Results 81 to 90 of about 4,553 (296)
Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy
Advanced Science, EarlyView.A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou +13 morewiley +1 more sourceTriagem neonatal para hemoglobinopatias: um estudo piloto em Porto Alegre, Rio Grande do Sul, Brasil Neonatal screening for hemoglobinopathies: a pilot study in Porto Alegre, Rio Grande do Sul, Brazil
Cadernos de Saúde Pública, 2002 Este estudo, tem como o objetivo determinar a freqüência das hemoglobinopatias em neonatos, que realizaram a coleta para o Teste de Triagem Neonatal para Distúrbios Metabólicos no Hospital de Clínicas de Porto Alegre.Liane Esteves Daudt, Débora Zechmaister, Liliana Portal, Eurico Camargo Neto, Lúcia Mariano da Rocha Silla, Roberto Giugliani +5 moredoaj +1 more sourceTargeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis
Advanced Science, EarlyView.Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju +8 morewiley +1 more sourceBeta globin gene cluster haplotypes of abnormal hemoglobins observed in Turkey
, 2007 Since the first observation of hemoglobin S (Hb S) in Turkey by Aksoy, the number of hemoglobin variants reported was increased. Beta globin gene cluster haplotypes are being used to determine the origin of the mutations under interest.Bayram, J., Atalay, Ömer Erol, Öztürk, Onur, Koyuncu, H., Atalay, Ayfer., Özkan, Anzel, Aksoy, Kıymet, Köseler, Aylin, Demirtepe, Sanem +8 morecore Common Variants at 10 Genomic Loci Influence Hemoglobin A(1C) Levels via Glycemic and Nonglycemic Pathways [PDF]
, 2010 Glycated hemoglobin (HbA₁(c)), used to monitor and diagnose diabetes, is influenced by average glycemia over a 2- to 3-month period. Genetic factors affecting expression, turnover, and abnormal glycation of hemoglobin could also be associated with ...Döring, Angela, Stewart, A.F.R., Seedorf, Udo, Boehnke, M., Fox, Caroline S., Rocheleau, Ghislain, Wichmann HE, Samani, NJ, Uda, M., Elosua, R., Sanna, Serena, Boerwinkle, E., Wheeler, E., Sandhu, MS, Boehnke, M, Groop, L, Bornstein SR, Mangino, M., Sanna, S, Cao, A, Groop L, Jackson, Anne U., Wichmann, H.-E., Willenborg, C., Kuusisto, J, Zabena, C, Bonnycastle, LL, Sanna, S., Peltonen, L, Kooner, Jaspal, Lathrop, Mark, Kao, W.H.L., Hunter-Merril, R., Hottenga, J.-J., Langenberg, C, Lyssenko, V., Goel, A, Jackson AU, Devaney, J. M., Heath, S, Krohn, K., Groop, L., Heeney, M.M., Wallaschofski, H, Tönjes, Anke, Cao, A., Mälarstig, A, Ripatti S, Barroso, Inês, Burnett-Miller, M.S., Heeney, Matthew M, Cao A, Boerwinkle, Eric, Burnett-Miller, MS, Stefansson, K, Kong, Augustine, Oexle, Konrad, Altshuler, D., Boerwinkle, E, Wild, SH, Arking, D., Strawbridge, Rona, Roberts, Robert, Kao, W.H. Linda, Bonnycastle LL, Manjinder S. Sandhu, Gieger, C, Kuusisto J, Procardis Consortium Group, Meisinger, Christa, Li, Mingyao, Surakka, Ida, Wichmann, H-Erich, Willenborg, Christina, Goel, Anuj, Perola M, Kong, A., Böhm B, Wright, Alan F, Voight, Benjamin F., Dupuis J, Franzosi, Maria