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Paroxysmal Cold Hemoglobinuria
Hematology/Oncology Clinics of North America, 2015Paroxysmal cold hemoglobinuria is a rare cause of autoimmune hemolytic anemia predominantly seen as an acute form in young children after viral illnesses and in a chronic form in some hematological malignancies and tertiary syphilis. It is a complement mediated intravascular hemolytic anemia associated with a biphasic antibody against the P antigen on ...
Satish, Shanbhag, Jerry, Spivak
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Paroxysmal Nocturnal Hemoglobinuria
Mayo Clinic ProceedingsParoxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired clonal hematologic disorder characterized by intravascular destruction of red blood cells by the complement system. This intravascular hemolysis can lead to a constellation of symptoms, including anemia, fatigue, shortness of breath, smooth muscle dystonia, and dark urine that is classically
Richard C. Godby, Surbhi Shah
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Hemoglobinuria With Ribavirin Treatment
Journal of Clinical Gastroenterology, 2003Chronic hepatitis C virus is a major worldwide cause of hepatitis, cirrhosis, end-stage liver disease, and hepatocellular carcinomas. Combination therapy of ribavirin with short- or long-acting interferon-alpha is now the standard treatment of chronic hepatitis C. This therapy is associated with a wide range of side effects.
Omar I, Massoud +2 more
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PAROXYSMAL COLD HEMOGLOBINURIAS
Archives of Internal Medicine, 1948DRESSLER 1 is credited with having first reported observations on a case of "paroxysmal cold hemoglobinuria," a symptom complex now known to have two separate and distinct etiologic bases. The first and more generally recognized type is syphilitic paroxysmal cold hemoglobinuria, a disease seen in a small percentage of persons with syphilis and caused ...
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Paroxysmal Cold Hemoglobinuria
CRC Critical Reviews in Clinical Laboratory Sciences, 1978The clinical and hematological features of a rare autoimmune disorder, PCH, are reviewed. Based on the case reports of 24 patients suffering from this disease, the presence of cold hemolysins in the sera of these patients as the main cause for the red cell destruction following exposure to cold is further discussed.
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American Journal of Diseases of Children, 1935
Hemoglobinuria is rare in childhood. The case reported here is the only one observed in 12,393 infants and children admitted to the medical service of the Los Angeles Children's Hospital from 1920 to 1933. Pediatric literature contains occasional references to this symptom, chiefly as occurring in prenatal syphilis in the form known as paroxysmal ...
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Hemoglobinuria is rare in childhood. The case reported here is the only one observed in 12,393 infants and children admitted to the medical service of the Los Angeles Children's Hospital from 1920 to 1933. Pediatric literature contains occasional references to this symptom, chiefly as occurring in prenatal syphilis in the form known as paroxysmal ...
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Paroxysmal Nocturnal Hemoglobinuria
1992Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal disorder of the hematopoietic stem cell (Hartmann and Arnold 1977) resulting in the production of blood cells which are defective in that they lack or are markedly deficient in glycan-phosphatidylinositol (GPI)-linked surface proteins (Rosse 1990a).
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Paroxysmal Nocturnal Hemoglobinuria in Children
Pediatric Drugs, 2007Paroxysmal nocturnal hemoglobinuria (PNH), an acquired hematologic disorder characterized by intravascular hemolysis, nocturnal hemoglobinuria, thrombotic events, serious infections, and bone marrow failure, is very rare in children. PNH is caused by a somatic mutation of the phosphatidylinositol glycan (GPI) complementation class A (PIGA) gene ...
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