Results 141 to 150 of about 86,632 (376)

Thermal-induced proteinquake in oxyhemoglobin [PDF]

open access: yesarXiv, 2015
Oxygen is released to living tissues via conformational changes of hemoglobin from R-state (oxyhemoglobin) to T-state (desoxyhemoglobin). The detailed mechanism of this process is not yet fully understood. We have carried out micromechanical experiments on oxyhemoglobin crystals to determine the behavior of the Young's modulus and the internal friction
arxiv  

3D Microtumors Representing Ovarian Cancer Minimal Residual Disease Respond to the Fatty Acid Oxidation Inhibitor Perhexiline

open access: yesAdvanced Healthcare Materials, EarlyView.
Minimal residual disease (MRD) leads to cancer relapse and poor survival in ovarian cancer. The lack of representative 3D models limits therapy development. The microfluidics‐based high throughput 3D microtumor platform described here generates clinically‐relevant MRD models. The 3D microtumors recapitulate the molecular signatures of MRD from patients.
Xingyun Yang   +14 more
wiley   +1 more source

Ischemic Myocardium Targeting Peptide‐Guided Nanobubbles for Multimodal Imaging and Treatment of Coronary Microvascular Dysfunction

open access: yesAdvanced Healthcare Materials, EarlyView.
Nanobubbles functionalized with indocyanine green and ischemic myocardium‐targeting peptide effectively target cardiomyocytes and enable the multimodal (fluorescence, ultrasonic, and photoacoustic) imaging of ischemic myocardium in mice with coronary microvascular dysfunction (CMD).
Bo Yu   +8 more
wiley   +1 more source

Comparison of the effects of acute moderate-and high-intensity aerobic exercise on changes in hematological parameters and exercise-induced thrombocytosis in female college futsal players

open access: yesفصلنامه دانشگاه علوم پزشکی جهرم, 2018
Introduction and Aims: Type, intensity and duration of exercise, determining the effect of exercise on haematological indexes. The aim of this study was comparison of the effects of acute moderate-and high-intensity aerobic exercise on some hematological
abdossaleh zar, ,
doaj  

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

open access: yesAdvanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto   +2 more
wiley   +1 more source

Avaliação do impacto de um suplemento nutricional rico em ferro hematínico

open access: yesCadernos de Saúde Pública
Estudo quase-experimental foi desenvolvido junto a 49 mulheres sadias para se avaliar o impacto de um produto do sangue bovino nos níveis hematológicos.
Miriam Correa de Carvalho Simões   +3 more
doaj  

The genetic architecture of adaptations to high altitude in Ethiopia [PDF]

open access: yesarXiv, 2012
Although hypoxia is a major stress on physiological processes, several human populations have survived for millennia at high altitudes, suggesting that they have adapted to hypoxic conditions. This hypothesis was recently corroborated by studies of Tibetan highlanders, which showed that polymorphisms in candidate genes show signatures of natural ...
arxiv  

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

open access: yesAdvanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq   +4 more
wiley   +1 more source

HEMOGLOBIN PRODUCTION FACTORS IN THE HUMAN LIVER [PDF]

open access: bronze, 1933
G. H. Whipple, F. S. Robscheit‐Robbins
openalex   +1 more source

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