Grazia, Böttcher, Y., de Geus, Eco J C, Radke D, Dei, Mariano, Graessler, J., Meigs, JB, Stewart, Alexandre F.R., Homuth, G, Roden, M, Prokopenko I, Martínez-Larrad, MT, Campbell, Harry; id_orcid, März, Winfried, Strachan, David P., Kooner, J., Strawbridge, R, Salomaa, Veikko, Forouhi, N, Collins, Francis S, Gieger C, Clark, Robert, Laakso, M, Jula A, Stolerman, Elliot, Eleanor Wheeler, Kleber, M, ?, ?, Salomaa, V, Zhao, Jing Hua, Steinthorsdottir, V, Hall, A., Sanna, Serena; id_orcid, Böhm, B, Perola, M, Nauck, Matthias, Serrano-Ríos, Manuel, de Geus, EJ, McCarthy, MI, Knouff, C.W., Siscovick, David, Boehm, Bernhard, Sladek, R, Illig T, Saxena, R, Reilly, Muredach P., Greinacher, A, Lecoeur, C., Vitart, Veronique, Herder, C, Winkelmann, J., Magnusson, PK, Waterworth, Dawn M., Uda, Manuela, Prokopenko, Inga, Usala, G, Schunkert, H, Hadley, D., Radke, D, Arking, Dan, Loos, Ruth J.F., Procardis Consortium (), Dupuis, Josée, Graessler, J, Abecasis, G.R., Kleber, Marcus, Radke, Dörte, Sladek, Robert, Oexle, K, Abecasis, Gonçalo, Wareham, N.J., Barnes, Daniel, Martínez-Larrad, María Teresa, Mangino, M, Radke, D., Silveira, Angela, Böhm, Bernhard, Claudia Langenberg, Franzosi, MG, Heath, S., Goel, A., Erdmann, Jeanette, Elliot Stolerman, Seedorf, U, Fox, CS, Wright, B., Böttcher, Yvonne, Josée Dupuis, Kovacs, P., Pedersen, Nancy L., Illig, T., Laakso, M., Lyssenko, V, Herder, C., Ferrucci, L, Bonnefond, A., Kuusisto, J., Collins, F.S., Knouff, Christopher W., Jackson, A.U., McArdle, Wendy L., Laakso M, Voight BF, Bornstein, S.R., Dupuis, J, Greinacher, Andreas, Mägi, R, Bornstein, SR, Ricketts, S. L., Völzke, H, McPherson, R, Reilly, MP, Deloukas P, Elosua, R, Perola, Markus, Nathan, David M., Deloukas, P., Egan, JM, Köttgen, Anna, Wallaschofski, Henri, Waterworth, DM, Rocheleau, G, de Geus, Eco J.C., Erdmann, J, Wright, AF, Muredach P. Reilly, Rathmann, W, Sandhu MS, Wareham, NJ, Wright, Alan F., Matthew M. Heeney, Peltonen L, Jula, A, Teumer, A, Melander, O, Meigs, James B., Thorsteinsdottir, U, Polasek, Ozren, McCarthy, M.I., Böttcher, Y, Shrader, P, Graessler, Jürgen, Wild, Sarah H; id_orcid, Luan, J., Collins, Francis S., Willenborg C, Mooser, Vincent E., Homuth, Georg, Arking, D, Deloukas, Panos, Mälarstig, Anders, Wareham, Nicholas J., O'Donnell, C, Bonnefond, A, Meigs, J.B., Dei, M, Greinacher, A., Stumvoll, Michael, Rader, DJ, Collins, FS, Wilson, James F., Chambers J, Pankow, James S., Zhao, JH, Egan, J.M., Nabila Bouatia-Naji, Li, Man, Willenborg, C, Bouatia-Naji, N, Vitart, V, Schlessinger, David, Illig, Thomas, Meitinger, Thomas, Wilson, James F.; id_orcid, Bumpstead, S., Morken, MA, Burnett-Miller MS, Hayward, C, Boinstein, Stefan R., Hamsten, A, Stewart, Alexandre F. R., Laakso, Markku, Meisinger, C., Strachan, DP, Coresh, J., Hadley, David, Stewart, Alexandre F R, Bornstein, Stefan R., Spector, TD, Barnes, D., Wheeler, Eleanor, Chambers, J, Roberts, R, Burnett-Miller, Mary Susan, Heath, Simon, Gallina, S., Altshuler, David, Bornstein, Stefan