Results 241 to 250 of about 89,531 (289)

Inhibiting Liver‐Derived C3 Protein Rescues Anesthesia/Surgery‐Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis

Advanced Science, EarlyView.
This study provides evidence that anesthesia/surgery can induce the BBB breakdown and promote the release of hepatogenous C3 protein into the blood. This surgical dual factors ultimately drove C3 to cross the damaged BBB and selectively colocalize with C3aR in the hippocampus, which results in structural and functional injury of synapse, C3aR‐mediated ...
Qianqian Wu, Peilin Cong, Zhouxiang Li, Yuxin Zhang, Huanghui Wu, Qian Zhang, Yawei Li, Li Tian, Qingyuan Miao, Yinggang Zheng, Hui Zhang, Qian Chen, Enduo Feng, Xinyang Li, Zheping Chen, Dong‐Xin Wang, Xinwei Huang, Lize Xiong   +17 more
wiley   +1 more source

Mechanisms of Globin Gene Regulation in Mammals. [PDF]

Annu Rev Genet
Hardison RC.
europepmc   +1 more source

Subventricular Zone‐on‐a‐Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage

Advanced Science, EarlyView.
A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni, Begüm Gökçe, Magnus Gram, Coco Holliday, Aylin Sendemir, Marimélia Aparecida Porcionatto, Anna Herland   +6 more
wiley   +1 more source

High-Oxygen-Affinity Hemoglobins-Case Series and Review of the Literature. [PDF]

J Clin Med
Komninaka V, Flevari P, Ntelaki EE, Yfanti E, Androutsakos T, Ntanasis-Stathopoulos I, Terpos E.   +6 more
europepmc   +1 more source

Replacement of the Distal Histidine Reveals a Noncanonical Heme Binding Site in a 2-on-2 Hemoglobin

, 2018
Dillon B. Nye, Juliette T. J. Lecomte
openalex   +2 more sources

Laser Ultrasound Super‐Resolution Imaging for Multi‐Parametric Non‐Invasive Volumetric Characterization of Brain Cancer

Advanced Science, EarlyView.
Laser ultrasound super‐resolution imaging (LUSSI) leverages laser‐generated ultrasound for functional 3D transcranial imaging of brain tumor vasculature. Combined with optoacoustic tomography, it is demonstrated in a glioblastoma model, revealing structural abnormalities, compressed vessels, hemorrhages, and hypoxic regions.
Daniil Nozdriukhin, Yi Chen, Shuxin Lyu, Daniel Razansky, Xosé Luís Deán‐Ben   +4 more
wiley   +1 more source

Impact of Hemoglobin Levels During Definite Chemoradiotherapy of Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma on Survival. [PDF]

Medicina (Kaunas)
Hazko S, Ahmed A, Hermann RM, Sonnhoff MA, Warnecke A, Bruns F, Blach R, Christiansen H, Becker JN.   +8 more
europepmc   +1 more source

Dynamic Arginine Methylation of YBX1 Relay Controls Its Phase Separation and Chemoradiotherapy Resistance in Rectal Cancer

Advanced Science, EarlyView.
Protein arginine methyltransferase 3 (PRMT3) induces the arginine methylation of Y‐box binding protein 1 (YBX1), which suppresses phase separation and is imperative for its nuclear translocation. Subsequently, lysine‐specific demethylase 4A demethylates YBX1 to unmask the R247 residue and promote its phase separation, which transcriptionally regulates ...
Yunxing Shi, Taixuan Wan, Shaoru Liu, Huashan Liu, Ziwei Zeng, Wenxin Li, Zhenxing Liang, Li Xiong, Shuanglin Luo, Yunfei Yuan, Liang Huang, Liang Kang   +11 more
wiley   +1 more source

Health outcomes of umbilical cord clamping techniques in preterm neonates: meta-analysis. [PDF]

Rev Assoc Med Bras (1992)
Bilgiç FŞ, Karaahmet AY, Alaybeyoğlu A.   +2 more
europepmc   +1 more source

Single Cell and Spatial Transcriptomics Define a Proinflammatory and Profibrotic Niche After Kidney Injury

Advanced Science, EarlyView.
By integrating single‐cell RNA sequencing and spatial transcriptomics, tenascin C (TNC) is unveiled as a central organizer of the proinflammatory and profibrotic niche in kidney fibrosis. TNC promotes macrophage activation through TLR4/NF‐κB signaling, leading to renal inflammation and fibrosis.
Li Li, Jinlin Liao, Yuxi Zhang, Zifu Yao, Junxin Huang, Kejia Wu, Lu Li, Yiling Peng, Haili Zhu, Xue Hong, Xi Liu, Lili Zhou, Fan Fan Hou, Haiyan Fu, Youhua Liu   +14 more
wiley   +1 more source