An analysis of reported cases of hemophagocytic lymphohistiocytosis (HLH) after COVID-19 vaccination
Human Vaccines and Immunotherapeutics, 2023 Although COVID-19 vaccines are an effective public health tool to combat the global pandemic, serious adverse events, such as hemophagocytic lymphohistiocytosis (HLH), caused by them are a concern.
Qing-Tai Cao, Marady Hun, Lin Cao
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CNS Involvement in HLH (CNS-HLH)
, 2017 CNS disease is considered to be a result of the pathologic immune response in HLH. CNS involvement is frequently found at diagnosis or can occur anytime in the further course of systemic HLH but has also been reported as primary or only manifestation.
AnnaCarin Horne, Karin Beutel
openaire +2 more sources
Early imaging differentiation of children with acute hematologic malignancies that present in pancytopenia: a retrospective study [PDF]
Frontiers in OncologyObjectivesThis retrospective cohort study aimed to identify potential differentiation indicators on thoracic and abdominal computed tomography (CT) among three hematologic malignancies characterized by acute pancytopenia in children.MethodsThis study was
Junya Ma +8 more
doaj +2 more sources
Transcriptional Targets of the REF-1 Family Proteins: HLH-25/ HLH-28/HLH-29
, 2011 Notch signaling is important for development in Caenorhabditis elegans and the REF-1 family pro-teins, a set of the bHLH transcription factors, are the first targets of Notch signaling. Little is known about the molecular mechanisms employed by the REF-1 family to regulate development.
Wang, Kun
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Identifying Hemophagocytic Lymphohistiocytosis and Describing Outcomes Using Computable Phenotypes: Retrospective Cohort Study [PDF]
JMIR CancerBackgroundHemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome that requires rapid diagnosis and intervention. However, identifying these patients is difficult because the HLH-2004 diagnostic criteria are complex and ...
Suheyla Ocak +7 more
doaj +2 more sources
Hemophagocytic Lymphohistiocytosis (HLH)
South Eastern European Journal of Public HealthHLH is a reactive process resulting from prolonged and excessive antigen-presenting cell activation [1]. Hemophagocytosis is a hallmark of activated macrophages/histiocytes. The predominant clinical findings of HLH are fever (often hectic and persistent), cytopenia, hepatitis, and splenomegaly. A case of HLH in a 32-year-old female with no past medical
Fadi Mohammad Mobarrak, Farid Ullah Khan
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Adult-onset primary hemophagocytic syndrome with concurrent Epstein–Barr virus infection: a case report with literature review [PDF]
Frontiers in OncologyObjectiveTo investigate the clinical and laboratory features, phenotypic characteristics, associated genes, and treatment strategies for adult primary hemophagocytic lymphohistiocytosis (HLH).MethodsThe clinical characteristics and underlying causes of ...
Lei Huang, Shuli Guo
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Real-world use of emapalumab in hemophagocytic lymphohistiocytosis: a scoping review of published evidence [PDF]
Frontiers in PharmacologyBackgroundEmapalumab, an interferon-γ (interferon-gamma)–blocking monoclonal antibody, has emerged as a targeted therapy for refractory hemophagocytic lymphohistiocytosis (HLH).
Abdulrahman F. Al-Mashdali +7 more
doaj +2 more sources
A Wolf in Sheep's Clothing: Systemic Immune Activation Post Immunotherapy [PDF]
Journal of Immunotherapy and Precision Oncology, 2021 Introduction: Immune checkpoint inhibitors (ICIs) are increasingly a standard of care for many cancers; these agents can result in immune-related adverse events (irAEs) including fever, which is common but can rarely be associated with systemic immune ...
Crescens Tiu +14 more
doaj +1 more source
Sri Lanka Journal of Medicine, 2022 Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder characterized by excessive activation of the immune system leading to tissue damage and organ dysfunction.
U. P. Edirisinghe, J. Indrakumar
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