Results 61 to 70 of about 17,771 (179)

Exercise‐induced vasculitis with histological and genetic evidence of complement involvement

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Massimo Cugno, Paolo Calzari, Alessandra Di Benedetto, Francesca Laura Boggio, Chiara Moltrasio, Luigi Porcaro, Angelo Valerio Marzano   +6 more
wiley   +1 more source

Atypical hemolytic uremic syndrome

Renal Replacement Therapy, 2017
Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure.
Yoko Yoshida, Hideki Kato, Masaomi Nangaku   +2 more
doaj   +1 more source

Integrative Modular, Network‐Based, and Machine Learning Framework for Predicting Accessory Genome Functions and Virulence in Escherichia coli O157:H7

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
An analysis of the accessory genomes from 77 Escherichia coli O157:H7 strains using network and machine learning techniques uncovers modular communities of plasmid‐related virulence associated with IncF replicons. Accessory markers that are not directly linked to toxin genes can effectively predict the virulence status with an AUC of 0.85, facilitating
Sydney Menzeko Gambushe, Oliver Tendayi Zishiri   +1 more
wiley   +1 more source

Multiple Myeloma as the Underlying Cause of Thrombotic Microangiopathy Leading to Acute Kidney Injury: Revisiting a Very Rare Entity

Journal of Investigative Medicine High Impact Case Reports, 2017
Thrombotic microangiopathy (TMA) describes a pathological process of microvascular thrombosis, consumptive thrombocytopenia, and microangiopathic hemolytic anemia, leading to end-organ ischemia and infarction, affecting particularly the kidney and brain.
Savneek Chugh MD, Asim Kichloo MD, Firas Jafri MD, Liga Yusvirazi MD, Robert Lerner MD   +4 more
doaj   +1 more source

Role of eculizumab in a pediatric refractory gemcitabine-induced thrombotic microangiopathy: a case report

Journal of Medical Case Reports, 2017
Background The incidence of gemcitabine-induced hemolytic uremic syndrome has already been described in adults. Several approaches have been employed in the treatment of gemcitabine-induced hemolytic uremic syndrome with different outcomes.
Ludovica Facchini, Maurizio Lucchesi, Alessia Stival, Rosa Maria Roperto, Francesca Melosi, Marco Materassi, Silvia Farina, Veronica Tintori, Maurizio de Martino, Iacopo Sardi   +9 more
doaj   +1 more source

Prevalence, Antimicrobial Resistance, and Resistance Gene Profiles of Extended‐Spectrum β‐Lactamase‐Producing Escherichia coli and Klebsiella pneumoniae Isolated From Quails in Sylhet, Bangladesh

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
This study investigated the molecular epidemiology and antimicrobial resistance of Escherichia coli and Klebsiella pneumoniae isolated from quails in Bangladesh. High prevalence of E. coli, including Shiga toxin‐producing strains, and widespread multidrug resistance were observed.
Md. Al Mamun, Hemayet Hossain, Md. Shahidur Rahman Chowdhury, Shahida Begum Nargis, Munni Rani Das, Rakibul Hasan, Nasrin Akter Liza, Shuvojit Mitra, Md Bashir Uddin, Md. Mukter Hossain, Md. Mahfujur Rahman   +10 more
wiley   +1 more source

Bioartificial Livers Developed From Gene‐Edited Pig Hepatocyte Organoids Improve Amino Acid and Lipid Profiles in the Plasma of Patients With Liver Failure

MedComm, Volume 7, Issue 6, June 2026.
A bioartificial liver (BAL) integrating GGTA1‐knockout porcine hepatocytes and R‐spondin1‐overexpressing endothelial organoids was tested using plasma from patients with acute‐on‐chronic liver failure (ACLF). The BAL system actively modulates amino acid and lipid metabolism, enhances detoxification, partially restores overall metabolic balance, and ...
Yuting He, Yang Deng, Xinglong Zhu, Mengyu Gao, Qin Liu, Wanliu Peng, Yanyan Zhou, Lang Bai, Ji Bao   +8 more
wiley   +1 more source

Ribosomal Proteins in Cell Biology and Cancer

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The functions of ribosomal proteins (RPs) extend beyond the conventional translation process, as they also regulate gene expression, stress responses, and disease progression. Dysregulation of RPs contributes to the onset and progression of various diseases, including cancer and ribosomopathies, underscoring their dual role as critical disease ...
Ao Zhang, Zeguang Sun, Xinyang Song, Xikun Zhou, Jing Li   +4 more
wiley   +1 more source

Reply to Letter: “Limitations of Complement Activity Assays as Biomarkers for Ravulizumab Therapeutic Monitoring” by Saccà and Pelto Regarding “Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab”

Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1303-1304, June 2026.
Lea Gerischer, Jutta Schroeder‐Braunstein, Guido Wabnitz, Andreas Meisel   +3 more
wiley   +1 more source

Randomised, phase 1 evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of iptacopan in healthy volunteers

British Journal of Pharmacology, Volume 183, Issue 11, Page 2874-2889, June 2026.
Abstract Background and Purpose Overactivation of the alternative pathway (AP) underlies several diseases. Iptacopan is an oral, first‐in‐class, highly potent specific inhibitor of factor B, a key AP protease. Experimental Approach The analysis included data from two phase 1 randomised, volunteer‐blinded, placebo‐controlled studies: Study 1, a single ...
Irina Baltcheva, Guido Junge, Kenneth Kulmatycki, Robert Schmouder, Anna Schubart, Marie‐Anne Valentin   +5 more
wiley   +1 more source