Results 261 to 270 of about 216,432 (383)

From Spark to Flame: ROS‐ and Light‐Cascade Activatable NIR‐II AIE Probe for Precise Tumor Imaging and Self‐Amplifying Phototherapy

open access: yesAdvanced Science, EarlyView.
ROS‐ and NIR light‐cascade activatable NIR‐II AIE theranostic probe (TT‐DHIn) is developed by integration of dihydroindole skeleton with oxidative dehydrogenation reaction mechanism and AIE skeleton with a twisted configuration. Upon ROS in the tumor microenvironment and NIR light activation, TT‐DHIn can achieve dual‐model imaging‐guided precise tumor ...
Xiaohui Chen   +12 more
wiley   +1 more source

Under‐Urine‐Adhered Supramolecular Hydrogel with Linearly Sustained Quercetin Release Facilitates Hemorrhagic Cystitis Healing via Inflammation Regulation

open access: yesAdvanced Science, EarlyView.
A supramolecular gelatin‐based hydrogel adhesive was engineered for hemorrhagic cystitis management. It provides robust wet‐tissue adhesion, rapid hemostasis, sustained quercetin release, effectively restoring the bladder barrier via anti‐inflammatory and antioxidant actions.
Xu Cao   +10 more
wiley   +1 more source

Engineering Metal‐Organic‐Framework‐Based STING Nanoagonists for PROTAC‐Enhanced Cancer Chemo‐Metalloimmunotherapy

open access: yesAdvanced Science, EarlyView.
Schematic overview of PROTAC‐enhanced chemo‐metalloimmunotherapy, integrating senescence induction, multi‐modal STING pathway activation, PD‐L1 blockade, and immune amplification via coordinated PROTACs, metal ions, and chemotherapy to elicit robust antitumor immunity and circumvent immune evasion.
Zhenzhen Chen   +3 more
wiley   +1 more source

Spatiotemporally Controlled Tumor Photodynamic/Immunotherapy Therapy Based on Upconversion Hybrid Nanosystem

open access: yesAdvanced Science, EarlyView.
PURH is constructed by a five‐layer upconversion nanoparticle (UCNP) surface coated with mesoporous silica, which encapsulates rose bengal (RB) within the mesoporous channels. Additionally, CpG oligonucleotides (CpG ODN) is linked to the surface, followed by the surface functionalization of hyaluronic acid (HA). This spatiotemporally controllable smart
Fang Wang   +9 more
wiley   +1 more source

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