Results 51 to 60 of about 23,191 (234)

Medication Utilization Among Children With Sickle Cell Disease in the United States

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Objective The medication management of children with sickle cell disease (SCD), especially since the release of the 2014 National Heart, Lung, and Blood Institute (NHLBI) SCD treatment guidelines, is not well described in the published literature.
Abiodun John Ologunowa, Kelly L. Matson, Jung Eun Lee, Meghan McCormick, Mary L. Greaney, Aisling R. Caffrey   +5 more
wiley   +1 more source

Prenatal Exome Sequencing Identifies Dual Maternal‐Fetal Diagnosis of HbF Mission Bay, a Novel HBG2 Variant Associated With Methemoglobinemia, Hypoxia and Hemolytic Anemia

Prenatal Diagnosis, EarlyView.
ABSTRACT Prenatal exome sequencing (ES) can establish rare genetic diagnoses in a fetus but may also lead to occult genetic diagnosis in a biological parent. We present a case of dual fetal and maternal diagnosis by prenatal ES, in a fetus with unexplained anemia and in a pregnant patient with sickle cell disease (SCD) and recurrent unexplained hypoxia.
Matthew A. Shear, Billie Lianoglou, Ugur Hodoglugil, W. Patrick Devine, Ashutosh Lal, Juan Gonzalez, Teresa N. Sparks   +6 more
wiley   +1 more source

Amniocentesis and Risk of Fetal Loss in Dichorionic‐Diamniotic Twin Pregnancy: A Case‐Control Study

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective There is a paucity of data regarding the risk of fetal loss due to invasive prenatal diagnosis in twins. The aim of the present study is to assess the rate of amniocentesis‐related fetal loss in uncomplicated dichorionic‐diamniotic (DCDA) twin pregnancies. Methods Retrospective observational case‐control study.
Sofia Roero, Agata Ingala, Silvana Arduino, Carlotta Bossotti, Simona Bastonero, Francesca Maria Comoglio, Ilaria Dusini, Annasilvia Pertusio, Roberto Scali, Simona Sdei, Alberto Revelli, Andrea Sciarrone   +11 more
wiley   +1 more source

Haploidentical HSCT for hemoglobinopathies: improved outcomes with TCRαβ+/CD19+-depleted grafts.

Blood Advances, 2018
We examined outcomes of haploidentical hematopoietic cell transplantation (haplo-HCT) using T-cell receptor αβ+ (TCRαβ+)/CD19+-depleted grafts (TCR group, 14 patients) in children with hemoglobinopathies.
J. Gaziev, A. Isgrò, P. Sodani, K. Paciaroni, Gioia De Angelis, M. Marziali, M. Ribersani, C. Alfieri, A. Lanti, T. Galluccio, G. Adorno, M. Andreani   +11 more
semanticscholar   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Comparative Study of Red Blood Cell Parameters in Different Hemoglobinopathies Diagnosed by HPLC at a Tertiary Care Hospital, Rajkot, Gujarat

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Background: Inherited disorders of hemoglobin (hemoglobinopathies) are the most common genetic disorders in the world with 7% prevalence. Thalassemia and sickle cell anemia are the most prevalent hemoglobinopathies in India.
Khushbu K. Tilva, Deepa Jethwani, Payal Shah, Gauravi A. Dhruva   +3 more
doaj   +1 more source

Population Screening for Hemoglobinopathies.

Annual review of genomics and human genetics (Print), 2018
Hemoglobinopathies are the most common single-gene disorders in the world. Their prevalence is predicted to increase in the future, and low-income hemoglobinopathy-endemic regions need to manage most of the world's affected persons.
H. Goonasekera, C. Paththinige, C. Paththinige, Vajira H. W. Dissanayake   +3 more
semanticscholar   +1 more source

A demographic prevalence of β Thalassemia carrier and other hemoglobinopathies in adolescent of Tharu population

Journal of Family Medicine and Primary Care, 2020
Background and Aims: Hemoglobinopathies and thalassemias are the commonest single gene disorders in India. In Terai region of India, Hemoglobinopathies and thalassemias are the most common in the Tharu community.
Nitu Nigam, R. Kushwaha, Geeta Yadav, Prithvi Singh, N. Gupta, Bhupendra Singh, Monica Agrawal, Pooran Chand, Shailedra Saxena, M. Bhatt   +9 more
semanticscholar   +1 more source

Provision of peri‐operative patient blood management strategies in the UK: a national survey of practice

