Results 21 to 30 of about 19,761,729 (373)

Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin

open access: yeseLife, 2022
Naturally occurring point mutations in the HBG promoter switch hemoglobin synthesis from defective adult beta-globin to fetal gamma-globin in sickle cell patients with hereditary persistence of fetal hemoglobin (HPFH) and ameliorate the clinical severity.
N. S. Ravi   +24 more
semanticscholar   +1 more source

HEMOGLOBIN-C DISEASE [PDF]

open access: yesArchives of Internal Medicine, 1955
BY THE USE of filter-paper electrophoresis, the hematologist has gained a relatively simple and accurate method of differentiating the various abnormal or atypical hemoglobins.* Thus, we may identify normal hemoglobin (A), sickle hemoglobin (S), the combination of these (S-A) and C-hemoglobin in its homozygous (C-C) and heterozygous (C-A, C-S) states ...
H H, ORVIS, P B, HOLLY, N E, SMITH
openaire   +3 more sources

Sustainable and high-level microbial production of plant hemoglobin in Corynebacterium glutamicum

open access: yesBiotechnology for Biofuels and Bioproducts, 2023
Background Plant hemoglobin shows great potential as a food additive to circumvent the controversy of using animal materials. Microbial fermentation with engineered microorganisms is considered as a promising strategy for sustainable production of ...
Mengmeng Wang   +13 more
doaj   +1 more source

Retinopathy in patient with AC hemoglobinopathy [PDF]

open access: yesRevista Brasileira de Oftalmologia, 2020
Hemoglobin C is the second most frequent Hb variant in Brazil and the world. Hemoglobin C trait is described as a benign and asymptomatic condition. There is little information in the literature about the association of retinal vascular disease and the ...
Aline Guerreiro Aguiar   +3 more
doaj   +1 more source

Acceleration of hemoglobin C crystallization by hemoglobin S [PDF]

open access: yesBlood, 1989
We previously reported that circulating hemoglobin (Hb) CC erythrocytes contain oxygenated HbC crystals with little or no HbF and that HbF inhibits in vitro crystallization of HbC. We now report that HbS accelerates in vitro crystallization of HbC. Crystals were formed in 1.8 mol/L potassium phosphate buffer, pH 7.4, at 30 degrees C and were counted in
M J, Lin, R L, Nagel, R E, Hirsch
openaire   +2 more sources

Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants.

open access: yesNew England Journal of Medicine, 2020
BACKGROUND Limited data suggest that higher hemoglobin thresholds for red-cell transfusions may reduce the risk of cognitive delay among extremely-low-birth-weight infants with anemia.
H. Kirpalani   +33 more
semanticscholar   +1 more source

The relationship between high-density lipoprotein cholesterol (HDL-C) and glycosylated hemoglobin in diabetic patients aged 20 or above: a cross-sectional study

open access: yesBMC Endocrine Disorders, 2021
Aim The incidence rate of diabetes is increasing year by year, seriously threatening human health. As a predictor of glycemic control, glycated hemoglobin is reported to be related to various complications and prognoses of diabetes.
Rui Huang, Li Yan, Yuhua Lei
doaj   +1 more source

Paper-based microchip electrophoresis for point-of-care hemoglobin testing.

open access: yesIn Analysis, 2020
Nearly 7% of the world's population live with a hemoglobin variant. Hemoglobins S, C, and E are the most common and significant hemoglobin variants worldwide.
M. N. Hasan   +28 more
semanticscholar   +1 more source

Comparative Study on Electrophoretic Hemoglobin Types and Serum Protein Fractions, Some Biochemical and Hormones Parameters Changes During Transition Period in Iraqi Cows [PDF]

open access: yesBasrah Journal of Veterinary Research, 1970
       This study was conducted to determine the type of blood hemoglobin blood and its effect on biochemical parameters, which include the lipid profile and hormones of local cows in Basrah  province  by obtaining
Enas S. yahya, Rashad F. Ghadhban
doaj   +1 more source

Hemoglobin concentration is associated with the incidence of metabolic syndrome

open access: yesBMC Endocrine Disorders, 2021
Background An association between hemoglobin and metabolic syndrome (MetS) has been reported. However, the relationships between hemoglobin and individual MetS components remain unclear.
Sunyue He   +5 more
doaj   +1 more source

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