Results 41 to 50 of about 7,137 (182)
Hemoglobinúria paroxística noturna e gravidez Paroxysmal nocturnal hemoglobinuria in pregnancy
Revista Brasileira de Ginecologia e Obstetrícia, 2004 A hemoglobinúria paroxística noturna é doença rara, causada por mutação adquirida de um gene no sistema hematopoético com 16-18% dos casos diagnosticados durante a gravidez.
Marcelo Luís Nomura +4 more
doaj +1 more source
The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta +2 more
wiley +1 more source
Haematologica, 2012 Background Patients with paroxysmal nocturnal hemoglobinuria harbor clonal glycosylphosphatidylinositol-anchor deficient cells arising from a multipotent hematopoietic stem cell acquiring a PIG-A mutation.
Jeffrey J. Pu +5 more
doaj +1 more source
eJHaem, Volume 7, Issue 4, August 2026.ABSTRACT Introduction Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder characterized by complement‐mediated hemolysis, thrombosis, bone marrow failure, and anemia. Although current treatments improve outcomes, patients still experience hemolysis and could remain anemic with a negative impact on quality of life (QoL).
Esther Natalie Oliva +22 more
wiley +1 more source
Brazilian Journal of Cardiovascular SurgeryParoxysmal nocturnal hemoglobinuria (PNH) is an ultra-orphan disease. We report the first case in the literature of Off-Pump Coronary Revascularization Using Bilateral Internal Thoracic Arteries in a patient with paroxysmal nocturnal hemoglobinuria. A 36-
Juan Mariano Vrancic +3 more
doaj +1 more source
Paroxysmal nocturnal hemoglobinuria: Pandora’s box?
Journal of Mind and Medical Sciences, 2020 Introduction. Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired non-malignant hematological disorder which affects the pluripotent hematopoietic stem cell.
Mihnea-Alexandru Găman +2 more
doaj +1 more source
European Journal of Clinical Investigation, Volume 56, Issue 8, August 2026.Serial biomarker assessment in 40 patients undergoing first‐time pulmonary vein isolation showed greater hemolysis and myocardial myolysis after FARAPULSE pentaspline single‐shot pulsed field ablation than after radiofrequency ablation. Myoglobin changes were associated with transient changes in renal function, albeit these exploratory correlations do ...
Paul Felix Harbich +9 more
wiley +1 more source
Haematologica, 2010 Background Paroxysmal nocturnal hemoglobinuria is an acquired hemolytic anemia characterized by intravascular hemolysis which has been demonstrated to be effectively controlled with eculizumab.
Anita Hill +6 more
doaj +1 more source
Paroxysmal Nocturnal Hemoglobinuria in Myelofibrosis [PDF]
Blood, 1970 Abstract Ten consecutive patients with myelofibrosis were examined for the following signs of PNH: Ham’s test, the sucrose hemolysis test, low red cell acetylcholinesterase (ACHE) activity and intravascular hemolysis. Two of the patients displayed all these signs and also had clinical symptoms of PNH.
N E, Hansen, S A, Killmann
openaire +2 more sources
American Journal of Hematology, Volume 101, Issue 7, Page 1597-1604, July 2026.ABSTRACT Sutimlimab is a monoclonal antibody against complement fraction C1s approved for the treatment of hemolytic anemia due to cold agglutinin disease (CAD). Here, we analyzed and report the largest international CAD cohort of sutimlimab‐treated patients ever reported to highlight its safety and effectiveness in the real‐world setting. We accrued a
Bruno Fattizzo +38 more
wiley +1 more source