Results 291 to 300 of about 90,450 (338)

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

Hemoglobin-to-Red Blood Cell Distribution Width Ratio and Erectile Dysfunction Among U.S. Adults: A Moderated Mediation Analysis of Body Roundness Index. [PDF]

Am J Mens Health
Wu Y, Wu Y, Dong X.
europepmc   +1 more source

Stress‐Programmed Immune Niches Fuel TNFR2+ Treg Activation and Drive Neoadjuvant Chemotherapy Resistance in Breast Cancer

Advanced Science, EarlyView.
Single‐cell sequencing reveals stress‐programmed immune states driving TNFα–TNFR2–mediated Treg activation and therapy resistance in breast cancer, while targeting this axis restores antitumor immunity. ABSTRACT The tumor microenvironment (TME) harbors diverse immune cell states that shape therapeutic outcomes in breast cancer.
Zhibo Shao, Xuliren Wang, Han Zhu, Ling Yao, Qi Zhang, Zihan Zhai, Xinyi Lv, Xinyuan Xia, Yi Zhang, Xinya Lu, Xinyi Quan, Jiawen Yang, Xinwei Li, Jieyi Dong, Zhi‐ming Shao, Ruoxi Wang, Bingqiu Xiu, Jiong Wu, Sheng Chen   +18 more
wiley   +1 more source

Protective Effect of Hemoglobin Treatment with Sodium Trimetaphosphate on Enamel Erosion: in vitro study. [PDF]

Braz Dent J
Ferrari CR, Kitamoto KSA, Francese MM, Pelá VT, Câmara JVF, Santos LA, Lussi A, Martins TP, Pessan JP, Buzalaf MAR.   +9 more
europepmc   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Hemoglobin β-F41K: A recombinant oxygen carrier prototype engineered for enhanced heme retention, stability, and optimal oxygenation properties. [PDF]

J Biol Chem
Khan MA, Yadav K, Signore AV, Mittal N, Uppal S, Tyagi AK, Mittal G, Storz JF, Kundu S.   +8 more
europepmc   +1 more source

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

High-Oxygen-Affinity Hemoglobins-Case Series and Review of the Literature. [PDF]

J Clin Med
Komninaka V, Flevari P, Ntelaki EE, Yfanti E, Androutsakos T, Ntanasis-Stathopoulos I, Terpos E.   +6 more
europepmc   +1 more source

Hubungan Antara Asupan Zat Besi dan Vitamin C dengan Kadar Hemoglobin Anggota TBM 110 FK UMI

Andi Muhammad Fadel Bambang, Nesyana Nurmadilla, Eny Arlini Wello, ⁠Asrini Safitri, Irna Diyana Kartika   +4 more
openalex   +2 more sources

Evaluation of anemia and iron status in Japanese patients with gynecological malignancy: retrospective cohort study : Author. [PDF]

BMC Womens Health
Kokabu T, Yamauchi S, Iwai M, Aoki K, Okamura A, Tarumi Y, Kataoka H, Yoriki K, Mori T.   +8 more
europepmc   +1 more source