Results 41 to 50 of about 14,684 (152)

Iron, arginine, and redox metabolism in peripheral blood mononuclear cells distinguishes sickle cell disease and pulmonary hypertension

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract Pulmonary hypertension (PH) is a severe vascular complication of sickle cell disease (SCD); yet, not all patients with SCD develop PH, and PH also arises independently. This duality underscores the need to understand their intersecting biology.
Francesca I. Cendali, Christina Lisk, Amy Argabright, Monika Dzieciatkowska, Nishant K. Rana, Delaney Swindle, Daniel Stephenson, Julie McAfee, Natalie Westover, Melissa Lucero, Aneta Gandjeva, Kurt Stenmark, Rubin Tuder, Brian B. Graham, Tim Lahm, Vijaya Karoor, Gemlyn George, Kathryn Hassel, Rachelle Nuss, Pavel Davizon‐Castillio, Paul W. Buehler, Angelo D'Alessandro, David C. Irwin   +22 more
wiley   +1 more source

Cannabis and Alcohol Use and Their Effects on Hematological and Biochemical Parameters: Evidence From the Accra Psychiatric Hospital, Ghana

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Substance use, particularly cannabis and alcohol consumption, presents a growing public health challenge in Ghana, with significant implications for both mental and physical health. While the adverse psychological effects of these substances have been extensively studied, their biochemical impact remains inadequately explored ...
Felix Abekah Botchway, Prince Agyemang, Fati Sidi Yahaya, Emmanuel Baah‐Sackey, Christiana Anim, Emmanuel Abindau, Cecilia Elorm Lekpor   +6 more
wiley   +1 more source

Prevalence and Determinants of Anemia and Iron Deficiency Anemia Among Patients With Diabetes Mellitus in Cameroon: An Analytical Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Anemia is a significant complication that worsens disease outcomes. They can be multifactorial, including micronutrient deficiencies and iron deficiencies. This study aimed to determine the prevalence and associated factors of anemia and iron deficiency anemia (IDA) among diabetic patients in Cameroon. Methods An analytical
Leonard Tedong, Romaric Tuono De Manfouo, Melisa Mene Djeukamgang, Marius Mbiandjeu Tchoumke, Pascal Blaise Well A Well A Koul, Maï‐Pamela Tumchou Mekieje, Josué Louokdom Simo, Pascal Dieudonne Chuisseu Djamen   +7 more
wiley   +1 more source

Assessing Liver and Iron Markers in Steady State Pediatric SCD Patients to Ascertain the Hepatic Consequences of Hemotransfusion: A Case‐Control Study in Ghana

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Between 200,000 and 300,000 children with sickle cell disease (SCD) are born in Africa every year, with 75%–80% of these children living in sub‐Saharan Africa. In newborns with SCD, significant iron accumulations may develop because of their increased risk of requiring multiple blood transfusions. This study aimed to assess
John Agyemang Sah, Stephen Twumasi, Allwell Adofo Ayirebi, Benedict Sackey, Enoch Odame Anto, Richard Vikpebah Duneeh, Ebenezer Senu, Veronica Barnor, David Boakye, Daniel Nii Martey Antonio, Wina Ivy Ofori Boadu   +10 more
wiley   +1 more source

Prevalence and Risk Factors of Anemia in Pregnant Women Attending Antenatal Clinic at a Medical Center in Accra, Ghana: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Anemia during pregnancy remains a major cause of maternal and infant morbidity in Ghana and has broader socioeconomic implications. Its persistence despite existing interventions indicates that factors such as education, occupation, and nutrition require closer evaluation.
Gifty Amewudah, Frank Twum Aboagye, Frank Quarshie, Martin Owusu Asante, Benjamin Ansah‐Agyei, Joseph Otchere, Philip Narteh Gorleku, Maurice Ofoe Gorleku, Margaret Atuahene, Abena Mantebea Ateko, Daniel Eshun   +10 more
wiley   +1 more source

Signal Peptide Engineering and Codon Optimization to Enhance α‐Gal A Activity for rAAV Gene Therapy of Fabry Disease

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Fabry disease is an X‐linked lysosomal storage disorder caused by mutations in the GLA gene, leading to deficient α‐galactosidase A (α‐Gal A) activity and pathological accumulation of globotriaosylceramide (Gb3) and globotriaosylsphingosine (Lyso‐Gb3) in various organs.
Siwu He, Li Yang, Ke Wan, Zhaoyue Zheng, Mi Leng, Chunmei Gan, Yu Liu, Lin Xiao, Jingya Ye, Zhian Chen, Jiao Zhou, C. Alexander Valencia, Aliah Abuammah, Hoi Yee Chow, Biao Dong, Yucheng Chen   +15 more
wiley   +1 more source

Clinical Characteristics and Gene Mutations of Hereditary Spherocytosis in 59 Chinese Children

Molecular Genetics &Genomic Medicine, Volume 14, Issue 3, March 2026.
Summary of the causative genes' spectrum of 59 Chinese HS Children patients. The schematic diagram of ankyrin, β‐spectrin, α‐spectrin, and band three protein domains with ANK1, SPTB, SPTA1, and SLC4A1 mutations. Distribution of mutations in the exons of ANK1 and SPTB genes.
Yuzhuopu Li, Yang Wang, Tao Liu, Li Xiao, Lan Huang, Yongjie Zhang, Yan Xiang, Jie Yu   +7 more
wiley   +1 more source

Basiliximab in the Prophylaxis of aGVHD for Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients With Thalassemia Major: A Prospective, Multicenter, Open‐Label, Randomized Controlled Study

American Journal of Hematology, Volume 101, Issue 3, Page 628-632, March 2026.
Zhenbin Wei, Rongrong Liu, Lingling Shi, Qiaochuan Li, Lianjin Liu, Baoshi Zheng, Chunjie Qin, Hong Chen, Guyun Wang, Meiqing Wu, Gaohui Yang, Ruolin Li, Zhaoping Gan, Qi Zhou, Jing Fan, Xuemei Zhou, Yinghua Chen, Zhiyu Zeng, Zhongming Zhang, Yongrong Lai   +19 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, Volume 22, Issue 16, 17 March 2026.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Landscapes of HLA Mismatching in Contemporary Unrelated Haematopoietic Cell Transplantation

HLA, Volume 107, Issue 3, March 2026.
ABSTRACT Haematopoietic cell transplantation (HCT) with HLA‐mismatched unrelated donors (MMUD) offers access to curative therapy for patients lacking well‐matched donors. Accumulating evidence suggests that functional matching among allele‐mismatched pairs can significantly influence patient outcomes.
Esteban Arrieta‐Bolaños, Edouard F. Bonneville, Pietro Crivello, Tobias Gedde‐Dahl, Régis Peffault de Latour, Urpu Salmenniemi, Nicolaus Kröger, Ibrahim Yakoub‐Agha, Marco Zecca, Goda Choi, Charles Crawley, Eleni Tholouli, Valérie Dubois, Juha Peräsaari, Lotte Wieten, Steven G. E. Marsh, Mats Bengtsson, Jorinde D. Hoogenboom, Jürgen Kuball, Florent Malard, Annalisa Ruggeri, Katharina Fleischhauer   +21 more
wiley   +1 more source