Results 221 to 230 of about 36,076 (253)

Consensus-Based Guidelines for the Recognition, Diagnosis, and Management of Hemophagocytic Lymphohistiocytosis in Critically Ill Children and Adults

Critical Care Medicine, 2021
OBJECTIVE: Hemophagocytic lymphohistiocytosis is a hyperinflammatory syndrome that often requires critical care support and remains difficult to diagnose.
MD Melissa R. Hines, MD Tatiana von Bahr Greenwood, MD Gernot Beutel, MD Karin Beutel, MD J. Allyson Hays, MD PhD AnnaCarin Horne, MD Gritta Janka, MD Michael B. Jordan, MD Jan A. M. van Laar, MD Gunnar Lachmann, MD Kai Lehmberg, MD PhD Rafal Machowicz, MD Päivi Miettunen, MD Paul La Rosée, MD Bita Shakoory, MD Matt S. Zinter, MD PhD Jan-Inge Henter   +16 more
semanticscholar   +1 more source

Validation of the HScore and the HLH‐2004 diagnostic criteria for the diagnosis of hemophagocytic lymphohistiocytosis in a multicenter cohort

European Journal of Haematology, 2022
Timely diagnosis of hemophagocytic lymphohistiocytosis (HLH) is critical and relies on clinical judgment. The HLH‐2004 criteria are commonly used diagnostic criteria, whereas HScore was recently developed for reactive HLH.
L. Bilston, Jennifer Croden, M. Taparia, M. Karkhaneh, J. Grossman, H. Sun   +5 more
semanticscholar   +1 more source

Virus‐triggered secondary hemophagocytic lymphohistiocytosis

Acta paediatrica, 2021
Primary (familial/hereditary) and secondary (non‐familial/hereditary) hemophagocytic lymphohistiocytosis (HLH) are hyperinflammatory and hypercytokinemic syndromes. Secondary HLH includes infection‐ (eg viral/bacterial/fungal/parasitic) and non–infection‐
S. Imashuku, A. Morimoto, E. Ishii
semanticscholar   +1 more source

Familial hemophagocytic lymphohistiocytosis

Diagnostic Cytopathology, 1988
AbstractThe cytologic features of familial hemophagocytic lymphohistiocytosis in two infant siblings were reviewed and compared to the histopathologic features in the same cases. The cytologic features of familial hemophagocytic lymphohistiocytosis in imprint smears from the spleen, lymph nodes, and liver were distinct, with proliferation of benign ...
M F, Lachman, E H, Vogel, K, Kim
openaire   +2 more sources

Benefit of Anakinra in Treating Pediatric Secondary Hemophagocytic Lymphohistiocytosis

Arthritis & Rheumatology, 2020
To assess the benefit of the recombinant human interleukin‐1 receptor antagonist anakinra in treating pediatric patients with secondary hemophagocytic lymphohistiocytosis (HLH)/macrophage activation syndrome (MAS) associated with rheumatic and ...
E. Eloseily, P. Weiser, C. Crayne, H. Haines, M. Mannion, M. Stoll, T. Beukelman, T. Atkinson, R. Cron   +8 more
semanticscholar   +1 more source

Ruxolitinib as adjunctive therapy for secondary hemophagocytic lymphohistiocytosis: A case series

European Journal of Haematology, 2021
Hemophagocytic lymphohistiocytosis (HLH) is a cytokine storm syndrome associated with mortality rates of up to 88%. Standard therapy with high‐dose glucocorticoids and etoposide used in adults is extrapolated from pediatric trials, with significant ...
S. Hansen, W. Alduaij, C. Biggs, S. Belga, K. Luecke, H. Merkeley, Luke Y. C. Chen   +6 more
semanticscholar   +1 more source

Neonatal Hemophagocytic Lymphohistiocytosis

NeoReviews, 2019
Hemophagocytic lymphohistiocytosis (HLH) is extremely rare in the neonatal period. The incidence of neonatal HLH is not confirmed and may range from 1 in 50,000 to 150,000. The incidence varies based on ethnicity, particularly in populations in which consanguinity is common.
Josef, McLean, Roia, Katebian, Eugene, Suh, Kamran, Mirza, Sachin, Amin   +4 more
openaire   +2 more sources

Efficacy of Moderately Dosed Etoposide in Macrophage Activation Syndrome–Hemophagocytic Lymphohistiocytosis

Journal of Rheumatology, 2021
Objective Macrophage activation syndrome (MAS) constitutes 1 subtype of the hyperinflammatory syndrome hemophagocytic lymphohistiocytosis (HLH), and the term MAS-HLH was recently proposed for HLH with underlying autoimmune/autoinflammatory conditions ...
A. Horne, Tatiana von Bahr Greenwood, S. Chiang, Marie Meeths, C. Björklund, M. Ekelund, Peter Erensjö, S. Berg, S. Hagelberg, Y. Bryceson, U. Andersson, J. Henter   +11 more
semanticscholar   +1 more source

Familial Hemophagocytic Lymphohistiocytosis

Hematology/Oncology Clinics of North America, 2015
Familial hemophagocytic lymphohistiocytosis (FHL) is a rare heritable disorder of immune regulation that is typically characterized by sudden onset of severe systemic illness. Functional impairment or absence of 1 or more of several proteins that participate in lymphocyte cytotoxicity underlies the disease. Although FHL usually presents in infancy, age
openaire   +2 more sources

Familial hemophagocytic lymphohistiocytosis

European Journal of Pediatrics, 1983
Familial hemophagocytic lymphohistiocytosis (FHL) is probably a genetically transmitted disease affecting infants and very young children. Cardinal symptoms are fever, hepatosplenomegaly, and pancytopenia. Frequently meningeal involvement is seen, manifested by neurologic symptoms and a lymphohistiocytic pleocytosis with increased protein levels in the
openaire   +2 more sources