Results 131 to 140 of about 69,645 (303)

Estimating the Factor VIII‐Equivalent Activity of Emicizumab Using Global Assays of Haemostasis

open access: yesHaemophilia, EarlyView.
ABSTRACT Background Emicizumab is a bispecific monoclonal antibody mimicking factor (F) VIII activity and an effective therapy for prophylaxis in people with haemophilia A (PWHA). The FVIII‐equivalent activity (FVIIIeq) of emicizumab remains unknown. Objectives To estimate FVIIIeq of emicizumab using global assays of haemostasis.
Daniel Kraemmer   +6 more
wiley   +1 more source

Radiological Stage of Hemophilic Arthropathy of Knee Does Not Correlate With Clinical Variables

open access: yesHaemophilia, EarlyView.
ABSTRACT Background Various functional and radiological systems have been developed to evaluate joint health and the severity of arthropathy in hemophilic patients. Clinical relevance of these radiological systems has received minimal attention. Methods Through a retrospective chart review, 84 patients with end‐stage hemophilic arthropathy of the knee ...
Arman Vahabi   +4 more
wiley   +1 more source

Spinal Stenosis: An Emerging Complication of Ageing in People With Haemophilia

open access: yesHaemophilia, EarlyView.
ABSTRACT Introduction Advances in haemophilia care have brought the challenges of ageing for people with haemophilia (PWH) to the forefront. Age‐related spinal degeneration may result in spinal stenosis; however, the rates in PWH are unknown. We sought to systematically review Irish PWH to address this gap in the current literature.
Claire Kelly   +19 more
wiley   +1 more source

Qualification Criteria of Gene Therapy for Haemophilia—Opinion of the EAHAD Gene Therapy Working Group

open access: yesHaemophilia, EarlyView.
Abstract Background Following the approval of the first gene therapies for haemophilia, it is essential to develop an optimal infrastructure for the administration of gene therapy. This can be ensured by identifying the criteria for the definition of treatment centres (hub centres) and follow‐up centres (spoke centres), as well as establishing ...
Wolfgang Miesbach   +8 more
wiley   +1 more source

Managing Haemophilic Arthropathy in People With Haemophilia in Japan: An Informal Consensus

open access: yesHaemophilia, EarlyView.
ABSTRACT Introduction People with haemophilia who develop haemophilic arthropathy experience disabling physical effects, limiting functionality and quality of life (QOL). Although Clinical Practice Guidelines are available for haemophilia management, consensus on haemophilic arthropathy management is needed.
Kumiko Ono   +13 more
wiley   +1 more source

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