Results 41 to 50 of about 24,724 (214)
Immune checkpoint inhibitor-induced hemophagocytic lymphohistiocytosis in lung cancer: a case series [PDF]
Exploration of Targeted Anti-tumor TherapyImmune checkpoint inhibitors (ICIs) are established treatments for various malignancies, including lung, kidney, and colorectal cancers. However, their broad use has led to an increase in immune-related adverse events (irAEs), with thyroiditis, colitis ...
Abdul Wali Khan +5 more
doaj +1 more source
HLH-1 is required for establishing muscle proteostasis.
, 2016 (A) Q0, Q35, Q0;hlh-1(cc561) or Q35;hlh-1(cc561) embryos laid at 15°C were scored for embryonic arrest. Data are presented as means ± SEM of at least 6 independent experiments.
Yael Bar-Lavan (3608987) +5 more
core +1 more source
ALFA-1/C9orf72 regulates lipid metabolism through HLH-30/TFEB.
, 2020 (A) Representative images of Nile Red staining in N2, alfa-1(ok3062), HLH-30::GFP-expressing wild-type and HLH-30::GFP-expressing alfa-1(ok3062) mutant C. elegans after 1 day of starvation. Enlarged images of boxed areas are shown in each panel.
Yon Ju Ji (3359057) +5 more
core +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Microdeletions impacting 15q11.2 breakpoint (BP) 1 to BP2, adjacent to the Prader–Willi critical region, have previously described neuropsychiatric associations, with potential low penetrance presentations of congenital heart disease (CHD) also identified.
Morgan B. Wright +10 more
wiley +1 more source
, 2019 In wild-type C. elegans under starvation conditions, HLH-30 activates lysosome biogenesis and catabolic pathways, which encourage starvation survival and prime the animal for recovery from starvation upon re-feeding. Without HLH-30, C.
Ben Zhou (197219) +1 more
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective Still disease (SD) is an autoinflammatory disorder characterized by remarkably high interleukin‐18 (IL‐18) levels. Increasing evidence suggests that adaptive immunity also contributes to its pathogenesis, particularly in refractory courses. Macrophage activation syndrome (MAS), one of SD's most severe complications, is associated with further
Greta Rogani +17 more
wiley +1 more source
Cytometry Part B: Clinical Cytometry, EarlyView.Abstract Natural killer (NK) cell neoplasms span indolent to highly aggressive entities, and flow cytometric immunophenotyping is central to their detection and classification. However, distinguishing reactive from neoplastic NK cell expansions can be challenging because NK cells lack somatically recombined antigen receptors, and reactive states may ...
Aaron J. Wilk +7 more
wiley +1 more source
, 2017 Autophagy is an evolutionarily conserved intracellular system that maintains cellular homeostasis by degrading and recycling damaged cellular components.
Horng-Dar Wang (112368) +11 more
core +1 more source
Transcriptional Targets of the REF-1 Family Proteins: HLH-25/ HLH-28/HLH-29 [PDF]
, 2011 Notch signaling is important for development in Caenorhabditis elegans and the REF-1 family pro-teins, a set of the bHLH transcription factors, are the first targets of Notch signaling. Little is known about the molecular mechanisms employed by the REF-1
Wang, Kun
core +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.In this post‐transplant patient, increased hyaline casts with negative dipstick protein but positive SSA testing occurred during evolving acute kidney injury and resolved with renal recovery. This discordant urinalysis pattern may warrant confirmatory protein testing and correlation with serial renal function in patients at high risk of AKI.
Yifei Jia +6 more
wiley +1 more source