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Hemolytic Uremic Syndrome [PDF]

Journal of the American Society of Nephrology, 2005
Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy defined by thrombocytopenia, nonimmune microangiopathic hemolytic anemia, and acute renal failure. The most frequent form is associated with infections by Shiga-like toxin-producing bacteria (STEC-HUS).
Marina Noris, Giuseppe Remuzzi
openaire   +6 more sources

The hemolytic uremic syndrome

Kidney International, 1995
HUS is the most common cause of acute renal failure in infants and young children and follows a diarrheal prodrome about 90% of the time. Persuasive evidence shows that virtually all of postdiarrheal cases are caused by EHEC infections, and that the great majority of cases in the United States are caused by the EHEC serotype O157:H7.
Piero Ruggenenti, Giuseppe Remuzzi
openaire   +7 more sources

A Rare Case: Improved Heart Failure with Anti-Complement Therapy in Complement-Dependent Hemolytic Uremic Syndrome [PDF]

, 2023
MakaleWOS:000925209300014xtrarenal involvement occurs in approximately 20% of patients with complement-mediated hemolytic-uremic syndrome. The involvement is usually of the nervous system, and cardiac involvement occurs in 3%-10% of patients.
Selçuk, Nedim Yılmaz, Tonbul, Halil Zeki, Türkmen, Kültigin, Özer, Hakan, Öztürk, Yasin   +4 more
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Eculizumab is a safe and effective treatment in pediatric patients with atypical hemolytic uremic syndrome [PDF]

, 2016
Atypical hemolytic uremic syndrome (aHUS) is caused by alternative complement pathway dysregulation, leading to systemic thrombotic microangiopathy (TMA) and severe end-organ damage.
Al-Akash, Samhar I, Ardissino, Gianluigi, Bedrosian, Camille L, Evans, Jonathan, Fila, Marc, Greenbaum, Larry A, Henning, Paul, Licht, Christoph, Lieberman, Kenneth V, Maringhini, Silvio, Ogawa, Masayo, Pape, Lars, Rees, Lesley, van de Kar, Nicole CAJ, Vande Walle, Johan   +14 more
core   +2 more sources

Infection frequently triggers thrombotic microangiopathy in patients with preexisting risk factors : a single-institution experience [PDF]

, 2010
Thrombotic microangiopathies are rare conditions characterized by microangiopathic hemolytic anemia, microthrombi, and multiorgan insult. The disorders, which include hemolytic uremic syndrome and thrombotic thrombocytopenic purpura, are often acute and ...
Catlow, Jamie, Douglas, Kenneth W., Green, Rachel, Pollock, Kevin G.J., Young, David   +4 more
core   +1 more source

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice [PDF]

, 2019
Atypical hemolytic uremic syndrome (aHUS) is frequently associated in humans with loss-of-function mutations in complement-regulating proteins or gain-of-function mutations in complement-activating proteins.
Smith-Jackson, Kate, Yang, Yi, Denton, Harriet, Pappworth, Isabel Y, Cooke, Katie, Barlow, Paul N, Atkinson, John P, Liszewski, M. K, Pickering, Matthew C, Kavanagh, David, Cook, H. T, Marchbank, Kevin J   +11 more
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An expert discussion on the atypical hemolytic uremic syndrome nomenclature-identifying a road map to precision: a report of a National Kidney Foundation Working Group. [PDF]

The term atypical hemolytic uremic syndrome has been in use since the mid-1970s. It was initially used to describe the familial or sporadic form of hemolytic uremic syndrome as opposed to the epidemic, typical form of the disease. Over time, the atypical
Burwick, R., Cataland, S., Chaturvedi, S., Cook, H.T., Cuker, A., Dixon, B.P., Fakhouri, F., Feldman, D.L., Hingorani, S.R., Java, A., Kavanagh, D., Leung, N., Licht, C., Nester, C.M., Noris, M., O'Shaughnessy, M.M., Parikh, S.V., Peyandi, F., Remuzzi, G., Smith, RJH, Sperati, C.J., van de Kar, NCAJ, Vivarelli, M., Waldman, M., Walker, P.   +24 more
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Clinical surveillance of thrombotic microangiopathies in Scotland, 2003-2005 [PDF]

, 2007
The prevalence, incidence and outcomes of haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopaenic purpura (TTP) are not well established in adults or children from prospective studies. We sought to identify both outcomes and current management
D. YOUNG, Hosler, K. G. J. POLLOCK, Marques, Sadler, T. J. BEATTIE, Tarr, Van Dyck, W. T. A. TODD   +8 more
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Prevalence and antimicrobial susceptibility of Escherichia coli O157 in beef at butcher shops and restaurants in central Ethiopia [PDF]

, 2017
Background: Ethiopia bears the largest burden of foodborne diseases in Africa, and diarrheal diseases are the second leading causes of premature deaths.
Beyene, Takele, Beyene, Tariku Jibat, Beyi, Ashenafi Feyisa, Cox, Eric, De Zutter, Lieven, Fite, Akafete Teklu, Genu, Tadele, Goddeeris, Bruno, Kaba, Tamirat, Korsa, Mesula Geloye, Tadesse, Fanos, Tafese, Asdesach, Tora, Ephrem   +12 more
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Hemolytic Uremic Syndrome

Pediatrics in Review, 2020
1. Bernarda Viteri, MD* 2. Jeffrey M. Saland, MD† 1. *Children’s Hospital of Philadelphia, Philadelphia, PA 2. †Mount Sinai Kravis Children’s Hospital, New York, NY Thrombotic microangiopathy (TMA) was described by Moschcowitz in 1924, and the term hemolytic uremic syndrome (HUS) appeared by 1955 to describe a series of patients with small ...
Bernarda Viteri, Jeffrey M. Saland
  +8 more sources