Anaesthesia, EarlyView.
Summary Introduction In UK hospitals, it is unclear how organisational structures are arranged to support effective implementation of peri‐operative blood management practice strategies. The aim of this study was to conduct a national survey of organisations to describe local practices of peri‐operative patient blood management and infrastructure ...
Samantha R. Warnakulasuriya, Kathleen Wolff, Simon J. Stanworth, on behalf of the Research and Audit Federation of Trainees group and the NIHR BTRU in Data Driven Transfusion Practice Collaborators, Hayley Evans, Alwyn Kotze, Mike Murphy, Antony Palmer, Akshay Shah, Noemie Roy, Martha Belete, William Spencer, Katie Preston, Rebecca Hawes, Reeanne Jones, Murray Williams, Ahmed Ibrahim, Aimi Lara Emilie Jeanes, Akshay Shah, Alan Race, Alexander Bell, Alison Chalmers, Alison Evans, Amarjeet Patil, Amelia Van Manen, Amy Thomas, Anandh Balu, Annette Haines, Annie Smith, Apurva Patil, Ashish Gandhi, Ashley McIlroy, Asya Veloso Costa, Barrie Philip Robertson, Beatrice Meilak, Ben Chandler, Bhavesh Gohil, Carlos Eduardo Abrunhosa de Mattos, Charlotte Katie Morris, Chintan Vora, Chiu Lee, Chris Oscier, Christopher Dixon, Ciara O'Brien, Clare Dallimore, Clare Quaterman, Colette Keenan, Cristian Lasai, Dale Seddon, Daniel Haslam, Darren Caldow, David Perry, Declan Love, Dina Bowey, Earlene Armstrong, Elizabeth Ribey, Emily Yeung, Emma Jacobs, Farzana Begum, Freya Brownlow, Gautam Dhananjay Modak, Gemma Talling, Georgia Monantera, Gomathy Kandasamy, Hannah Houston, Hannah Kennedy, Hannah Louise Headon, Helen Tyler, Henry Sergeant, Ismaa Aslam, Jade Loughran, Jake Melhuish, James Kirkland, James Morris, Jane Doherty, Jennifer Brooke, Jennifer Phillips, Jessica Irwin, Joel Prescott, Jordan McVey, Josephine Barnsley, Ka Po Tam, Katherine Saunders, Kim Rhodes, Krupa Basavaraj, Kush Amin, Laura Carter, Laura Field, Laura Fulton, Laura Scott, Leon Cohen, Louis Murphy, Madeleine Edwards, Madhavi Gudipati, Magde Albarade, Mai Wakatsuki, Manaf Al‐Bayati, Mark Dorrance, Marta Malaj, Matt Bridge, Matthew Peacock, Maya Sussman, Michael Jarvis, Michael Olivier, Mohamed Elbahnasy, Mohammad Sharif, Molly Janowski, Nadeeshya Dulanjalee Welikala, Naomi R C Adey, Nicola Coverdale, Noorunisa Suhail, Oliver Dare, Orlagh McNally, Paul Young, Pei Shan Lim, Peter Sandbach, Philippa Horne, Prathiban Kumar, Puja Chhaniyara, Putri Rimba, Rabia Ghani, Rashmi Rebello, Rebecca Allott, Rebecca Vickers, Richard Timoney, Rishi Naik, Robert Davidson, Robert Palin, Rosanna Seatter, Rotimi Latinwo, Ruchi Maniar, Ryad Sammy Chebbout, Sabba Aziz, Samah Alimam, Samuel Lichfield, Sharon Ramirez, Shashiharen Gnanapandithen, Shashikant Yegnaram, Shriyam Patel, Simon Beecroft, Sioned Elin Davies, Stephanie Worrall, Stuart Cleland, Subhadra Devi Balakrishnan, Suji Pararajasingam, Sumithre Gunathilake, Svetlana Kulikouskaya, Tajwinder Singh Sandhar, Tina Vaz, Toby Reynolds, Tom Kingston, Val Luoma, William Booth, Xiaosu Jiang, Zaid Saghir Ahmed, Zwesty Viera   +155 more
wiley   +1 more source

A systematic review on the determinants of long‐term kidney sequelae after hypertensive diseases of pregnancy

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
This systematic review aimed to evaluate the risk of chronic kidney disease (CKD) after preeclampsia and the determinants of these sequelae. Five authors found a more significant risk of kidney disease after PE, with a risk ranging from two to three times higher.
Marie Haudiquet, Marion D'Incau, Vincent Letouzey, Olivier Moranne   +3 more
wiley   +1 more source