Results 11 to 20 of about 22,345 (254)

A retrospective analysis of etiology and outcomes of hemophagocytic lymphohistiocytosis in children and adults [PDF]

Yeungnam University Journal of Medicine, 2021
Background Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe, life-threatening inflammatory condition if untreated. We aimed to investigate the etiologies, outcomes, and risk factors for death in children and adults with HLH.
Abraham Kwak, Nani Jung, Ye Jee Shim, Heung Sik Kim, Hyun Ji Lim, Jae Min Lee, Mi Hwa Heo, Young Rok Do   +7 more
doaj   +1 more source

Soluble interleukin-2 receptor in pediatric patients investigated for hemophagocytic lymphohistiocytosis: A single-center, 10-year-long experience [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2023
Introduction/Objective Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory condition characterized by fever, splenomegaly, and cytopenias.
Janković Srđa, Ćazić Marija, Janić Dragana, Lazić Jelena, Rodić Predrag, Krstovski Nada   +5 more
doaj   +1 more source

Patient with Jaundice, Dyspnea and Hyperferritinemia after COVID-19

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2022
The aim: to highlight the importance of considering hemophagocytic lymphohistiocytosis in patients with jaundice of unclear origin and systemic inflammatory manifestations after coronavirus infection.Key points. A 64-y.o.
V. R. Grechishnikova, P. E. Tkachenko, M. S. Zharkova, T. P. Nekrasova, V. T. Ivashkin   +4 more
doaj   +1 more source

Calming the storm in HLH [PDF]

Blood, 2019
In this issue of Blood, Albeituni et al demonstrate the pleiotropic immunomodulatory effects by which the Janus kinase (JAK) inhibitor ruxolitinib ameliorates hypercytokinemia and organ injury in 2 distinct murine models of hemophagocytic lymphohistiocytosis (HLH).1 By demonstrating both interferon-γ (IFN-γ)–dependent and IFN-γ–independent effects, the
Matt S. Zinter, Michelle L. Hermiston
openaire   +2 more sources

Soluble Interleukin-2 Receptor Level as a Marker of Hemophagocytic Lymphohistiocytosis in Children With Severe Dengue

Frontiers in Pediatrics, 2021
Dengue induced-hemophagocytic lymphohistiocytosis (HLH) is increasingly recognized as an important cause of secondary HLH. Early identification of dengue HLH and directed therapy for HLH may help to alter the outcomes in critically ill patients.
Dhirendra Singh, Veena Raghunathan, Maninder Dhaliwal, Neha Rastogi, Ritu Chadha, Satya Prakash Yadav   +5 more
doaj   +1 more source

HLH-26 is expressed in the intestine.

, 2022
(A) hlh-26p::gfp expression in young adult transgenic worms assessed by fluorescence microscopy (25×). coel::rfp was used as the coinjection marker. Survival curves assaying E.
Yu Sang (2551267), Jie Ren (176083), Alejandro Aballay (51596)   +2 more
core   +1 more source

Scrub Typhus Complicated by Acute Respiratory Distress Syndrome and Haemophagocytic Lymphohistiocytosis in a Young Patient [PDF]

Journal of Clinical and Diagnostic Research, 2018
Scrub typhus is an endemic rickettsial disease causing vasculitis involving the small vessels of the body. Haemophagocytic Lymphohistiocytosis (HLH) is a hyperinflammatory syndrome characterised by excessive unbalanced cytokine release.
Shveta, Kiran Agarwal, Bhavika Rishi, Khushboo   +3 more
doaj   +1 more source

HLH-30::GFP dynamics during food deprivation.

, 2022
In this sample video, a maximum intensity projection of one hlh-30::gfp transgenic animal is shown from 45 mins to 225 mins post starvation, sped up to 3 fps. (AVI)
Hiu E. Lau (12505892), Anupama Singh (414518), Malene Hansen (10367), Karina Kono (4164274), Jessica A. Haley (12505895), Molly A. Matty (6432926), Kirthi C. Reddy (12505901), Sreekanth H. Chalasani (3291729), Ahana Chakraborty (12505898)   +8 more
core   +1 more source

Germline HAVCR2 mutations and their relation to the clinical spectrum of subcutaneous panniculitis-like T-cell lymphoma and hemophagocytic lymphohistiocytosis: results from a multicenter study and meta-analysis

Haematologica, 2023
Germline HAVCR2 mutations are frequently detected in subcutaneous panniculitis-like T-cell lymphoma (SPTCL) patients with/without hemophagocytic lymphohistiocytosis (HLH) but factors associated with variable manifestations remain undetermined.
Chatphatai Moonla, Chantana Polprasert, Patcharee Komvilaisak, Thanawat Rattanathammethee, Sunisa Kongkiatkamon, Kitsada Wudhikarn, Sirorat Kobbuaklee, Pitchayut Boonyabaramee, Nuanrat Tangcheewinsirikul, Samart Pakakasama, Piya Rujkijyanont, Chane Choed-Amphai, Kamon Phuakpet, Saranya Pongudom, Udomsak Bunworasate, Narittee Sukswai, Darintr Sosothikul, Ponlapat Rojnuckarin   +17 more
doaj   +1 more source

HLH-26 regulates an innate immune transcriptional program.

, 2022
(A) GO analysis of up-regulated and down-regulated genes in hlh-26(ok1453) animals grown on E. faecium. (B) qRT-PCR validation of selected innate immune genes that were down-regulated in hlh-26(ok1453) mutants (N = 3 biological replicates).
Yu Sang (2551267), Jie Ren (176083), Alejandro Aballay (51596)   +2 more
core   +1 more source