Results 241 to 250 of about 90,450 (338)

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Beyond Hemoglobin Concentration: How Intravascular Volume Measurements Can Advance Our Understanding of High-Altitude Adaptation. [PDF]

Am J Hum Biol
Tremblay JC, Siebenmann C, Stembridge M.
europepmc   +1 more source

Benefits of chronic blood transfusion in hemoglobin E/β thalassemia with pulmonary arterial hypertension

, 2014
Nonlawan Chueamuangphan, Jayanton Patumanond, Wattana Wongtheptien, Weerachai Nawarawong, Apichard Sukonthasarn, Suporn Chuncharunee, Chamaiporn Tawichasri   +6 more
openalex   +1 more source

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

The WELSH tool, is valid and sensitive to changes during the assessment of walking ability in severe anemia of pregnancy. [PDF]

Sci Rep
Ouédraogo N, Sempore WY, Tiendrebéogo AJF, Ouédraogo V, Nikiema G, Yaméogo TM, Abraham P.   +6 more
europepmc   +1 more source

Laboratory tests for diagnosis and treatment of diabetes mellitus-especially hemoglobin A1c.

, 2004
Makoto Tominaga
openalex   +2 more sources

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Association between polycystic ovary syndrome and systemic immune inflammation index and other inflammation markers; a case-control study. [PDF]

Afr Health Sci
Demirel F, Arikan II.
europepmc   +1 more source

PDB17 GLYCATED HEMOGLOBIN AS A SURROGATE MARKER FOR THE APPEARANCE AND PROGRESSION OF MACRO VASCULAR COMPLICATIONS IN TYPE 2 DIABETES MELLITUS: SYSTEMATIC REVIEW AND META-ANALYSIS

, 2010
A Weczorek, Anna Marcisz, P Rys, Iwona Skrzekowska-Baran, R Plisko, Magdalena Władysiuk   +5 more
openalex   +1 more source

Expandable Nanocomposite Shape‐Memory Hemostat for the Treatment of Noncompressible Hemorrhage

Advanced Science, EarlyView.
A nanocomposite‐coated shape memory foam rapidly expands, accelerates clotting, and reduces blood loss in vivo. Its fast volumetric expansion and strong procoagulant activity make it a promising hemostat for treating deep, noncompressible hemorrhage.
Saptarshi Biswas, Sarah E. Miller, Shounak Roy, Jeevika Thazhaiselvam, Samantha Foster, Manivannan Sivaperuman Kalairaj, Sasha M. George, Yava Jones‐Hall, Staci J. Horn, Fred J. Clubb, Taylor H. Ware, Duncan J. Maitland, Akhilesh K. Gaharwar   +12 more
wiley   +1 more source