R, Tanaka, T, Balkau, B, Luan, Jian'an, Mägi, R., Ferrucci, L., Barnes, D, Wright B, Elosua, Roberto, Stolerman, E, Stewart AF, Mohlke, Karen L., Köttgen, A., Sandhu, Manjinder S., Deloukas, P, Jackson, AU, Tönjes, A, Franklin, C., Peden, JF, Bumpstead, Suzannah, Peltonen, L., Serena Sanna, Heeney, M. M., Ricketts SL, Hall, A, Uda, M, Hayward, C., Altshuler D, Samani, Nilesh J., Mälastig, A., Campbell, H, Campbell, Harry, Sandhu, Manjinder S, Bouatia-Naji, Nabila, Bonnefond, Amélie, Narisu, Narisu, Song, K, Langenberg, Claudia, Balkau, B., Wild, Sarah H.; id_orcid, Watkins, H, Wheeler, E, Voight, Benjamin F, Chambers, John, Devaney, JM, Fleming, MD, Schwarz, P, Ferrucci, Luigi, Soranzo, N, Siscovick, D, Kühnel, B, Martinez-Larrad, M.T., Meitinger, T., Fleming, Mark D., Grallert, H., Selvin, E, Chamber, John, Gallina, Sophie, Khaw, KT, Voight, BF, Egan, Josephine M., Hamsten, A., Roden, Michael, Ripatti, S, Inga Prokopenko, Reilly MP, Stumvoll, M, Sanna S, Hakonarson, Hakon H., Lathrop, M, März, W, Shrader, Peter, Kao, W. H.Linda, Gieger, C., Döring, A., Barroso, I., Kleber, M., Grazia Franzosi, Maria, Olla, Nazario, Winkelmann, Juliane, Fox, C.S., Meisinger, C, Epstein, SE, Chambers, J., Doering, Angela, Kühne, B., Olla, N, Li, M., Wright, B, Heeney MM, Grallert, Harald, Jula, A., Willemsen, Gonneke, Zabena, Carina, Kathiresan, S, Rader, Daniel J., Pedersen, NL, Köttgen, A, Rathmann, Wolfgang, Altshuler, D, Peltonen, Leena, Soranzo, N., Barnes D, Hall, Alistair, Mangino, Massimo, Bohm, B., de Geus, E.J.C.; id_orcid, Li, M, Boehnke, Michael, Völzke, Henry, Wichmann, HE, Arking D, Florez, J.C., Campbell, H., Hadley, D, Coresh, Josef, Wild, S.H., Thorsteinsdottir, Unnur, Steinthorsdottir, Valgerdur, Dörte Radke, Lecoeur, Cécile, Wilson, James F; id_orcid, Kovacs, P, Spector, Timothy D., Payne, F, Egan, Josephine M, Devaney, Joseph M., Kong, A, Song, Kjioung, Bumpstead S, McCarthy, Mark I., Saxena, Richa, Teumer, Alexander, Usala, Gianluca, Willemsen, G, Boomsma, D.I.; id_orcid, Thorleifsson, G, Kooner, J, Ricketts, SL, Illig, T, McCarthy MI, Boomsma, Dorret I, Epstein, Stephen E., Hottenga, JJ, Wright, Benjamin, Melander O, Williams, Gordon H., Peden, John F., Nauck, M, Williams, GH, Porcu, Eleonora, de Geus, E.J.C., Willemsen, G.; id_orcid, Prokopenko, I, Payne, Felicity, Rathmann, W., Knouff, CW, WTCCC, Lyssenko, Valeriya, Khaw, Kay-Tee, Surakka, I, Böttcher Y, Krohn, K, Kao WH, Ricketts, Sally L, Rudan, Igor, Langenberg, C., Stefansson, Kari, Florez, JC, Morken, Mario A., Porcu, E, Hakonarson, HH, Boomsma, Dorret I., McArdle, W.L., Kovacs, Peter, Melander, O., Hunter-Merrill, R, Stolerman E, Hunter-Merrill, Rachel, Clark R, Forouhi, Nita, Prokopenko, I., Soranzo, Nicole, Hayward, Caroline, Wheeler E, Bouatia-Naji N, Schwarz, Peter, Mägi, Reedik, Meigs JB, Salomaa V, O'Donnell, Chris, Voight, B.F., Devaney, Joseph M, Heeney, MM, Meitinger, T, Boutaia-Naji, N., Kao, WH, Pedersen NL, Pankow, JS, Gieger, Christian, Kühnel, Brigitte, Swift, Amy