Results 211 to 220 of about 4,984,986 (258)

Electron compensation‐gated nanomotor for immunomodulation and microenvironment remodeling in bacterial pneumonia therapy

open access: yesBMEMat, EarlyView.
A nanomotor featuring an “electronic lock” via electron compensation in an Au‐Ag alloy ensures therapeutic precision. Near‐infrared light acts as a key, unlocking on‐demand Ag+ release for synergistic bactericidal action and microenvironment remodeling to potently treat bacterial pneumonia. Abstract Bacterial pneumonia treatment is severely hampered by
Chenglong Xue   +4 more
wiley   +1 more source

Small scale purification and biophysical characterization of haptoglobin derived from human Cohn fraction IV

open access: yesBiotechnology Progress, EarlyView.
Abstract Haptoglobin (Hp) is a polymorphic acute phase α‐2 glycoprotein found in plasma that plays a critical role in binding, neutralizing, and removing cell‐free hemoglobin (Hb) from the circulation. Under clinical conditions characterized by high levels of hemolysis, such as in patients with sickle cell disease (SCD), large quantities of cell‐free ...
Shuwei Lu   +5 more
wiley   +1 more source

Transcatheter Tricuspid Valve Replacement for Residual Tricuspid Regurgitation After TEER

open access: yesCatheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Residual or recurrent tricuspid regurgitation (TR) after prior transcatheter tricuspid edge‐to‐edge (T‐TEER) repair occurs in about 12% of patients within 1 year. Since surgical tricuspid valve repair or replacement is of high risk, treatment options remain scarce.
Fabian Voß   +14 more
wiley   +1 more source

Mechanisms and Management of Acquired Aseptic Intracardiac Communications After Transcatheter Aortic Valve Implantation: Single‐Center Case Series Insights

open access: yesCatheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Acquired aseptic intracardiac communications (AICCs) are rare but clinically relevant structural complications following transcatheter aortic valve implantation (TAVI), typically resulting from mechanical injury to the aortic annulus, interventricular septum, or adjacent structures.
Geza Fontos   +6 more
wiley   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi   +5 more
wiley   +1 more source

Impact of Drone Versus Car Transport on Anti‐Doping Sample Integrity Over Short Distances: A Proof‐Of‐Concept Study

open access: yesDrug Testing and Analysis, EarlyView.
This proof‐of‐concept study evaluated the impact of short‐distance drone transport on anti‐doping sample integrity compared with traditional car transport. Targeted assays and untargeted metabolomics revealed equivalent biological profiles between methods, confirming that drone delivery preserves sample integrity for the athlete biological passport ...
I. Al‐Mohannadi   +13 more
wiley   +1 more source

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