in a large Chinese population. Five gut microbial genera are consistently enriched in both frequent sweetened beverage consumers and individuals with accelerated aging and show significant mediating effects, suggesting a potential microbiota‐related pathway linking ...
Yuwei Shi, Xinmei Li, Yufan Hao, Qiaoyu Wu, Yuji Yu, Siyu Li, Nuo Xu, Yi‐Hsuan Wu, Eunhye Lee, Chi Chang, Emily Hu, Ying Lu, Elizabeth Delzell, Ann W. Hsing, Shankuan Zhu   +14 more
wiley   +1 more source

Renin-angiotensin-aldosterone system inhibition exacerbates anemia in sickle cell disease.

Blood
Eskandari N, Pappano E, Ruiz MA, Mahmud N, Ren G, Ivy Z, Gaitonde S, Gordeuk VR, Gladwin MT, Malik P, Quinn CT, Saraf SL.   +11 more
europepmc   +1 more source

The Diagnostic Utility of Reticulocyte Hemoglobin in Iron Deficiency Anemia and Early Response Following Intravenous Iron Therapy. [PDF]

Cureus
Meena M, Dandasena TP, Goel G, Meena A, Bansal S, Joshi R.   +5 more
europepmc   +1 more source

Artificial Host‐Guest Recognition Directs Glycometabolically Engineered Macrophages to Tumors

Advanced Science, EarlyView.
Glycoengineered supramolecular macrophages (GSAR‐M) are developed using glycometabolic labeling for bioorthogonal host‐guest tumor targeting. This engineering approach unexpectedly enhances macrophage migration, phagocytosis, and pseudopodia formation. Consequently, GSAR‐M demonstrate robust tumor‐targeting specificity, effectively arrest tumor growth,
Zhiqing Yang, Qian Cheng, Ziyi Wang, Jianwen Wei, Qun Guan, Huazhong Yu, Qingwen Zhang, Caixia Yin, Ruibing Wang   +8 more
wiley   +1 more source

Prescribing and dosing patterns of ferric carboxymaltose for iron deficiency anemia: a real-world study from Saudi Arabia. [PDF]

Front Med (Lausanne)
Alzahrani YA, Alkatheeri AA, Alshamrani AB, Alzahrani AM, Alqurashi TMA, Harbi MH, Al-Raddadi R.   +6 more
europepmc   +1 more source

Promoting Electroreduction CO2 to Multi‐Carbon Products by Tailoring the *H Availability With Optimized Interfacial H2O Configuration

Advanced Science, EarlyView.
A catalysis system with adjustable interfacial H2O configuration was conducted by introducing ionomer into Cu. The increasing proportion of K+‐H2O can enhance the dissociation of H2O and improve the generation ability of *H, and the increasing proportion of 4‐HB‐H2O can accelerate the transfer speed of *H to *CO intermediates with the aid of strong ...
Dawei Zhou, Songhu Bi, Jie Zhang, Jinghui Deng, Keyi Xu, Lin Xia   +5 more
wiley   +1 more source