Results 201 to 210 of about 200,118 (403)

PepTune: De Novo Generation of Therapeutic Peptides with Multi-Objective-Guided Discrete Diffusion [PDF]

arXiv
We present PepTune, a multi-objective discrete diffusion model for simultaneous generation and optimization of therapeutic peptide SMILES. Built on the Masked Discrete Language Model (MDLM) framework, PepTune ensures valid peptide structures with a novel bond-dependent masking schedule and invalid loss function.
arxiv  

An Intelligent and Conductive Hydrogel with Multiresponsive and ROS Scavenging Properties for Infection Prevention and Anti‐Inflammatory Treatment Assisted by Electrical Stimulation for Diabetic Wound

Advanced Science, EarlyView.
This study introduces a novel therapeutic approach that employs a conductive hydrogel (HEPP) responsive to near‐infrared light, pH levels, and reactive oxygen species. Its goal is to enhance the healing environment affected by elevated glucose levels, insufficient oxygen, and bacterial infections in diabetes‐related wounds.
Tao Zhang, Zongwu Meng, Haoyu Yu, Ping Ding, Tianhan Kai   +4 more
wiley   +1 more source

The Adrenal Cortex and Hemolysis [PDF]

, 1953
J. D. Feldman, M. Rachmilewitz, Oliver Stein, Y. Stein   +3 more
openalex   +1 more source

VALIDACIÓN INTRALABORATORIO DE UNA METODOLOGÍA ANALÍTICA POR ESPECTROFOTOMETRÍA UV/VIS PARA EVALUAR EL POTENCIAL IRRITANTE OCULAR DE TENSOACTIVOS EN GLÓBULOS ROJOS INTRALABORATORY VALIDATION OF AN ANALYTICAL METHODOLOGY BY UV/VIS SPECTROMETRY IN ORDER TO EVALUATE THE OCULAR IRRITANT POTENTIAL OF TENSOACTIVES IN RED BLOOD CELLS

Vitae, 2011
Se presentan los resultados de la validación intralaboratorio para los parámetros de linealidad, repetibilidad y precisión intermedia del ensayo en glóbulos rojos, metodología in vitro empleada para evaluar la irritación ocular.
Luz A LEGUIZAMÓN B, Ever A HERRERA C, Jorge A MARTÍNEZ R, María C LOZANO A   +3 more
doaj  

Multi-Objective-Guided Discrete Flow Matching for Controllable Biological Sequence Design [PDF]

arXiv
Designing biological sequences that satisfy multiple, often conflicting, functional and biophysical criteria remains a central challenge in biomolecule engineering. While discrete flow matching models have recently shown promise for efficient sampling in high-dimensional sequence spaces, existing approaches address only single objectives or require ...
arxiv  

Polymer Brush‐Based Asymmetric Porous Patch with Excellent Anti‐Bacterial and Anti‐Contamination Properties Enables Infectious Abdominal Wall Defect Repair

Advanced Science, EarlyView.
A zwitterionic asymmetric patch is developed via self‐induced phase separation. The cationic layer exhibits anti‐bacterial efficacy and releases pro‐healing factor, while the zwitterionic hydrogel prevents contamination and visceral adhesion. The strong mechanical interlocking of two layers leads to a high and stable burst pressure tolerance.
Zeping Huang, Weiwen Liang, Binying Peng, Yang Ouyang, Zixin Chen, Mawsoom Mamut, Zhipeng Huang, Hui Wang, Rongkang Huang, Bo Ma, Bingna Zheng, Jian Cai   +11 more
wiley   +1 more source

VARIATIONS IN RESISTANCE OF BLOOD CELLS TO HEMOLYSIS [PDF]

, 1917
B. W. Rhamy
openalex   +1 more source

A hem érfal komponensekre kifejtett közvetlen és közvetett patofiziológiai hatásai = Pathologic effects of heme on components of vessel wall via direct and indirect mechanisms [PDF]

, 2010
Kimutattuk, hogy az atheroma lipid magja prooxidáns környezetet teremt, ahol a vörösvértestek szétesnek, a hemoglobin ferri- és ferrylhemoglobinná oxidálódik, és a felszabaduló hem és vas lipidoxidációt indít el.
Balla, György, Balla, József, Galajda, Zoltán, Jeney, Viktória, Szentmiklósi, József András, Varga, Zsuzsa   +5 more
core  

In Situ and Real‐Time Multi‐Modality Imaging Guided Orderly Triple‐Therapy of Tumors with a Multifunctional Nanodrug

Advanced Science, EarlyView.
A multifunctional AuNR@SiO2@MnO2@ DNA prodrugs (ASMD) nanodrug is designed to establish an in situ and real‐time photoacoustic (PA)/magnetic resonance (MR)/fluorescence (FL) multi‐modality imaging guided orderly photothermal therapy (PTT)/chemodynamic therapy (CDT)/gene therapy (GT) triple‐therapy of tumor.
Chaoyi Yang, Yuexuan Meng, Ying An, Jing Jia, Yuru Wang, Guangming Li, Yiran Li, Shan Wu, Chengyao Geng, Yunlong Chen, Huangxian Ju   +10 more
wiley   +1 more source

THE MECHANISM OF THE INHIBITION OF HEMOLYSIS [PDF]

, 1945
Eric Ponder
openalex   +1 more source