Idiopathic Intracranial Hypertension Is Characterized by a Distinct Proteomic Profile
Annals of Neurology, EarlyView.Objectives The pathophysiology of idiopathic intracranial hypertension (IIH) is poorly understood and disease‐specific biomarkers are lacking. We aimed to shed light on IIH pathophysiology and identify disease‐specific biomarkers. Methods This prospective cross‐sectional cohort study included patients with new‐onset IIH and age‐, body mass index‐, and ...
Santosh D. Bhosale +17 more
wiley +1 more source
Angewandte Chemie, EarlyView.We prepared five glycosylated liposomal nanoparticles (G‐LNPs) to investigate the role of glycosylation and protein corona in modulating the in vivo behavior of G‐LNPs. We show that IgG and complement C3 adsorption enhanced liposomal nanoparticle clearance, with IgG promoting subsequent C3 binding.
Yingjie Yu +18 more
wiley +2 more sources
Efficacy and Safety of Treatments for Paroxysmal Nocturnal Hemoglobinuria: A Systematic Literature Review. [PDF]
J Clin MedGandhi S +6 more
europepmc +1 more source
Advanced NanoBiomed Research, EarlyView.Selenium nanoparticles (SeNPs) are emerging as multifunctional platforms for wound healing, integrating antimicrobial, anti‐inflammatory, and proregenerative activities. This review summarises key mechanisms and recent advances in SeNP‐enabled composite dressings, immunomodulatory nanocomposites, microenvironment‐responsive hydrogels, photothermal and ...
Yangxia Chen +10 more
wiley +1 more source
Mechanically Regulated Nanozymes for Remote Metabolic Reprogramming and Precise Cancer Therapy
Angewandte Chemie, EarlyView.Inspired by mechanoenzymes, a ferrocene‐based mechanically regulated nanozyme converts acoustic shear force into enhanced peroxidase‐like activity by decreasing electron density and alleviating steric hindrance at the Fe active sites, thereby rewiring redox homeostasis. Leveraging this remote regulatory mechanism, a multienzyme‐regulated nanoreactor is
Fangman Chen +13 more
wiley +2 more sources
Galectin-3 Mediates Heme-Induced Multi-Organ Dysfunction by Modulating the Splenic Immune Microenvironment. [PDF]
DiseasesMilinkovic M +2 more
europepmc +1 more source
Tunable Regional Targeting of Self‐Assembling Peptide Nanomaterials in Acute Myocardial Infarction
Advanced NanoBiomed Research, EarlyView.In a rat model of acute myocardial infarction, intravascular delivery of peptide nanofibers with a collagen‐targeting peptide bound to the infarct vasculature while globular peptide nanoparticles penetrated into the infarct area. This study demonstrated that size, shape, and surface chemistry of nanomaterials control the delivery location within the ...
Alexander Chen +14 more
wiley +1 more source
Advances in BODIPY Derivatives for Antibacterial Phototherapy
Angewandte Chemie, EarlyView.This review systematically summarizes the design strategies and structure‐activity relationships of BODIPY‐based antibacterial phototherapy, covering molecular engineering of small‐molecule photosensitizers and nanoplatforms, bacterial targeting and carrier design, and discussing the challenges and future perspectives associated with clinical ...
Li Lv +9 more
wiley +2 more sources
Functional reprogramming of melittin by Pluronic<sup>®</sup> F-127 enables anticancer selectivity with attenuated hemolytic activity. [PDF]
Front OncolKról G +7 more
europepmc +1 more source
Cold Gas Plasma Induces Platelet Activation and Hemostasis in Native and Anticoagulated Human Blood
Advanced NanoBiomed Research, EarlyView.Cold physical gas plasma induces platelet activation and hemostatic responses in native and anticoagulated human blood. Treatment efficacy depends on plasma parameters, including gas composition, distance, and exposure mode, which govern reactive species delivery and energy transfer.
Sander Bekeschus +5 more
wiley +1 more source