Results 321 to 330 of about 19,761,729 (373)

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

Lower hemoglobin levels may increase the risk of diabetic retinopathy in patients with type 2 diabetes mellitus. [PDF]

BMC Endocr Disord
Mao K, Liu R, Jiang P, Cai W, Lin Y, Chen F, Wang L, Li D.   +7 more
europepmc   +1 more source

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Development of a novel method to evaluate gingivitis in children by combining rapid saliva test systems. [PDF]

Sci Rep
Iwamoto Y, Mitsuhata C, Ikeda S, Ito Y, Hamaguchi S, Tabata E, Tsuge Y, Kaneki A, Ogawa M, Nishimura T, Kametani M, Kusaka S, Asao Y, Akitomo T, Kozai K, Nomura R.   +15 more
europepmc   +1 more source

Hemoglobin as an oxygen gasoreceptor. [PDF]

Acta Biochim Pol
Anbalagan S.
europepmc   +1 more source

Association of hemoglobin level trajectories with clinical outcomes in patients with sepsis or shock: a retrospective observational study. [PDF]

BMC Infect Dis
Huang J, Zou D, Wang Q, Liu Y, Zhang K, Liu S, Huang S.   +6 more
europepmc   +1 more source

Lower Hemoglobin Following Adult Spine Deformity Surgery Leads to Longer Hospital Length of Stay. [PDF]

Cureus
Mathew J, Gum J, Glassman SD, Djurasovic M, Brown ME, Mahoney C, Daniels C, Carreon L.   +7 more
europepmc   +1 more source