Results 1 to 10 of about 13,951 (163)
Hemophagocytic Lymphohistiocytosis [PDF]
Annual Review of Pathology: Mechanisms of Disease, 2018 Hemophagocytic lymphohistiocytosis is a life-threatening disorder characterized by unbridled activation of cytotoxic T lymphocytes, natural killer (NK) cells, and macrophages resulting in hypercytokinemia and immune-mediated injury of multiple organ systems.
Hanny Al-Samkari
exaly +5 more sources
Hemophagocytic Lymphohistiocytosis [PDF]
Archives of Pathology & Laboratory Medicine, 2021 Context.— Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder of immune regulation that can eventually result in end-organ damage and death. HLH is characterized by uncontrolled activation of cytotoxic T lymphocytes, natural killer cells, and macrophages that can lead to a cytokine ...
Tanya Sajan, Ponnatt +2 more
openaire +2 more sources
Hemophagocytic Lymphohistiocytosis
Pediatrics In Review, 2022 Hemophagocytic lymphohistiocytosis (HLH) is an aggressive life-threatening disease that consists of uncontrolled activated lymphocytes and macrophages that secrete excessive cytokines. Symptoms and laboratory findings of HLH include prolonged fever, cytopenia, hepatosplenomegaly, liver dysfunction, hypertriglyceridemia, hyperferritinemia, increased ...
Hannah, Major-Monfried +2 more
openaire +6 more sources
Neurological symptoms of familial hemophagocytic lymphohistiocytosis type 2 [PDF]
Journal of Integrative Neuroscience, 2020 Hemophagocytic lymphohistiocytosis with central nervous system involvement is caused by inflammatory factor storms. The inflammatory factors invade the blood-brain barrier and further infiltrate brain tissue resulting in associated neurological and/or ...
Jingshi Wang, Houzhen Tuo, Lin Wu, Xinkai Wang, Zhao Wang
doaj +1 more source
Orphanet Journal of Rare Diseases, 2021 Hemophagocytic lymphohistiocytosis during pregnancy is rare; it is often misdiagnosed, resulting in a high maternal and foetal mortality rate. Herein, based on limited case reports including antepartum and postpartum cases, we reviewed the current ...
Lidong Liu +4 more
doaj +1 more source
[Hemophagocytic lymphohistiocytosis]. [PDF]
Nihon rinsho. Japanese journal of clinical medicine, 2013 Hemophagocytic lymphohistiocytosis (HLH) is a frequently fatal and likely underdiagnosed disease involving a final common pathway of hypercytokinemia, which can result in end-organ damage and death. Although an early diagnosis is crucial to decrease mortality, the definitive diagnosis is often challenging because of the lack of specificity of currently
Flavia G N, Rosado, Annette S, Kim
openaire +5 more sources
Hemophagocytic Lymphohistiocytosis [PDF]
Indian Journal of Hematology and Blood Transfusion, 2012 Hemophagocytic lymphohistiocytosis (HLH) is an immune disorder characterized by uncontrolled inflammation due to defective immune response. It may be familial or acquired, but both share a common feature of threatening the life of a patient and may lead to death unless treated by appropriate treatment. Here in we report a case of adult HLH.
A M V R, Narendra +5 more
openaire +2 more sources
Critical Care Explorations, 2021 Objectives:. Hemophagocytic lymphohistiocytosis is a life-threatening hyperinflammatory disorder that is associated with high morbidity and mortality in the ICU. It has also been associated with acute liver failure. Design:.
Nawar Al Nasrallah, MD +3 more
doaj +1 more source
Approaching hemophagocytic lymphohistiocytosis
Frontiers in Immunology, 2023 Hemophagocytic Lymphohistiocytosis (HLH) is a rare clinical condition characterized by sustained but ineffective immune system activation, leading to severe and systemic hyperinflammation. It may occur as a genetic or sporadic condition, often triggered by an infection.
Aurora Chinnici +10 more
openaire +4 more sources
Haematologica, 2015 The hyperinflammatory syndrome hemophagocytic lymphohistiocytosis can occur in the context of malignancies. Malignancy-triggered hemophagocytic lymphohistiocytosis should be regarded seperately from hemophagocytic lymphohistiocytosis during ...
Kai Lehmberg +9 more
doaj +1 more source