Results 151 to 160 of about 89,871 (313)
PepTune: De Novo Generation of Therapeutic Peptides with Multi-Objective-Guided Discrete Diffusion [PDF]
arXivPeptide therapeutics, a major class of medicines, have achieved remarkable success across diseases such as diabetes and cancer, with landmark examples such as GLP-1 receptor agonists revolutionizing the treatment of type-2 diabetes and obesity. Despite their success, designing peptides that satisfy multiple conflicting objectives, such as target ...
arxiv
Advanced Science, EarlyView.The manuscript designs a type of SA Mn‐CDs with low coordination Mn‐N2 configuration hydrothermally synthesized by chelating manganese atoms with ethylenediamine tetraacetic acid. SA Mn‐CDs not only have more active sites at the atomic level for high efficiently peroxidase‐like activity but also show excellent fluorescent ability at the cellular and ...
Peiwei Jin +8 more
wiley +1 more source
BioTD: an online database of biotoxins [PDF]
arXivBiotoxins, mainly produced by venomous animals, plants and microorganisms, exhibit high physiological activity and unique effects such as lowering blood pressure and analgesia. A number of venom-derived drugs are already available on the market, with many more candidates currently undergoing clinical and laboratory studies.
arxiv
ATTACKS OF HEMOLYSIS IN RAYNAUDʼS DISEASE [PDF]
, 1921 A. Souques, Richard Moreau
openalex +1 more source
Advanced Science, EarlyView.Multiple therapeutic modalities combined in a synergistic way that can modulate different immune axes are demonstrated potentially effective in boosting immunotherapy. A nucleic acid‐locked smart carrier (NASC) performed as an “all‐in‐one” nanoplatform is constructed for efficient eliciting chemo‐ and photothermal‐amplified immunogenic cell death to ...
Jiayang Zhang +6 more
wiley +1 more source
Osmotic properties of the erythrocyto. I. Introduction. A simple method for studying the rate of hemolysis [PDF]
, 1932 openalex +1 more source
Advanced Science, EarlyView.Through elaborate design, a biodegradable scaffold with excellent mechanical properties and suitability is fabricated, providing spatial support for subsequent physiological activities. The prepared GA‐HBC‐LIC hydrogel possesses sequential antibacterial, antioxidant, anti‐inflammatory and immunomodulatory functions, offering a suitable chemical and ...
Jiafei Chen +9 more
wiley +1 more source
Aggregate, EarlyView.Herein, we used the Mott–Schottky effect to synthesize an ultrafine‐Mn‐loaded N,O‐doped porous nanocarbons (Mn‐PNCs) nanozyme. The fabricated Mn‐PNCs nanozyme using a sustainable and efficient heteroatom‐doped strategy exhibited excellent photothermal‐enhanced, peroxidase‐like activity, thereby contributing to effective antibacterial treatment for ...
Xueyu Jiang +5 more
wiley +1 more source
Aggregate, EarlyView.Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai +6 more
wiley +1 more source