J., Surakka I, Homuth, V., Reilly, M. P., Boettcher, Yvonne, Boomsma, DI, Boomsma DI, Nicole Soranzo, Bonnycastle, L.L., Marz, W., Coresh, J, Mohlke, KL, McArdle, Wendy L, Mooser, VE, Loos, RJ, Nathan, DM, Hottenga, Jouke Jan, Stewart, AF, Franklin, C, Silveira, A, Herder, Christian, Clark, R, Kuusisto, Johanna, Bonnycastle, Lori L, Franklin, Christopher, Devaney, J.M., Thorleifsson, Gudmar, Sandhu, M. S., Stefansson K, Ricketts, Sally L., Devaney JM, Boerwinkle E, Luan, J, McArdle, WL, Winkelmann, J, Watkins, Hugh, Christian Gieger, Serrano-Ríos, M, Magnusson, P.K.E., Barroso, I, Bonnefond A, Döring A, Spector TD, Bonnycastle, Lori L., Willemsen, G., Balkau, Beverley, McPherson, Ruth, Melander, Olle, Reilly, Muredach P, Cao, Antonio, Tanaka, Toshiko, Heeney, Matthew M., Dupuis, J., Schlessinger, D, Hottenga, Jouke-Jan, Gallina, S, Schunkert, Heribert, Wellcome Trust Case Consortium (WTCCC) (), Radke, Doerte, Loos, R.J.F., Die, M., Forouhi, N., Franzosi, M.G., Boomsma, D.I., Wichmann, H. Erich, Kathiresan, Sekar, Wilson, JF, Stolerman, E., Jula, Antti, Florez, Jose C., Geus, E.J.C., van der Hout, Annemarie, Joseph M. Devaney, Froguel, Philippe, Bouatia-Naji, N., Rudan, I, Abecasis, G, Polasek O, Sally L. Ricketts, Grallert, H, Wild, Sarah H., Narisu, N, de Geus, Eco J. C., Balkau B, Döring, A, Sandhu, M.S., Swift, AJ, Soranzo N, Krohn, Knut, Clark, R., Khaw, Kay Tee, Magnusson, Patrik K.E., Selvin, Elizabeth, Lecoeur, C, Hayward, Caroline; id_orcid, Groop, Leif, Ripatti, Samuli, Langenberg C, Bumpstead, S, Polasek, O, McPherson, R., Campbell H, Froguel, P., Hamsten, Anders, Reilly, M.P., Froguel, P, Ricketts, S.L., Fox, Caroline S +586 morecore +1 more sourceSurfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions
Advanced Science, EarlyView.This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang +8 morewiley +1 more sourceOne‐Step Preparation of Lanthanide‐Doped Polyurea Multicolor Microspheres for Versatile Fluorescent Applications
Advanced Science, EarlyView.Lanthanide‐doped polyurea microspheres are prepared via a facile one‐step precipitation polymerization. They exhibit strong hydrogen‐bonding and coordination interactions with excellent properties, including multicolor emission, high quantum yield (75.3%), remarkable stability, redispersibility, and biocompatibility.Guiyu Zhang, Xiaoxia Yu, Xinhui Wang, Xiang Zheng Kong, Xiangling Gu, Jitao Liu, Shusheng Li, Xiaoli Zhu, Lianbao Cao, Xubao Jiang +9 morewiley +1 more sourceHemoglobin Himeji and inconsistent hemoglobin A1c values: a case report
Journal of Medical Case Reports, 2017 Background Hemoglobin A1c is used to evaluate the glycemic control in patients with diabetes and is a risk marker for chronic complications of diabetes. Hemoglobin variants are reported to falsely lower or increase hemoglobin A1c test results. We present Vânia Guedes, Rita Bettencourt-Silva, Joana Queirós, Maria da Luz Esteves, Maria José Teles, Davide Carvalho +5 moredoaj +1 more source
