Results 271 to 280 of about 902,120 (353)

Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure‐Based Virtual Screening

open access: yesAdvanced Science, EarlyView.
Pancreatic cancer is a highly aggressive malignancy with limited treatment options. CLK4 regulates alternative splicing, contributing to cancer progression. This study establishes a computational model to identify CLK4 inhibitors, leading to compound 150441 (IC50: 21.4 nm).
Chun‐Lin Yang   +13 more
wiley   +1 more source

Hemoglobin-to-Creatinine Ratio Predicts One-Year Adverse Clinical Outcomes in ST-Elevation Myocardial Infarction: Retrospective and Propensity Score Matched Analysis. [PDF]

open access: yesJ Clin Med
Spadafora L   +21 more
europepmc   +1 more source

Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species

open access: yesAdvanced Science, EarlyView.
This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu   +15 more
wiley   +1 more source

A Rapid Cortical Learning Process Supporting Students’ Knowledge Construction During Real Classroom Teaching

open access: yesAdvanced Science, EarlyView.
There is growing interest in understanding how classroom teaching works, but previous theories and studies leave a gap in the neurocognitive mechanisms involved in real classroom teaching. Here we show that during real classroom teaching, students' middle frontal cortex serves as a hub of a rapid cortical learning process, supporting their knowledge ...
Xiaodan Feng   +6 more
wiley   +1 more source

Hierarchical Assembly of Carbon Dots with Full‐Solar‐Spectrum Absorption for Solar Energy Applications

open access: yesAdvanced Science, EarlyView.
Hierarchical assemblies of carbon dots are constructed, achieving full‐solar‐spectrum absorption, superior photothermal properties, and good hydrophilicity. These assemblies can be in situ prepared on a fabric, which exhibits good performance for applications in solar‐driven interfacial water evaporation and electricity generation.
Lei Li   +9 more
wiley   +1 more source

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