Results 91 to 100 of about 48,361 (234)
ABSTRACT Background Bone diseases, such as low bone mineral density and osteoporosis is an emerging concern in people with haemophilia (PWH). As a consequence, PWH might experience fractures more frequently than the general population. Our primary aim was to compare the incidence of bone fractures in PWH and controls without bleeding disorders.
Federico Germini +6 more
wiley +1 more source
Background Hemophilia patients are prone to spontaneous or post-traumatic bleeding, particularly in joints and various other body sites. The high incidence of joint hemorrhages in hemophilia patients underscores the importance of routine joint ...
Sujan Ghosh +6 more
doaj +1 more source
Hemophilia is associated with accelerated biological aging
Hemophilia is a rare X-linked bleeding disorder caused by mutations in the F8 or F9 gene (hemophilia A or B), leading to deficient factor VIII or IX proteins, respectively.
Marina Trappl +7 more
doaj +1 more source
Guidelines for management of hemophilia A and B [letter; comment] [PDF]
Benjamin Djulbegović, G. Goldsmith
openalex +1 more source
Transduction of modified factor VIII gene improves lentiviral gene therapy efficacy for hemophilia A [PDF]
Jie Gong +4 more
openalex +1 more source
ABSTRACT Background Glanzmann thrombasthenia (GT) is an inherited platelet disorder resulting in severely reduced platelet aggregation and increased bleeding tendency. Pregnancy and childbirth in women with GT present significant challenges for both mother and child.
Karlijn H. G. Rutten +11 more
wiley +1 more source
In vivo characterization of recombinant factor VIII in a canine model of hemophilia A (factor VIII deficiency) [PDF]
AR Giles +5 more
openalex +1 more source
Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates [PDF]
Michela Milani +16 more
openalex +1 more source
ABSTRACT Background The clinical focus of haemophilia has expanded beyond bleeding outcomes to encompass long‐term comorbidities such as cardiovascular disease (CVD). However, it remains unclear when vascular changes begin in this population. Carotid intima‐media thickness (cIMT), a validated, non‐invasive marker of subclinical atherosclerosis, may ...
Alyson Trillo +5 more
wiley +1 more source

