Results 41 to 50 of about 9,398 (186)

The clinical impact of MTHFR polymorphism on the vascular complications of sickle cell disease [PDF]

, 2006
Sickle cell disease (SCD) is one of the most common inherited diseases in the world and the patients present notorious clinical heterogeneity. It is known that patients with SCD present activation of the blood coagulation and fibrinolytic systems ...
Beltrão, A.c.s., Figueiredo, Maria Stella, Gil, I.c.p., Lourenco, Dayse Maria, Moreira Neto, F., Morelli, V.m., Noguti, Maria Aparecida Eiko   +6 more
core   +3 more sources

Understanding erythroid physiology and pathology in humanized mice: A closer look

British Journal of Haematology, Volume 206, Issue 5, Page 1272-1284, May 2025.
Erythropoiesis, the formation of red blood cells (RBCs) from haematopoietic stem cells (HSCs), is vital for understanding conditions like anaemia and haemoglobinopathies. However, studying this process in vivo is challenging due to the lack of accurate models.
Lu Lu, Chenfei Liu, Lezong Chen, Xumiao Zhang, Yinglin Su, Zhenzhen Chou, Yang Liang, Yuanbin Song   +7 more
wiley   +1 more source

Is Hemoglobin Variant Analysis Helpful in the Diagnostic Work-up of Patients Revealing Microcytic Erythrocytosis on Complete Blood Count? [PDF]

, 2015
Introduction: Microcytic erythrocytosis is an abnormal CBC (complete blood count) finding that is under-recognized, poorly understood, and consequently under-utilized in patient care. It is characterized by decreased MCV and increased RBC count.
Dulau-Florea, Alina, Gong, MD, Jerald Z., Gulati, Ph.D, Gene, Joneja, MD, Upasana   +3 more
core   +1 more source

Real‐world insights from a cohort of approximately 2000 individuals who were analysed using a freely available next‐generation sequencing anaemia screening programme

British Journal of Haematology, EarlyView.
Data from a large cohort of individuals referred for NGS testing evaluate the utility of next‐generation sequencing in clinical practice for diagnosing hereditary haemolytic anaemias.
Jorune Balciuniene, Saliha Yilmaz, Satheesh Chonat, Rachael F. Grace, Gerald A. Soff, Yaddanapudi Ravindranath, Bertil Glader, Paola Bianchi, Bryan McGee, Archana M. Agarwal, Geetha Puthenveetil   +10 more
wiley   +1 more source

A validated measure of adherence to antibiotic prophylaxis in children with sickle cell disease [PDF]

, 2016
BACKGROUND: Antibiotic prophylaxis is a mainstay in sickle cell disease management. However, adherence is estimated at only 66%. This study aimed to develop and validate a Sickle Cell Antibiotic Adherence Level Evaluation (SCAALE) to promote systematic ...
Bloom, Ellen M., Duncan, Natalie A., Hampton, Kisha C., Kronenberger, William G., Rampersad, Angeli G., Roberson, Christopher P., Shapiro, Amy D.   +6 more
core   +2 more sources

How low can we go? Comparison of liberal and restrictive red cell transfusion thresholds in paediatric allogeneic haematopoietic stem cell transplantation: A randomized multicentre feasibility trial

British Journal of Haematology, EarlyView.
Optimal red blood cell transfusion thresholds for children with bone marrow failure are uncertain. Children may be able to safely tolerate lower haemoglobin thresholds, thereby reducing transfusions, which have risks. This study in paediatric allogeneic haematopoietic stem cell transplant aimed to assess feasibility of recruitment and protocol ...
H. V. New, E. Sanderson, V. Hopkins, H. Thomas, A. Gassas, M. Adams, B. Gibson, K. Patrick, R. Wynn, L. Hoole, H. Smethurst, M. Lobo‐Clarke, L. Smith, A. Mora, S. J. Stanworth   +14 more
wiley   +1 more source

The wider perspective: Barriers and recommendations for transfusion support for patients with sickle cell disease in low‐ and middle‐income countries

British Journal of Haematology, EarlyView.
Globally, sickle cell disease (SCD) is the most common inherited haemoglobinopathy. The highest burden of SCD is encountered in low‐ and middle‐income countries (LMICs), most of which lack the resources to contend with the disease. Blood transfusion remains central to the emergent treatment and prevention of complications of SCD.
Jeremy W. Jacobs, Luiz Amorim, France Pirenne, Claude Tayou, Ijele Adimora, Lydia H. Pecker, Aaron A. R. Tobian, Jeannie Callum, Julie Makani, Mark T. Gladwin, Meghan Delaney, Darrell J. Triulzi, Isaac Odame, Evan M. Bloch   +13 more
wiley   +1 more source

Sickle cell disease status among school adolescents and their tribal community in South Gujarat [PDF]

, 2009
Objectives: to create awareness, to screen samples of school adolescents and then to reach their community through them by doing surveillance for sickle cell disease. Design: Field based cross-sectional study. Settings: St Xavier`s high school and Vanraj
Chudasama, Rajesh K, Godara, Naresh R, Srivastava, Ratan K, Vasava, Bipin   +3 more
core   +1 more source

Underlying disease is the main risk factor in post‐splenectomy complication risk: Data from a national database

British Journal of Haematology, EarlyView.
The association between underlying haematological disease, age at splenectomy and post‐splenectomy complications was explored among 1348 splenectomized patients, followed in 53 clinical centres with a median follow‐up time of 13 years and affected by transfusion‐dependent thalassaemia (TDT), non‐transfusion‐dependent thalassaemia (NTDT), sickle cell ...
Maddalena Casale, Raffaella Colombatti, Manuela Balocco, Paola Corti, Susanna Barella, Giovanna Graziadei, Loredana Farinasso, Tommaso Mina, Simone Cesaro, Tommaso Casini, Fiorina Giona, Saverio Ladogana, Pellegrina Pugliese, Lucia Dora Notarangelo, Antonella Sau, Simone Ferrero, Giovanni Palazzi, Giovanna Russo, Ilaria Lazzareschi, Marilena Serra, Saveria Campisi, Gianluca Boscarol, Elena Facchini, Carlo Baronci, Maria Caterina Putti, Domenico Roberti, Marzia Manilia, Antonio Ivan Lazzarino, Gian Luca Forni, Silverio Perrotta, on behalf of the Italian Network of Asplenia, Piero Farruggia, Francesca Fioredda, Paola Giordano, Federico Verzegnassi, Maria Luisa Casciana, Assunta Tornesello, Ilaria Capolsini, Paolo Grotto, Paola Maria Grazia Sanna, Luciana Rigoli, Rosanna Di Concilio, Flavia Rivellini, Annamaria Pansanisi, Gloria Colarusso   +44 more
wiley   +1 more source

Coexisting Cardiac and Hematologic Disorders. [PDF]

, 2016
Patients with concomitant cardiac and hematologic disorders presenting for noncardiac surgery are challenging. Anemic patients with cardiac disease should be approached in a methodical fashion.
Goldhammer, Jordan E., Kohl, Benjamin A.
core   +3 more sources